International Journal of Cancer Management

Published by: Kowsar

A New Mutation in WT1 Gene Associated with Wilms Tumor with Reduced Penetrance in an Iranian Family

Majid Fardaei 1 , Seyed Mohammad Bagher Tabei 1 , Soudeh Ghafouri-Fard 2 , * and Mohammad Miryounesi 3 , **
Authors Information
1 Department of Medical Genetics, Shiraz University of Medical sciences, Shiraz, IR Iran
2 Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
3 Genomic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
Corresponding Authors:
Article information
  • International Journal of Cancer Management: August 2017, 10 (8); e7500
  • Published Online: August 31, 2017
  • Article Type: Letter
  • Received: July 11, 2016
  • Revised: July 16, 2016
  • Accepted: July 25, 2017
  • DOI: 10.5812/ijcm.7500

To Cite: Fardaei M, Bagher Tabei S M, Ghafouri-Fard S, Miryounesi M. A New Mutation in WT1 Gene Associated with Wilms Tumor with Reduced Penetrance in an Iranian Family, Int J Cancer Manag. 2017 ; 10(8):e7500. doi: 10.5812/ijcm.7500.

Copyright © 2017, International Journal of Cancer Management. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
Acknowledgements
Footnotes
References
  • 1. Kaneko Y, Okita H, Haruta M, Arai Y, Oue T, Tanaka Y, et al. A high incidence of WT1 abnormality in bilateral Wilms tumours in Japan, and the penetrance rates in children with WT1 germline mutation. Br J Cancer. 2015; 112(6): 1121-33[DOI][PubMed]
  • 2. Jeanpierre C, Denamur E, Henry I, Cabanis MO, Luce S, Cecille A, et al. Identification of constitutional WT1 mutations, in patients with isolated diffuse mesangial sclerosis, and analysis of genotype/phenotype correlations by use of a computerized mutation database. Am J Hum Genet. 1998; 62(4): 824-33[DOI][PubMed]
  • 3. Haruta M, Arai Y, Watanabe N, Fujiwara Y, Honda S, Ohshima J, et al. Different incidences of epigenetic but not genetic abnormalities between Wilms tumors in Japanese and Caucasian children. Cancer Sci. 2012; 103(6): 1129-35[DOI][PubMed]
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  • 6. Toogeh G, Ramzi M, Faranoush M, Amirizadeh N, Haghpanah S, Moghadam M, et al. Prevalence and Prognostic Impact of Wilms' Tumor 1 (WT1) Gene, Including SNP rs16754 in Cytogenetically Normal Acute Myeloblastic Leukemia (CN-AML): An Iranian Experience. Clin Lymphoma Myeloma Leuk. 2016; 16(3)-6[DOI][PubMed]
  • 7. Jeanpierre C, Beroud C, Niaudet P, Junien C. Software and database for the analysis of mutations in the human WT1 gene. Nucleic Acids Res. 1998; 26(1): 271-4[PubMed]
  • 8. Royer-Pokora B, Weirich A, Schumacher V, Uschkereit C, Beier M, Leuschner I, et al. Clinical relevance of mutations in the Wilms tumor suppressor 1 gene WT1 and the cadherin-associated protein beta1 gene CTNNB1 for patients with Wilms tumors: results of long-term surveillance of 71 patients from International Society of Pediatric Oncology Study 9/Society for Pediatric Oncology. Cancer. 2008; 113(5): 1080-9[DOI][PubMed]
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