International Journal of Cancer Management

Published by: Kowsar

First Experience of Intraoperative Radiation Therapy in Cerebral High Grade Glioma in Iran: A Report of Three Cases and Literature Review

Afsoun Seddighi 1 , Mohammad Esmaeil Akbari 2 , Amir Saied Seddighi 1 , * , Afshin Rakhsha 3 , Marjan Vaezi 1 and Amir Hossein Zohrevand 1
Authors Information
1 Functional Neurosurgery Research Center, Shohada Tajrish Neurosurgical Center of Excellence, Shohada Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
2 Cancer Research Centre (CRC), Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
3 Shohada Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
Article information
  • Iranian Journal of Cancer Prevention: October 28, 2015, 8 (5); e3795
  • Published Online: October 27, 2015
  • Article Type: Case Report
  • Received: August 25, 2015
  • Accepted: September 29, 2015
  • DOI: 10.17795/ijcp-3795

To Cite: Seddighi A, Esmaeil Akbari M, Seddighi A S, Rakhsha A, Vaezi M, et al. First Experience of Intraoperative Radiation Therapy in Cerebral High Grade Glioma in Iran: A Report of Three Cases and Literature Review, Int J Cancer Manag. 2015 ; 8(5):e3795. doi: 10.17795/ijcp-3795.

