International Journal of Cancer Management

Published by: Kowsar

An In silico Chimeric Vaccine Targeting Breast Cancer Containing Inherent Adjuvant

Abbas Ali Imani Fooladi 1 , Hamideh Mahmoodzadeh Hosseini 1 and Jafar Amani 1 , *
Authors Information
1 Applied Microbiology Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran
Article information
  • Iranian Journal of Cancer Prevention: May 28, 2015, 8 (3); e2326
  • Published Online: May 22, 2015
  • Article Type: Research Article
  • Received: September 29, 2014
  • Revised: November 16, 2014
  • Accepted: December 14, 2014
  • DOI: 10.17795/ijcp2326

To Cite: Imani Fooladi A A, Mahmoodzadeh Hosseini H, Amani J. An In silico Chimeric Vaccine Targeting Breast Cancer Containing Inherent Adjuvant , Int J Cancer Manag. 2015 ; 8(3):e2326. doi: 10.17795/ijcp2326.

Abstract
Copyright © 2015, Iranian Journal of Cancer Prevention.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
Acknowledgements
Footnotes
References
  • 1. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010; 127(12): 2893-917[DOI][PubMed]
  • 2. Lanari C, Wargon V, Rojas P, Molinolo AA. Antiprogestins in breast cancer treatment: are we ready? Endocr Relat Cancer. 2012; 19(3)-50[DOI][PubMed]
  • 3. Soto-Cerrato V, Llagostera E, Montaner B, Scheffer GL, Perez-Tomas R. Mitochondria-mediated apoptosis operating irrespective of multidrug resistance in breast cancer cells by the anticancer agent prodigiosin. Biochem Pharmacol. 2004; 68(7): 1345-52[DOI][PubMed]
  • 4. Forrester WC, Dell M, Perens E, Garriga G. A C. elegans Ror receptor tyrosine kinase regulates cell motility and asymmetric cell division. Nature. 1999; 400(6747): 881-5[DOI][PubMed]
  • 5. Rebagay G, Yan S, Liu C, Cheung NK. ROR1 and ROR2 in Human Malignancies: Potentials for Targeted Therapy. Front Oncol. 2012; 2: 34[DOI][PubMed]
  • 6. Al-Shawi R, Ashton SV, Underwood C, Simons JP. Expression of the Ror1 and Ror2 receptor tyrosine kinase genes during mouse development. Dev Genes Evol. 2001; 211(4): 161-71[PubMed]
  • 7. Baskar S, Kwong KY, Hofer T, Levy JM, Kennedy MG, Lee E, et al. Unique cell surface expression of receptor tyrosine kinase ROR1 in human B-cell chronic lymphocytic leukemia. Clin Cancer Res. 2008; 14(2): 396-404[DOI][PubMed]
  • 8. Shabani M, Asgarian-Omran H, Vossough P, Sharifian RA, Faranoush M, Ghragozlou S, et al. Expression profile of orphan receptor tyrosine kinase (ROR1) and Wilms' tumor gene 1 (WT1) in different subsets of B-cell acute lymphoblastic leukemia. Leuk Lymphoma. 2008; 49(7): 1360-7[DOI][PubMed]
  • 9. Gentile A, Lazzari L, Benvenuti S, Trusolino L, Comoglio PM. Ror1 is a pseudokinase that is crucial for Met-driven tumorigenesis. Cancer Res. 2011; 71(8): 3132-41[DOI][PubMed]
  • 10. Zhang S, Chen L, Cui B, Chuang HY, Yu J, Wang-Rodriguez J, et al. ROR1 is expressed in human breast cancer and associated with enhanced tumor-cell growth. PLoS One. 2012; 7(3)[DOI][PubMed]
  • 11. Fooladi AA, Sattari M, Hassan ZM, Mahdavi M, Azizi T, Horii A. In vivo induction of necrosis in mice fibrosarcoma via intravenous injection of type B staphylococcal enterotoxin. Biotechnol Lett. 2008; 30(12): 2053-9[DOI][PubMed]
