Genomic and Epigenetic Instability in Colorectal Cancer

AUTHORS

Akram Safaei 1 , Sara Sobhi 2 , Mostafa Rezaei Tavirani 3 , * , Mohammad Reza Zali 4

1 Students' Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2 Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

3 Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

4 Gastroentrology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

How to Cite: Safaei A, Sobhi S, Rezaei Tavirani M , Zali M R. Genomic and Epigenetic Instability in Colorectal Cancer, Int J Cancer Manag. 2013 ; 6(Supplement):e80473.

ARTICLE INFORMATION

International Journal of Cancer Management: 6 (Supplement); e80473
Published Online: December 30, 2013
Article Type: Review Article
Received: October 19, 2012
Accepted: December 24, 2012

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Abstract

Colorectal Cancer (CRC) is the third most common cancer in men and the second most common cancer in women worldwide. Both genetic and epigenetic alterations are common in CRC and are the driving force of tumorigenesis. Chromosomal instability, microsatellite instability and CpG island methylator phenotype pathways are responsible for genetic instability in colorectal cancer. Chromosomal instability pathway consists of activation of proto-oncogenes and inactivation of tumor suppression genes and Loss of Heterozogosity (LOH). In this review, we discuss genetic and epigenetic phenomena that can be suggested as biomarkers in colorectal cancer

Keywords

Epigenomics Genetic Colorectal cancer

© 2013, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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