Diagnosis of Post-Radiotherapy Local Failures in Nasopharyngeal Carcinoma: A Prospective Institutional Study

AUTHORS

Puneet Bagri 1 , * , Mukesh Singhal 1 , Daleep Singh 1 , Akhil Kapoor 1 , Shankar Lal Jakhar 1 , Neeti Sharma 1 , Surender Beniwal 2 , Harvindra Kumar 1 , Ajay Sharma 1 , Megh Bardia 1

1 Dept. of Radiation Oncology, Acharya Tulsi Regional Cancer Treatment & Research Institute, Bikaner-334003, Rajasthan, India

2 Medical Oncology section, Acharya Tulsi Regional Cancer Treatment & Research Institute, Bikaner-334003, Rajasthan, India

How to Cite: Bagri P, Singhal M, Singh D, Kapoor A, Lal Jakhar S, et al. Diagnosis of Post-Radiotherapy Local Failures in Nasopharyngeal Carcinoma: A Prospective Institutional Study, Int J Cancer Manag. 2014 ; 7(1):e80507.

ARTICLE INFORMATION

International Journal of Cancer Management: 7 (1); e80507
Published Online: March 31, 2014
Article Type: Research Article
Received: October 26, 2013
Accepted: December 02, 2013

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Abstract

Background: This prospective study was conducted to evaluate and compare the efficacies of nasopharyngoscopy and CT scan in the diagnosis of local failure of external beam radiotherapy (EBRT) for nasopharyngeal carcinoma. Methods: Total 52 patients of histopathologically proven nasopharyngeal carcinoma treated with external beam radiotherapy (EBRT), were included in this study. For every patient computed tomography (CT), nasopharyngoscopy and nasopharyngeal biopsies were performed 3 months after completion of EBRT.

Results: Three months after completion of EBRT, 9 patients (17.3%) had evident disease on histological examination of biopsies. Nasopharyngoscopy showed 77.78% sensitivity, 93.03% specificity, 70% positive predictive value and 95.24% negative predictive value in diagnosing the residual/recurrence of tumor. There was statistically significant agreement between the endoscopic findings and the histological findings (Kappa reliability coefficient=0.562, p0.05). Conclusion: Nasopharyngoscopy should be considered the primary follow-up tool after radiotherapy of nasopharyngeal carcinoma. CT scan should be reserved for patients with histological or any symptomatic indications. Routine postnasal biopsies are not required.

Keywords

Nasopharyngeal carcinoma Local failure Nasopharyngoscopy CT scan Biopsy

© 2014, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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