International Journal of Cancer Management

Published by: Kowsar

A Diagnostic Accuracy Comparison Between Tzanck Smear Test and Frozen Section Examination in Basal Cell Carcinoma

Elias Salimi 1 , 2 , Sima Nazemi 3 , Mazaher Ramezani 3 , * , Sedigheh Khazaei 3 , Afshin Almasi 4 , Yunes Shafieino 3 and Masoud Sadeghi 5
Authors Information
1 Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran
2 Department of Dermatology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
3 Molecular Pathology Research Center, Emam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran
4 Department of Biostatistics and Epidemiology, Kermanshah University of Medical Sciences, Kermanshah, Iran
5 Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
Article information
  • International Journal of Cancer Management: November 2017, 10 (11); e11510
  • Published Online: November 30, 2017
  • Article Type: Research Article
  • Received: March 19, 2017
  • Revised: May 23, 2017
  • Accepted: October 30, 2017
  • DOI: 10.5812/ijcm.11510

How to Cite: Salimi E, Nazemi S, Ramezani M, Khazaei S, Almasi A, et al. A Diagnostic Accuracy Comparison Between Tzanck Smear Test and Frozen Section Examination in Basal Cell Carcinoma, Int J Cancer Manag. 2017 ; 10(11):e11510. doi: 10.5812/ijcm.11510.

