Hepatitis-C Infection Incidence Among the non-Hodgkin’s B-cell Lymphoma Patients in the Northeast of Iran

AUTHORS

Seyed Amir Aledavood 1 , Mohammad Reza Ghavam-Nasir 1 , Kamran Ghaffarzadegan 1 , Hamid Reza Raziee 1 , Golnaz Saboori 2 , Kazem Anvari 1 , Samira Mohtashami 1 , Mitra Ahadi 1 , Bahram Memar 1 , *

1 Dept. of Radiation oncology, Cancer Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

2 Dept. of Radiation oncology, Cancer Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Andorra

How to Cite: Aledavood S A , Ghavam-Nasir M R, Ghaffarzadegan K, Raziee H R, Saboori G, et al. Hepatitis-C Infection Incidence Among the non-Hodgkin’s B-cell Lymphoma Patients in the Northeast of Iran, Int J Cancer Manag. 2014 ; 7(3):e80544.

ARTICLE INFORMATION

International Journal of Cancer Management: 7 (3); e80544
Published Online: September 30, 2014
Article Type: Research Article
Received: April 16, 2014
Accepted: June 22, 2014

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Abstract

Background: Various infectious agents like Ebstein Barr Virus (EBV), HTLV-1 and Helicobacter pylori have known as etiologic factors in different sub-types of lymphoma. Although Hepatitis C virus (HCV) has not only been important for its hepatotropism and hepatitis development, but also in recent years its association with some forms of non- Hodgkin’s lymphoma (NHL), especially B cell NHL, has reported. In some countries, the rate of B cell NHL development in HCV infected patients was four times more than general population, and then association between HCV infection and B-NHL has proposed in many studies.

Methods: To assess this relationship in our geographic region, in a descriptive study; we have evaluated patients with B-NHL in an oncology center in northeast of Iran for HCV infection.

Results: Out of 128 B-NHL patients, HCV Antibody test (with third generation ELISA method) was positive in only one patient, which confirmed with Nested PCR technique. Then the frequency of HCV infection in our patients was 0.7%.

Conclusion: Respecting to the incidence of HCV infection in general population in Iran, which is between 0.5-1%, we couldn’t show higher prevalence of HCV infection in NHL patients than general population, and hence couldn’t confirm relation between HCV infection and B-NHL in our region.

Keywords

Hepatitis C non-Hodgkin’s lymphoma B-cell Epidemiology

© 2014, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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