International Journal of Cancer Management

Published by: Kowsar

The Effect of Aerobic Exercise in Ambient Particulate Matter on Lung Tissue Inflammation and Lung Cancer

Mohamad Fashi 1 , Hamid Agha Alinejad 1 , * and Hasan Asilian Mahabadi 2
Authors Information
1 Department of Physical Education and Sports Sciences, Tarbiat Modares University, Tehran, IR Iran
2 Deptartment of Occupational Health Engineering, Tarbiat Modares University, Tehran, IR Iran
Article information
  • Iranian Journal of Cancer Prevention: May 28, 2015, 8 (3); e2333
  • Published Online: May 22, 2015
  • Article Type: Research Article
  • Received: January 14, 2015
  • Revised: January 20, 2015
  • Accepted: January 28, 2015
  • DOI: 10.17795/ijcp2333

To Cite: Fashi M, Agha Alinejad H, Asilian Mahabadi H. The Effect of Aerobic Exercise in Ambient Particulate Matter on Lung Tissue Inflammation and Lung Cancer, Int J Cancer Manag. 2015 ; 8(3):e2333. doi: 10.17795/ijcp2333.

Abstract
Copyright © 2015, Iranian Journal of Cancer Prevention.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
Acknowledgements
Footnotes
References
  • 1. Gauderman WJ, Avol E, Gilliland F, Vora H, Thomas D, Berhane K, et al. The effect of air pollution on lung development from 10 to 18 years of age. N Engl J Med. 2004; 351(11): 1057-67[DOI][PubMed]
  • 2. Brunekreef B, Beelen R, Hoek G, Schouten L, Bausch-Goldbohm S, Fischer P, et al. Effects of long-term exposure to traffic-related air pollution on respiratory and cardiovascular mortality in the Netherlands: the NLCS-AIR study. Res Rep Health Eff Inst. 2009; (139): 5-71[PubMed]
  • 3. Knol AB, de Hartog JJ, Boogaard H, Slottje P, van der Sluijs JP, Lebret E, et al. Expert elicitation on ultrafine particles: likelihood of health effects and causal pathways. Part Fibre Toxicol. 2009; 6: 19[DOI][PubMed]
  • 4. Ballaz S, Mulshine JL. The potential contributions of chronic inflammation to lung carcinogenesis. Clin Lung Cancer. 2003; 5(1): 46-62[DOI][PubMed]
  • 5. Yang P, Bamlet WR, Sun Z, Ebbert JO, Aubry MC, Krowka MJ, et al. Alpha1-antitrypsin and neutrophil elastase imbalance and lung cancer risk. Chest. 2005; 128(1): 445-52[DOI][PubMed]
  • 6. Daniels CE, Jett JR. Does interstitial lung disease predispose to lung cancer? Curr Opin Pulm Med. 2005; 11(5): 431-7[PubMed]
  • 7. Santillan AA, Camargo CJ, Colditz GA. A meta-analysis of asthma and risk of lung cancer (United States). Cancer Causes Control. 2003; 14(4): 327-34[PubMed]
  • 8. Gupta SC, Kim JH, Kannappan R, Reuter S, Dougherty PM, Aggarwal BB. Role of nuclear factor kappaB-mediated inflammatory pathways in cancer-related symptoms and their regulation by nutritional agents. Exp Biol Med (Maywood). 2011; 236(6): 658-71[DOI][PubMed]
  • 9. Zienolddiny S, Ryberg D, Maggini V, Skaug V, Canzian F, Haugen A. Polymorphisms of the interleukin-1 beta gene are associated with increased risk of non-small cell lung cancer. Int J Cancer. 2004; 109(3): 353-6[DOI][PubMed]
  • 10. Campa D, Hung RJ, Mates D, Zaridze D, Szeszenia-Dabrowska N, Rudnai P, et al. Lack of association between polymorphisms in inflammatory genes and lung cancer risk. Cancer Epidemiol Biomarkers Prev. 2005; 14(2): 538-9[DOI][PubMed]
  • 11. Lee KM, Shen M, Chapman RS, Yeager M, Welch R, He X, et al. Polymorphisms in immunoregulatory genes, smoky coal exposure and lung cancer risk in Xuan Wei, China. Carcinogenesis. 2007; 28(7): 1437-41[DOI][PubMed]
  • 12. Lind H, Zienolddiny S, Ryberg D, Skaug V, Phillips DH, Haugen A. Interleukin 1 receptor antagonist gene polymorphism and risk of lung cancer: a possible interaction with polymorphisms in the interleukin 1 beta gene. Lung Cancer. 2005; 50(3): 285-90[DOI][PubMed]
  • 13. Hu Z, Shao M, Chen Y, Zhou J, Qian J, Xu L, et al. Allele 2 of the interleukin-1 receptor antagonist gene (IL1RN*2) is associated with a decreased risk of primary lung cancer. Cancer Lett. 2006; 236(2): 269-75[DOI][PubMed]
