International Journal of Cancer Management

Published by: Kowsar

The Relationship of Reproductive Risk Factors and Histologic Patterns with Molecular Subtypes of Breast Cancer

Fataneh Zeiyaie 1 , Nahid Nafissi 2 , Maryam Khayamzadeh 1 , Atieh Akbari ORCID 1 and Mohammad Esmaeil Akbari ORCID 1 , *
Authors Information
1 Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2 Department of Surgery, Iran University of Medical Sciences, Tehran, Iran
Article information
  • International Journal of Cancer Management: June 2018, 11 (6); e66746
  • Published Online: June 9, 2018
  • Article Type: Research Article
  • Received: February 12, 2018
  • Revised: March 18, 2018
  • Accepted: April 8, 2018
  • DOI: 10.5812/ijcm.66746

How to Cite: Zeiyaie F, Nafissi N, Khayamzadeh M, Akbari A, Akbari M E. The Relationship of Reproductive Risk Factors and Histologic Patterns with Molecular Subtypes of Breast Cancer, Int J Cancer Manag. 2018 ; 11(6):e66746. doi: 10.5812/ijcm.66746.

Copyright © 2018, Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Methods
3. Results
4. Discussion
  • 1. Li H, Sun X, Miller E, Wang Q, Tao P, Liu L, et al. BMI, reproductive factors, and breast cancer molecular subtypes: A case-control study and meta-analysis. J Epidemiol. 2017;27(4):143-51. doi: 10.1016/ [PubMed: 28142040]. [PubMed Central: PMC5376312].
  • 2. Molnar IA, Molnar BA, Vizkeleti L, Fekete K, Tamas J, Deak P, et al. Breast carcinoma subtypes show different patterns of metastatic behavior. Virchows Arch. 2017;470(3):275-83. doi: 10.1007/s00428-017-2065-7. [PubMed: 28101678].
  • 3. Holm J, Eriksson L, Ploner A, Eriksson M, Rantalainen M, Li J, et al. Assessment of Breast Cancer Risk Factors Reveals Subtype Heterogeneity. Cancer Res. 2017;77(13):3708-17. doi: 10.1158/0008-5472.CAN-16-2574. [PubMed: 28512241].
  • 4. Yang XR, Sherman ME, Rimm DL, Lissowska J, Brinton LA, Peplonska B, et al. Differences in risk factors for breast cancer molecular subtypes in a population-based study. Cancer Epidemiol Biomarkers Prev. 2007;16(3):439-43. doi: 10.1158/1055-9965.EPI-06-0806. [PubMed: 17372238].
  • 5. Sartor H, Zackrisson S, Elebro K, Hartman L, Borgquist S. Mammographic density in relation to tumor biomarkers, molecular subtypes, and mode of detection in breast cancer. Cancer Causes Control. 2015;26(6):931-9. doi: 10.1007/s10552-015-0576-6. [PubMed: 25860114].
  • 6. Eriksson L, Hall P, Czene K, Dos Santos Silva I, McCormack V, Bergh J, et al. Mammographic density and molecular subtypes of breast cancer. Br J Cancer. 2012;107(1):18-23. doi: 10.1038/bjc.2012.234. [PubMed: 22644308]. [PubMed Central: PMC3389424].
  • 7. Turkoz FP, Solak M, Petekkaya I, Keskin O, Kertmen N, Sarici F, et al. Association between common risk factors and molecular subtypes in breast cancer patients. Breast. 2013;22(3):344-50. doi: 10.1016/j.breast.2012.08.005. [PubMed: 22981738].
  • 8. Dogan L, Kalaylioglu Z, Karaman N, Ozaslan C, Atalay C, Altinok M. Relationships between epidemiological features and tumor characteristics of breast cancer. Asian Pac J Cancer Prev. 2011;12(12):3375-80. [PubMed: 22471484].
  • 9. Chen FY, Ou HY, Wang SM, Wu YH, Yan GJ, Tang LL. Associations between body mass index and molecular subtypes as well as other clinical characteristics of breast cancer in Chinese women. Ther Clin Risk Manag. 2013;9:131-7. doi: 10.2147/TCRM.S41203. [PubMed: 23576872]. [PubMed Central: PMC3617914].
  • 10. Tamimi RM, Colditz GA, Hazra A, Baer HJ, Hankinson SE, Rosner B, et al. Traditional breast cancer risk factors in relation to molecular subtypes of breast cancer. Breast Cancer Res Treat. 2012;131(1):159-67. doi: 10.1007/s10549-011-1702-0. [PubMed: 21830014]. [PubMed Central: PMC3237947].
  • 11. Lambe M, Hsieh CC, Chan HW, Ekbom A, Trichopoulos D, Adami HO. Parity, age at first and last birth, and risk of breast cancer: a population-based study in Sweden. Breast Cancer Res Treat. 1996;38(3):305-11. doi: 10.1007/BF01806150. [PubMed: 8739084].
