Severe Hypertension and Encephalopathy Due to Renin-Producing Hepatoblastoma

AUTHORS

Azita Tavasoli 1 , * , Mitra Mehrazma 2 , Nakisa Hooman 3 , Ladan Afshar Khas 1

1 Dept. of Pediatric Neurology, Ali Asghar Hospital, Tehran University of Medical Sciences, Tehran, Iran

2 Oncopathology Research Center, Tehran University of Medical Sciences, Tehran, Iran

3 Dept. of Pediatrics Nephrology, Ali Asghar Hospital, Tehran University of Medical Sciences, Tehran, Iran

How to Cite: Tavasoli A, Mehrazma M, Hooman N, Afshar Khas L. Severe Hypertension and Encephalopathy Due to Renin-Producing Hepatoblastoma, Int J Cancer Manag. 2013 ; 6(4):e80483.

ARTICLE INFORMATION

International Journal of Cancer Management: 6 (4); e80483
Published Online: December 30, 2013
Article Type: Case Report
Received: January 06, 2011
Accepted: March 28, 2011

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Abstract

Paraneoplastic syndromes result from secretion of hormones, peptides or cytokines by tumor or immune cross-reactivity between malignant and normal tissues. These conditions are rare in children, but when the clinical presentation of patients with a tumor is unusual, these syndromes should be emphasized. Extrarenal tumors with renin-secretion are rare in children. They may be related to paraneoplastic syndromes. We report a 22-month-old infant with hepatoblastoma presented with severe hypertension and related neurologic symptoms due to high plasma renin activity. To the best of our knowledge, this is the second report of renin producing hepatoblastoma in the literature. However, due to lack of laboratory facilities such as immunohistochemical study or polyclonal antibody for human renin activity, we could not prove the secretion of renin just by tumor tissue cells, but this potentiality is very likely. Other intensive investigations did not show any other origin for rennin secretion or hypertension in this patient.

Keywords

Hepatoblastoma Hypertension Paraneoplastic syndromes Renin

© 2013, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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