  • 12. Perabo FG, Willert PL, Wirger A, Schmidt DH, Wardelmann E, Sitzia M, et al. Preclinical evaluation of superantigen (staphylococcal enterotoxin B) in the intravesical immunotherapy of superficial bladder cancer. Int J Cancer. 2005; 115(4): 591-8[DOI][PubMed]
  • 13. Sen TZ, Jernigan RL, Garnier J, Kloczkowski A. GOR V server for protein secondary structure prediction. Bioinformatics. 2005; 21(11): 2787-8[DOI][PubMed]
  • 14. Zhang Y. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics. 2008; 9: 40[DOI][PubMed]
  • 15. Laskowski RA, MacArthur MW, Moss DS, Thornton JM. PROCHECK: a program to check the stereochemical quality of protein structures. J. Appl Crystal. 1993; 26(2): 283-91
  • 16. El-Manzalawy Y, Dobbs D, Honavar V. Predicting linear B-cell epitopes using string kernels. J Mol Recognit. 2008; 21(4): 243-55[DOI][PubMed]
  • 17. Ansari HR, Raghava GP. Identification of conformational B-cell Epitopes in an antigen from its primary sequence. Immunome Res. 2010; 6: 6[DOI][PubMed]
  • 18. Haste Andersen P, Nielsen M, Lund O. Prediction of residues in discontinuous B-cell epitopes using protein 3D structures. Protein Sci. 2006; 15(11): 2558-67[DOI][PubMed]
  • 19. Singh H, Raghava GP. ProPred1: prediction of promiscuous MHC Class-I binding sites. Bioinformatics. 2003; 19(8): 1009-14[PubMed]
  • 20. Singh H, Raghava GP. ProPred: prediction of HLA-DR binding sites. Bioinformatics. 2001; 17(12): 1236-7[PubMed]
  • 21. Ivanciuc O, Schein CH, Braun W. SDAP: database and computational tools for allergenic proteins. Nucleic Acids Res. 2003; 31(1): 359-62[PubMed]
  • 22. Davis GD, Elisee C, Newham DM, Harrison RG. New fusion protein systems designed to give soluble expression in Escherichia coli. Biotechnol Bioeng. 1999; 65(4): 382-8[PubMed]
  • 23. Ren J, Wen L, Gao X, Jin C, Xue Y, Yao X. DOG 1.0: illustrator of protein domain structures. Cell Res. 2009; 19(2): 271-3[DOI][PubMed]
  • 24. De Groot AS, Sbai H, Aubin CS, McMurry J, Martin W. Immuno-informatics: Mining genomes for vaccine components. Immunol Cell Biol. 2002; 80(3): 255-69[DOI][PubMed]
  • 25. He Y, Cao Z, De Groot AS, Brusic V, Schonbach C, Petrovsky N. Computational vaccinology and the ICoVax 2012 workshop. BMC Bioinformatics. 2013; 14 Suppl 4[DOI][PubMed]
  • 26. Arai R, Wriggers W, Nishikawa Y, Nagamune T, Fujisawa T. Conformations of variably linked chimeric proteins evaluated by synchrotron X-ray small-angle scattering. Proteins. 2004; 57(4): 829-38[DOI][PubMed]
  • 27. Arai R, Ueda H, Kitayama A, Kamiya N, Nagamune T. Design of the linkers which effectively separate domains of a bifunctional fusion protein. Protein Eng. 2001; 14(8): 529-32[PubMed]
  • 28. Soria-Guerra RE, Moreno-Fierros L, Rosales-Mendoza S. Two decades of plant-based candidate vaccines: a review of the chimeric protein approaches. Plant Cell Rep. 2011; 30(8): 1367-82[DOI][PubMed]
  • 29. Webb B, Sali A. Comparative Protein Structure Modeling Using MODELLER. Curr Protoc Bioinformatics. 2014; 47: 5 6 1-5 6 32[DOI][PubMed]
  • 30. Petsko GA. An introduction to modeling structure from sequence. Curr Protocols Bioinform. 2006; : 5.1. 1-3
  • 31. Negi SS, Braun W. Automated detection of conformational epitopes using phage display Peptide sequences. Bioinform Biol Insights. 2009; 3: 71-81[PubMed]
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