  • 12. Kobayashi S, Sugiura H, Ando Y, Shiraki N, Yanagi T, Yamashita H, et al. Reproductive history and breast cancer risk. Breast Cancer. 2012;19(4):302-8. doi: 10.1007/s12282-012-0384-8. [PubMed: 22711317]. [PubMed Central: PMC3479376].
  • 13. Phipps AI, Buist DS, Malone KE, Barlow WE, Porter PL, Kerlikowske K, et al. Reproductive history and risk of three breast cancer subtypes defined by three biomarkers. Cancer Causes Control. 2011;22(3):399-405. doi: 10.1007/s10552-010-9709-0. [PubMed: 21184265]. [PubMed Central: PMC3042513].
  • 14. Althuis MD, Fergenbaum JH, Garcia-Closas M, Brinton LA, Madigan MP, Sherman ME. Etiology of hormone receptor-defined breast cancer: a systematic review of the literature. Cancer Epidemiol Biomarkers Prev. 2004;13(10):1558-68. [PubMed: 15466970].
  • 15. Narod SA. Tumour size predicts long-term survival among women with lymph node-positive breast cancer. Curr Oncol. 2012;19(5):249-53. doi: 10.3747/co.19.1043. [PubMed: 23144572]. [PubMed Central: PMC3457875].
  • 16. Qiu J, Xue X, Hu C, Xu H, Kou D, Li R, et al. Comparison of Clinicopathological Features and Prognosis in Triple-Negative and Non-Triple Negative Breast Cancer. J Cancer. 2016;7(2):167-73. doi: 10.7150/jca.10944. [PubMed: 26819640]. [PubMed Central: PMC4716849].
  • 17. Ma JG, Wang NJ, Yu WJ. [Comparison of biological behavior between triple-negative breast cancer and non-triple- negative breast cancer]. Nan Fang Yi Ke Da Xue Xue Bao. 2011;31(10):1729-32. [PubMed: 22027778].
  • 18. Bediaga NG, Beristain E, Calvo B, Viguri MA, Gutierrez-Corres B, Rezola R, et al. Luminal B breast cancer subtype displays a dicotomic epigenetic pattern. Springerplus. 2016;5:623. doi: 10.1186/s40064-016-2235-0. [PubMed: 27330889]. [PubMed Central: PMC4870487].
  • 19. Serrano-Gomez SJ, Sanabria-Salas MC, Hernandez-Suarez G, Garcia O, Silva C, Romero A, et al. High prevalence of luminal B breast cancer intrinsic subtype in Colombian women. Carcinogenesis. 2016;37(7):669-76. doi: 10.1093/carcin/bgw043. [PubMed: 27207651]. [PubMed Central: PMC4936382].
  • 20. Cherbal F, Gaceb H, Mehemmai C, Saiah I, Bakour R, Rouis AO, et al. Distribution of molecular breast cancer subtypes among Algerian women and correlation with clinical and tumor characteristics: a population-based study. Breast Dis. 2015;35(2):95-102. doi: 10.3233/BD-150398. [PubMed: 25736840].
  • 21. Doebar SC, van den Broek EC, Koppert LB, Jager A, Baaijens MH, Obdeijn IM, et al. Extent of ductal carcinoma in situ according to breast cancer subtypes: a population-based cohort study. Breast Cancer Res Treat. 2016;158(1):179-87. doi: 10.1007/s10549-016-3862-4. [PubMed: 27318854]. [PubMed Central: PMC4937080].
  • 22. Perez AA, Rocha RM, Balabram D, Souza Ada S, Gobbi H. Immunohistochemical profile of high-grade ductal carcinoma in situ of the breast. Clinics (Sao Paulo). 2013;68(5):674-8. doi: 10.6061/clinics/2013(05)15. [PubMed: 23778408]. [PubMed Central: PMC3654337].
  • 23. Poorolajal J, Nafissi N, Akbari ME, Mahjub H, Esmailnasab N, Babaee E. Breast Cancer Survival Analysis Based on Immunohistochemistry Subtypes (ER/PR/HER2): a Retrospective Cohort Study. Arch Iran Med. 2016;19(10):680-6. [PubMed: 27743431].
  • 24. Soerjomataram I, Louwman MW, Ribot JG, Roukema JA, Coebergh JW. An overview of prognostic factors for long-term survivors of breast cancer. Breast Cancer Res Treat. 2008;107(3):309-30. doi: 10.1007/s10549-007-9556-1. [PubMed: 17377838]. [PubMed Central: PMC2217620].
  • 25. Anders CK, Johnson R, Litton J, Phillips M, Bleyer A. Breast cancer before age 40 years. Semin Oncol. 2009;36(3):237-49. doi: 10.1053/j.seminoncol.2009.03.001. [PubMed: 19460581]. [PubMed Central: PMC2894028].
  • 26. Akbari ME, Akbari A, Nafissi N, Shormeij Z, Sayad S, Rohani Rasaf M, et al. Prognostic factors of recurrence (early and late) and death in breast cancer patients in Iranian women. Iran J Cancer Prev. 2016;9(6). doi: 10.17795/ijcp-5747.
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