  • 14. Campa D, Zienolddiny S, Maggini V, Skaug V, Haugen A, Canzian F. Association of a common polymorphism in the cyclooxygenase 2 gene with risk of non-small cell lung cancer. Carcinogenesis. 2004; 25(2): 229-35[DOI][PubMed]
  • 15. Shih CM, Lee YL, Chiou HL, Hsu WF, Chen WE, Chou MC, et al. The involvement of genetic polymorphism of IL-10 promoter in non-small cell lung cancer. Lung Cancer. 2005; 50(3): 291-7[DOI][PubMed]
  • 16. Shih CM, Lee YL, Chiou HL, Chen W, Chang GC, Chou MC, et al. Association of TNF-alpha polymorphism with susceptibility to and severity of non-small cell lung cancer. Lung Cancer. 2006; 52(1): 15-20[DOI][PubMed]
  • 17. Basu S, Fenton MJ. Toll-like receptors: function and roles in lung disease. Am J Physiol Lung Cell Mol Physiol. 2004; 286(5)-92[DOI][PubMed]
  • 18. Lafferty EI, Qureshi ST, Schnare M. The role of toll-like receptors in acute and chronic lung inflammation. J Inflamm (Lond). 2010; 7: 57[DOI][PubMed]
  • 19. Chen K, Xiang Y, Yao X, Liu Y, Gong W, Yoshimura T, et al. The active contribution of Toll-like receptors to allergic airway inflammation. Int Immunopharmacol. 2011; 11(10): 1391-8[DOI][PubMed]
  • 20. Beg AA. Endogenous ligands of Toll-like receptors: implications for regulating inflammatory and immune responses. Trends Immunol. 2002; 23(11): 509-12[PubMed]
  • 21. Kokkinos P, Myers J. Exercise and physical activity: clinical outcomes and applications. Circulation. 2010; 122(16): 1637-48[DOI][PubMed]
  • 22. Lee DC, Pate RR, Lavie CJ, Sui X, Church TS, Blair SN. Leisure-time running reduces all-cause and cardiovascular mortality risk. J Am Coll Cardiol. 2014; 64(5): 472-81[DOI][PubMed]
  • 23. Ji LL. Modulation of skeletal muscle antioxidant defense by exercise: Role of redox signaling. Free Radic Biol Med. 2008; 44(2): 142-52[DOI][PubMed]
  • 24. Vieira RP, Toledo AC, Ferreira SC, Santos AB, Medeiros MC, Hage M, et al. Airway epithelium mediates the anti-inflammatory effects of exercise on asthma. Respir Physiol Neurobiol. 2011; 175(3): 383-9[DOI][PubMed]
  • 25. Pastva A, Estell K, Schoeb TR, Atkinson TP, Schwiebert LM. Aerobic exercise attenuates airway inflammatory responses in a mouse model of atopic asthma. J Immunol. 2004; 172(7): 4520-6[PubMed]
  • 26. Vieira RP, Claudino RC, Duarte AC, Santos AB, Perini A, Faria Neto HC, et al. Aerobic exercise decreases chronic allergic lung inflammation and airway remodeling in mice. Am J Respir Crit Care Med. 2007; 176(9): 871-7[DOI][PubMed]
  • 27. Vieira RP, de Andrade VF, Duarte AC, Dos Santos AB, Mauad T, Martins MA, et al. Aerobic conditioning and allergic pulmonary inflammation in mice. II. Effects on lung vascular and parenchymal inflammation and remodeling. Am J Physiol Lung Cell Mol Physiol. 2008; 295(4)-9[DOI][PubMed]
  • 28. Vieira RP, Duarte AC, Santos AB, Medeiros MC, Mauad T, Martins MA, et al. Exercise reduces effects of creatine on lung. Int J Sports Med. 2009; 30(9): 684-90[DOI][PubMed]
  • 29. Mussi RK, Camargo EA, Ferreira T, De Moraes C, Delbin MA, Toro IF, et al. Exercise training reduces pulmonary ischaemia-reperfusion-induced inflammatory responses. Eur Respir J. 2008; 31(3): 645-9[DOI][PubMed]
  • 30. Ramos DS, Olivo CR, Quirino Santos Lopes FD, Toledo AC, Martins MA, Lazo Osorio RA, et al. Low-intensity swimming training partially inhibits lipopolysaccharide-induced acute lung injury. Med Sci Sports Exerc. 2010; 42(1): 113-9[DOI][PubMed]
  • 31. Toledo AC, Magalhaes RM, Hizume DC, Vieira RP, Biselli PJ, Moriya HT, et al. Aerobic exercise attenuates pulmonary injury induced by exposure to cigarette smoke. Eur Respir J. 2012; 39(2): 254-64[DOI][PubMed]
  • 32. Campbell ME, Li Q, Gingrich SE, Macfarlane RG, Cheng S. Should people be physically active outdoors on smog alert days? Can J Public Health. 2005; 96(1): 24-8[PubMed]
