International Journal of Cancer Management

Published by: Kowsar

Endoscopic and Colonoscopic Findings in Patients with Iron Deficiency Anemia: The Risk of Cancer

Ali Shahriari-Ahmadi 1 , Neda Shalbaf 2 , Mohsen Masoodi 3 , Maryam Shalbaf 4 , Vida Bozorgi 2 and Masoud Sadeghi 5 , *
Authors Information
1 Department of Hematology and Medical Oncology, Rasoul-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
2 Department of Internal Medicine, Rasoul-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
3 Colorectal Research Center, Rasoul-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
4 Shooshtar Branch, Azad University of Shooshtar, Iran
5 Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
Article information
  • International Journal of Cancer Management: October 2017, 10 (10); e8222
  • Published Online: October 31, 2017
  • Article Type: Research Article
  • Received: September 30, 2016
  • Revised: December 3, 2016
  • Accepted: December 26, 2016
  • DOI: 10.5812/ijcm.8222

To Cite: Shahriari-Ahmadi A, Shalbaf N, Masoodi M, Shalbaf M, Bozorgi V, et al. Endoscopic and Colonoscopic Findings in Patients with Iron Deficiency Anemia: The Risk of Cancer, Int J Cancer Manag. 2017 ; 10(10):e8222. doi: 10.5812/ijcm.8222.

Copyright © 2017, Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Methods
3. Results
4. Discussion
  • 1. Umbreit J. Iron deficiency: a concise review. Am J Hematol. 2005;78(3):225-31. doi: 10.1002/ajh.20249. [PubMed: 15726599].
  • 2. Knight K, Wade S, Balducci L. Prevalence and outcomes of anemia in cancer: a systematic review of the literature. Am J Med. 2004;116 Suppl 7A:11S-26S. doi: 10.1016/j.amjmed.2003.12.008. [PubMed: 15050883].
  • 3. Hung N, Shen CC, Hu YW, Hu LY, Yeh CM, Teng CJ, et al. Risk of cancer in patients with iron deficiency anemia: a nationwide population-based study. PLoS One. 2015;10(3). e0119647. doi: 10.1371/journal.pone.0119647. [PubMed: 25781632].
  • 4. Jolobe O. Guidelines for the management of iron deficiency anaemia. Gut. 2001;49(1):158. doi: 10.1136/gut.49.1.158. [PubMed: 11444240].
  • 5. Ho CH, Yu YB, Wu PH. The prevalence of iron deficiency anemia and its clinical implications in patients with colorectal carcinoma. J Chin Med Assoc. 2008;71(3):119-22. doi: 10.1016/S1726-4901(08)70002-9. [PubMed: 18364262].
  • 6. Peek RJ, Blaser MJ. Helicobacter pylori and gastrointestinal tract adenocarcinomas. Nat Rev Cancer. 2002;2(1):28-37. doi: 10.1038/nrc703. [PubMed: 11902583].
  • 7. Hansen S, Melby KK, Aase S, Jellum E, Vollset SE. Helicobacter pylori infection and risk of cardia cancer and non-cardia gastric cancer. A nested case-control study. Scand J Gastroenterol. 1999;34(4):353-60. doi: 10.1080/003655299750026353. [PubMed: 10365894].
  • 8. Powell N, McNair A. Gastrointestinal evaluation of anaemic patients without evidence of iron deficiency. Eur J Gastroenterol Hepatol. 2008;20(11):1094-100. doi: 10.1097/MEG.0b013e328304d621. [PubMed: 19047841].
  • 9. James MW, Chen CM, Goddard WP, Scott BB, Goddard AF. Risk factors for gastrointestinal malignancy in patients with iron-deficiency anaemia. Eur J Gastroenterol Hepatol. 2005;17(11):1197-203. [PubMed: 16215432].
  • 10. Muhammad A, Pitchumoni CS. Evaluation of iron deficiency anemia in older adults: the role of wireless capsule endoscopy. J Clin Gastroenterol. 2009;43(7):627-31. doi: 10.1097/MCG.0b013e318181b442. [PubMed: 19623687].
  • 11. Rockey DC. Gastrointestinal tract evaluation in patients with iron deficiency anemia. Semin Gastrointest Dis. 1999;10(2):53-64. [PubMed: 10361896].
  • 12. Kepczyk T, Kadakia SC. Prospective evaluation of gastrointestinal tract in patients with iron-deficiency anemia. Dig Dis Sci. 1995;40(6):1283-9. doi: 10.1007/BF02065539. [PubMed: 7781448].
  • 13. Raje D, Mukhtar H, Oshowo A, Ingham Clark C. What proportion of patients referred to secondary care with iron deficiency anemia have colon cancer?. Dis Colon Rectum. 2007;50(8):1211-4. doi: 10.1007/s10350-007-0249-y. [PubMed: 17587088].
  • 14. Annibale B, Capurso G, Chistolini A, D'Ambra G, DiGiulio E, Monarca B, et al. Gastrointestinal causes of refractory iron deficiency anemia in patients without gastrointestinal symptoms. Am J Med. 2001;111(6):439-45. doi: 10.1016/S0002-9343(01)00883-X. [PubMed: 11690568].
  • 15. Acher PL, Al-Mishlab T, Rahman M, Bates T. Iron-deficiency anaemia and delay in the diagnosis of colorectal cancer. Colorectal Dis. 2003;5(2):145-8. doi: 10.1046/j.1463-1318.2003.00415.x. [PubMed: 12780903].
  • 16. Beale AL, Penney MD, Allison MC. The prevalence of iron deficiency among patients presenting with colorectal cancer. Colorectal Dis. 2005;7(4):398-402. doi: 10.1111/j.1463-1318.2005.00789.x. [PubMed: 15932566].
  • 17. Ullman TA, Itzkowitz SH. Intestinal inflammation and cancer. Gastroenterology. 2011;140(6):1807-16. doi: 10.1053/j.gastro.2011.01.057. [PubMed: 21530747].
  • 18. Nagy TA, Frey MR, Yan F, Israel DA, Polk DB, Peek RJ. Helicobacter pylori regulates cellular migration and apoptosis by activation of phosphatidylinositol 3-kinase signaling. J Infect Dis. 2009;199(5):641-51. doi: 10.1086/596660. [PubMed: 19199544].
  • 19. Wroblewski LE, Peek RJ, Wilson KT. Helicobacter pylori and gastric cancer: factors that modulate disease risk. Clin Microbiol Rev. 2010;23(4):713-39. doi: 10.1128/CMR.00011-10. [PubMed: 20930071].
  • 20. Najafi F, Mozaffari HR, Karami M, Izadi B, Tavvafzadeh R, Pasdar Y. Trends in incidence of gastrointestinal tract cancers in Western iran, 1993-2007. Iran Red Crescent Med J. 2011;13(11):805-10. [PubMed: 22737419].
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments