The Stromal Overexpression of CD10 in Invasive Breast Cancer and its Association with Clincophathologic Factors

AUTHORS

Ali Taghizadeh-Kermani 1 , Amir Hossein Jafarian 2 , * , Reza Ashabyamin 3 , Mehdi Seilanian-Toosi 4 , Leila Pourali 5 , Mehdi Asadi 6 , Leila Mashhadi 7

1 Surgical Oncology Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Cancer Research Center, Omid Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

2 Cancer Molecular Pathology Research Center, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

3 Dept. of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

4 Cancer Research Center, Omid Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

5 Women's Health Research Center, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

6 Surgical Oncology Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

7 Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

How to Cite: Taghizadeh-Kermani A, Jafarian A H , Ashabyamin R, Seilanian-Toosi M, Pourali L, et al. The Stromal Overexpression of CD10 in Invasive Breast Cancer and its Association with Clincophathologic Factors, Int J Cancer Manag. 2014 ; 7(1):e80503.

ARTICLE INFORMATION

International Journal of Cancer Management: 7 (1); e80503
Published Online: March 31, 2014
Article Type: Research Article
Received: August 20, 2013
Accepted: October 25, 2013

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Abstract

Background: Breast carcinoma is the most common non-skin malignancy in women. More recently, it has been suggested that extracellular proteinase has also regulated growth factors and cytokines that might contribute to tumor progression. CD10 is a 90-110kd cell surface zinc-dependent metalloproteinase. Since CD10 is structurally similar to matrix metalloproteinase and stromelysin, it might facilitate cancer cell invasion and/or metastasis. The aim of this study was investigation the rate of CD10 expression in the stromal cells of invasive ductal breast carcinomas, Immunohistochemical aspects, then any other aspects to be able to clarify its correlation with other clinicopathological factors of this disease.

Methods: One hundred patients with histopathologic diagnosis of invasive ductal carcinoma and 50 patients with fibroadenoma of breast (as the control group) have selected, then 150 paraffin blocks have obtained. The stained slides by immunohistochemistry method for CD10 marker have examined separately by two pathologists, and discrepancies have reviewed in common session to get the final result.

Results: Stromal CD10 has detected in 28% of the IDC. No kind of immunoreactivity has identified in the stromal cells of normal breast. Stromal CD10 expression in IDC has significantly correlated with increasing tumor size (p<0.001), increasing histologic grade (p<0.001), the presence of nodal metastases (p<0.001) and estrogen receptor negative status (p=0.003).

Conclusion: Stromal CD10 expression in IDC has closely correlated with invasion and metastasis and it might play an important role in the pathogenesis of IDC.

Keywords

CD10 Immunohistochemistry Breast carcinoma Stromal cell

© 2014, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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