Copyright © 2015, Iranian Journal of Cancer Prevention.This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Introduction
2. Case Presentation
3. Discussion
  • 1. Stupp R, Hegi ME, Mason WP, van den Bent MJ, Taphoorn MJB, Janzer RC, et al. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol. 2009; 10(5): 459-66[DOI]
  • 2. Nuno M, Birch K, Mukherjee D, Sarmiento JM, Black KL, Patil CG. Survival and prognostic factors of anaplastic gliomas. Neurosurgery. 2013; 73(3): 458-65[DOI][PubMed]
  • 3. Heesters M, Molenaar W, Go GK. Radiotherapy in supratentorial gliomas. A study of 821 cases. Strahlenther Onkol. 2003; 179(9): 606-14[DOI][PubMed]
  • 4. Laws ER, Parney IF, Huang W, Anderson F, Morris AM, Asher A, et al. Survival following surgery and prognostic factors for recently diagnosed malignant glioma: data from the Glioma Outcomes Project. J Neurosurg. 2003; 99(3): 467-73[DOI][PubMed]
  • 5. Choucair AK, Levin VA, Gutin PH, Davis RL, Silver P, Edwards MS, et al. Development of multiple lesions during radiation therapy and chemotherapy in patients with gliomas. J Neurosurg. 1986; 65(5): 654-8[DOI][PubMed]
  • 6. Hochberg FH, Pruitt A. Assumptions in the radiotherapy of glioblastoma. Neurology. 1980; 30(9): 907-11[PubMed]
  • 7. Wallner KE, Galicich JH, Krol G, Arbit E, Malkin MG. Patterns of failure following treatment for glioblastoma multiforme and anaplastic astrocytoma. Int J Radiat Oncol Biol Phys. 1989; 16(6): 1405-9[PubMed]
  • 8. Salazar OM, Rubin P, Feldstein ML, Pizzutiello R. High dose radiation therapy in the treatment of malignant gliomas: final report. Int J Radiat Oncol Biol Phys. 1979; 5(10): 1733-40[PubMed]
  • 9. Goldson AL, Streeter OJ, Ashayeri E, Collier-Manning J, Barber JB, Fan KJ. Intraoperative radiotherapy for intracranial malignancies. A pilot study. Cancer. 1984; 54(11 Suppl): 2807-13[PubMed]
  • 10. Abe M, Fukuda M, Yamano K, Matsuda S, Handa H. Intra-operative irradiation in abdominal and cerebral tumours. Acta Radiol Ther Phys Biol. 1971; 10(4): 408-16[PubMed]
  • 11. Sakai N, Yamada H, Andoh T, Hirata T, Nishimura Y, Miwa Y, et al. Intraoperative radiation therapy for malignant glioma. Neurol Med Chir (Tokyo). 1991; 31(11): 702-7[PubMed]
  • 12. Matsutani M, Nakamura O, Nagashima T, Asai A, Fujimaki T, Tanaka H, et al. Intra-operative radiation therapy for malignant brain tumors: rationale, method, and treatment results of cerebral glioblastomas. Acta Neurochir (Wien). 1994; 131(1-2): 80-90[PubMed]
  • 13. Nakamura O, Matsutani M, Shitara N, Okamoto K, Kaneko M, Nakamura H, et al. New treatment protocol by intra-operative radiation therapy for metastatic brain tumours. Acta Neurochir (Wien). 1994; 131(1-2): 91-6[PubMed]
  • 14. Nemoto K, Ogawa Y, Matsushita H, Takeda K, Takai Y, Yamada S, et al. Intraoperative radiation therapy (IORT) for previously untreated malignant gliomas. BMC Cancer. 2002; 2: 1[PubMed]
  • 15. Ortiz de Urbina D, Santos M, Garcia-Berrocal I, Bustos JC, Samblas J, Gutierrez-Diaz JA, et al. Intraoperative radiation therapy in malignant glioma: early clinical results. Neurol Res. 1995; 17(4): 289-94[PubMed]
  • 16. Fujiwara T, Honma Y, Ogawa T, Irie K, Kuyama H, Nagao S, et al. Intraoperative radiotherapy for gliomas. J Neurooncol. 1995; 23(1): 81-6[PubMed]
  • 17. Chung YG, Kim CY, Lee HK, Lee KC, Chu JW, Choi MS. Preliminary experiences with intraoperative radiation therapy (IORT) for the treatment of brain tumors. J Korean Med Sci. 1995; 10(6): 449-52[PubMed]
  • 18. Schueller P, Micke O, Palkovic S, Schroeder J, Moustakis C, Bruns F, et al. 12 years' experience with intraoperative radiotherapy (IORT) of malignant gliomas. Strahlenther Onkol. 2005; 181(8): 500-6[DOI][PubMed]
  • 19. Pichlmeier U, Bink A, Schackert G, Stummer WALA. Glioma Study Group . . Resection and survival in glioblastoma multiforme: an RTOG recursive partitioning analysis of ALA study patients. Neuro Oncol. 2008; 10(6): 1025-34[DOI][PubMed]
  • 20. Zamzuri I, Rahman GI, Muzaimi M, Jafri AM, Nik Ruzman NI, Lutfi YA, et al. Polymodal therapy for high grade gliomas: a case report of favourable outcomes following intraoperative radiation therapy. Med J Malaysia. 2012; 67(1): 121-2[PubMed]
  • 21. Han X, Fu B, Wu M, Zhang H, Li D, Zhang J, et al. P13.13 * Intraoperative Radiotherapy with Intrabeam in Primary Brain Tumors after Resection: Preliminary Reports of 26 Cases. Neuro-Oncology. 2014; 16[DOI]
  • 22. Giordano FA, Brehmer S, Abo-Madyan Y, Welzel G, Sperk E, Keller A, et al. INTRAGO: intraoperative radiotherapy in glioblastoma multiforme-a Phase I/II dose escalation study. BMC cancer. 2014; 14(1): 992
  • 23. Stummer W, Novotny A, Stepp H, Goetz C, Bise K, Reulen HJ. Fluorescence-guided resection of glioblastoma multiforme by using 5-aminolevulinic acid-induced porphyrins: a prospective study in 52 consecutive patients. J Neurosurg. 2000; 93(6): 1003-13[DOI][PubMed]
  • 24. Lacroix M, Abi-Said D, Fourney DR, Gokaslan ZL, Shi W, DeMonte F, et al. A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival. J Neurosurg. 2001; 95(2): 190-8[DOI][PubMed]
  • 25. Curry WJ, Cosgrove GR, Hochberg FH, Loeffler J, Zervas NT. Stereotactic interstitial radiosurgery for cerebral metastases. J Neurosurg. 2005; 103(4): 630-5[DOI][PubMed]
  • 26. Kalapurakal JA, Goldman S, Stellpflug W, Curran J, Sathiaseelan V, Marymont MH, et al. Phase I study of intraoperative radiotherapy with photon radiosurgery system in children with recurrent brain tumors: preliminary report of first dose level (10 Gy). Int J Radiat Oncol Biol Phys. 2006; 65(3): 800-8[DOI][PubMed]
  • 27. Mulhern RK, Palmer SL. Neurocognitive late effects in pediatric cancer. Curr Probl Cancer. 2003; 27(4): 177-97[PubMed]
  • 28. Briere ME, Scott JG, McNall-Knapp RY, Adams RL. Cognitive outcome in pediatric brain tumor survivors: delayed attention deficit at long-term follow-up. Pediatr Blood Cancer. 2008; 50(2): 337-40[DOI][PubMed]
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