Copyright © 2017, Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Methods
3. Results
4. Discussion
  • 1. Housman TS, Feldman SR, Williford PM, Fleischer AJ, Goldman ND, Acostamadiedo JM, et al. Skin cancer is among the most costly of all cancers to treat for the Medicare population. J Am Acad Dermatol. 2003;48(3):425-9. doi: 10.1067/mjd.2003.186. [PubMed: 12637924].
  • 2. Gurudutt VV, Genden EM. Cutaneous squamous cell carcinoma of the head and neck. J Skin Cancer. 2011;2011:502723. doi: 10.1155/2011/502723. [PubMed: 21461387].
  • 3. Nicoletti G, Brenta F, Malovini A, Musumarra G, Scevola S, Faga A. Study to determine whether intraoperative frozen section biopsy improves surgical treatment of non-melanoma skin cancer. Mol Clin Oncol. 2013;1(2):390-4. doi: 10.3892/mco.2012.51. [PubMed: 24649181].
  • 4. Sengul D, Sengul I, Astarci MH, Ustun H, Mocan G. CD10 for the distinct differential diagnosis of basal cell carcinoma and benign tumours of cutaneous appendages originating from hair follicle. Pol J Pathol. 2010;61(3):140-6. [PubMed: 21225496].
  • 5. Jaafar H. Intra-operative frozen section consultation: concepts, applications and limitations. Malays J Med Sci. 2006;13(1):4-12. [PubMed: 22589584].
  • 6. Lane JE, Kent DE. Surgical margins in the treatment of nonmelanoma skin cancer and mohs micrographic surgery. Curr Surg. 2005;62(5):518-26. doi: 10.1016/j.cursur.2005.01.003. [PubMed: 16125611].
  • 7. Menesi W, Buchel EW, Hayakawa TJ. A reliable frozen section technique for basal cell carcinomas of the head and neck. Plast Surg (Oakv). 2014;22(3):179-82. doi: 10.4172/plastic-surgery.1000870. [PubMed: 25332646].
  • 8. Kong K, Rowlands CJ, Varma S, Perkins W, Leach IH, Koloydenko AA, et al. Diagnosis of tumors during tissue-conserving surgery with integrated autofluorescence and Raman scattering microscopy. Proc Natl Acad Sci U S A. 2013;110(38):15189-94. doi: 10.1073/pnas.1311289110. [PubMed: 24003124].
  • 9. Bogdanov-Berezovsky A, Rosenberg L, Cagniano E, Silberstein E. The role of frozen section histological analysis in the treatment of head and neck skin basal and squamous cell carcinomas. Isr Med Assoc J. 2008;10(5):344-5. [PubMed: 18605355].
  • 10. Rohaizak M, Munchar MJ, Meah FA, Jasmi AY. Prospective study comparing scrape cytology with frozen section in the intraoperative identification of parathyroid tissue. Asian J Surg. 2005;28(2):82-5. doi: 10.1016/S1015-9584(09)60267-0. [PubMed: 15851358].
  • 11. Yaeen A, Ahmad QM, Farhana A, Shah P, Hassan I. Diagnostic value of Tzanck smear in various erosive, vesicular, and bullous skin lesions. Indian Dermatol Online J. 2015;6(6):381-6. doi: 10.4103/2229-5178.169729. [PubMed: 26751561].
  • 12. Wong VA, Marshall JA, Whitehead KJ, Williamson RM, Sullivan TJ. Management of periocular basal cell carcinoma with modified en face frozen section controlled excision. Ophthal Plast Reconstr Surg. 2002;18(6):430-5. doi: 10.1097/01.IOP.0000029717.47962.C4. [PubMed: 12439056].
  • 13. Mohs FE. Micrographic surgery for the microscopically controlled excision of eyelid cancers. Arch Ophthalmol. 1986;104(6):901-9. doi: 10.1001/archopht.1986.01050180135046. [PubMed: 3718316].
  • 14. Kvannli L, Benger R, Gal A, Swamy B. The method of en face frozen section in clearing periocular basal cell carcinoma and squamous cell carcinoma. Orbit. 2012;31(4):233-7. doi: 10.3109/01676830.2012.679170. [PubMed: 22671704].
  • 15. Manstein ME, Manstein CH, Smith R. How accurate is frozen section for skin cancers?. Ann Plast Surg. 2003;50(6):607-9. doi: 10.1097/01.SAP.0000069073.38391.91. [PubMed: 12783011].
  • 16. Pluot M, Ducasse A. [Pathology in the diagnosis and treatment of palpebral tumors]. J Fr Ophtalmol. 2003;26(1):77-83. [PubMed: 12610415].
  • 17. Luo D, Ha J, Latham B, Ingram D, Connell T, Hastrich D, et al. The accuracy of intraoperative subareolar frozen section in nipple-sparing mastectomies. Ochsner J. 2010;10(3):188-92. [PubMed: 21603376].
  • 18. Eryilmaz A, Durdu M, Baba M, Yildirim FE. Diagnostic reliability of the Tzanck smear in dermatologic diseases. Int J Dermatol. 2014;53(2):178-86. doi: 10.1111/j.1365-4632.2012.05662.x. [PubMed: 23557278].
  • 19. Durdu M, Baba M, Seckin D. Dermatoscopy versus Tzanck smear test: a comparison of the value of two tests in the diagnosis of pigmented skin lesions. J Am Acad Dermatol. 2011;65(5):972-82. doi: 10.1016/j.jaad.2010.08.019. [PubMed: 21565420].
  • 20. Bakis S, Irwig L, Wood G, Wong D. Exfoliative cytology as a diagnostic test for basal cell carcinoma: a meta-analysis. Br J Dermatol. 2004;150(5):829-36. doi: 10.1111/j.1365-2133.2004.05716.x. [PubMed: 15149493].
  • 21. Baba M, Durdu M, Seckin D. A useful alternative approach for the treatment of well-demarcated Basal cell carcinoma: surgical excision and margin control with tzanck smear test. Dermatol Surg. 2010;36(5):659-64. doi: 10.1111/j.1524-4725.2010.01525.x. [PubMed: 20384747].
  • 22. Ruocco E, Brunetti G, Del Vecchio M, Ruocco V. The practical use of cytology for diagnosis in dermatology. J Eur Acad Dermatol Venereol. 2011;25(2):125-9. doi: 10.1111/j.1468-3083.2010.03740.x. [PubMed: 20553359].
  • 23. Dey V, Thawani M, Dubey N. Accuracy and reliability of Tzanck test compared to histopathology for diagnosis of basal cell carcinoma. Indian J Dermatopathol Diagn Dermatol. 2015;2(1):8-13. doi: 10.4103/2349-6029.160980.
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