  • 33. Jacobs L, Nawrot TS, de Geus B, Meeusen R, Degraeuwe B, Bernard A, et al. Subclinical responses in healthy cyclists briefly exposed to traffic-related air pollution: an intervention study. Environ Health. 2010; 9: 64[DOI][PubMed]
  • 34. Patel H, Eo S, Kwon S. Effects of diesel particulate matters on inflammatory responses in static and dynamic culture of human alveolar epithelial cells. Toxicol Lett. 2011; 200(1-2): 124-31[DOI][PubMed]
  • 35. Strak M, Boogaard H, Meliefste K, Oldenwening M, Zuurbier M, Brunekreef B, et al. Respiratory health effects of ultrafine and fine particle exposure in cyclists. Occup Environ Med. 2010; 67(2): 118-24[DOI][PubMed]
  • 36. Daigle CC, Chalupa DC, Gibb FR, Morrow PE, Oberdorster G, Utell MJ, et al. Ultrafine particle deposition in humans during rest and exercise. Inhal Toxicol. 2003; 15(6): 539-52[DOI][PubMed]
  • 37. Giles LV, Koehle MS. The health effects of exercising in air pollution. Sports Med. 2014; 44(2): 223-49[DOI][PubMed]
  • 38. Bai Y, Brugha RE, Jacobs L, Grigg J, Nawrot TS, Nemery B. Carbon loading in airway macrophages as a biomarker for individual exposure to particulate matter air pollution - A critical review. Environ Int. 2014; 74C: 32-41[DOI][PubMed]
  • 39. Zhao H, Barger MW, Ma JK, Castranova V, Ma JY. Cooperation of the inducible nitric oxide synthase and cytochrome P450 1A1 in mediating lung inflammation and mutagenicity induced by diesel exhaust particles. Environ Health Perspect. 2006; 114(8): 1253-8[PubMed]
  • 40. Zhao H, Ma JK, Barger MW, Mercer RR, Millecchia L, Schwegler-Berry D, et al. Reactive oxygen species- and nitric oxide-mediated lung inflammation and mitochondrial dysfunction in wild-type and iNOS-deficient mice exposed to diesel exhaust particles. J Toxicol Environ Health A. 2009; 72(8): 560-70[DOI][PubMed]
  • 41. Akira S, Takeda K. Toll-like receptor signalling. Nat Rev Immunol. 2004; 4(7): 499-511[DOI][PubMed]
  • 42. Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow? Lancet. 2001; 357(9255): 539-45[DOI][PubMed]
  • 43. Balkwill F, Charles KA, Mantovani A. Smoldering and polarized inflammation in the initiation and promotion of malignant disease. Cancer Cell. 2005; 7(3): 211-7[DOI][PubMed]
  • 44. Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002; 420(6917): 860-7[DOI][PubMed]
  • 45. Greten FR, Eckmann L, Greten TF, Park JM, Li ZW, Egan LJ, et al. IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell. 2004; 118(3): 285-96[DOI][PubMed]
  • 46. Luo JL, Maeda S, Hsu LC, Yagita H, Karin M. Inhibition of NF-kappaB in cancer cells converts inflammation- induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression. Cancer Cell. 2004; 6(3): 297-305[DOI][PubMed]
  • 47. Pikarsky E, Porat RM, Stein I, Abramovitch R, Amit S, Kasem S, et al. NF-kappaB functions as a tumour promoter in inflammation-associated cancer. Nature. 2004; 431(7007): 461-6[DOI][PubMed]
  • 48. Xu X, Yavar Z, Verdin M, Ying Z, Mihai G, Kampfrath T, et al. Effect of early particulate air pollution exposure on obesity in mice: role of p47phox. Arterioscler Thromb Vasc Biol. 2010; 30(12): 2518-27[DOI][PubMed]
  • 49. Ahmad T, Chasman DI, Buring JE, Lee IM, Ridker PM, Everett BM. Physical activity modifies the effect of LPL, LIPC, and CETP polymorphisms on HDL-C levels and the risk of myocardial infarction in women of European ancestry. Circ Cardiovasc Genet. 2011; 4(1): 74-80[DOI][PubMed]
  • 50. Mathur N, Pedersen BK. Exercise as a mean to control low-grade systemic inflammation. Mediators Inflamm. 2008; 2008: 109502[DOI][PubMed]
  • 51. Flynn MG, McFarlin BK. Toll-like receptor 4: link to the anti-inflammatory effects of exercise? Exerc Sport Sci Rev. 2006; 34(4): 176-81[DOI][PubMed]
  • 52. Pedersen BK, Febbraio MA. Muscle as an endocrine organ: focus on muscle-derived interleukin-6. Physiol Rev. 2008; 88(4): 1379-406[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiation Alert
via Google Reader

Readers' Comments