Granzyme H Serum Levels Variations with Both Reproductive Hormone Receptors, and Related Hormone Receptors in Breast Cancer Patients

AUTHORS

Behnoosh Tahbaz-lahaf 1 , MohammadEsmaeil Akbari 2 , * , Houshang Amir-Rassouli 1 , Ali Rahimipour 1 , Eznollah Azargashb 2 , Nahid Nafissi 2 , Farida Jahani 2

1 Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2 Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

How to Cite: Tahbaz-lahaf B, Akbari M, Amir-Rassouli H, Rahimipour A, Azargashb E, et al. Granzyme H Serum Levels Variations with Both Reproductive Hormone Receptors, and Related Hormone Receptors in Breast Cancer Patients, Int J Cancer Manag. 2014 ; 7(1):e80509.

ARTICLE INFORMATION

International Journal of Cancer Management: 7 (1); e80509
Published Online: March 31, 2014
Article Type: Research Article
Received: November 02, 2013
Accepted: December 21, 2013

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Abstract

Background: Breast Cancer (BC) is the most common cancer in Iranian women, meanwhile the Iranian patients are relatively young. Granzyme H (GZMH) is a functional cytotoxic serine protease of NK cell granules, which expands the cell death-inducing repertoire of innate immune system. GZMH is constitutively and highly expressed in human NK cells, in order to possess chymotrypsin-like (chymase) enzymatic activity. The purpose of this study was to determine GZMH level, in BC and healthy women.

Methods: 30 breast cancer patients, and 30 control women in premenopausal status, have participated in this study. GZMH, Estrogen levels, and ER, PR have been measured in cancer and healthy women subsequently, as using ELISA, Radioimmunoassay, and Immunohistochemistry methods.

Results: Mean GZMH value was lower in BC than healthy women (p<0.0001).

Conclusion: Our study has implicated existence of suppressor or problem for producing of GZMH in patients group and levels of estrogen couldn’t effect on making positive ER, PR.

Keywords

Breast Cancer Estrogen Granzyme H

© 2014, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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