Aqueous Extract of Lavender Angustifolia Inhibits Lymphocytes Proliferation of Hodgkin's Lymphoma Patients

AUTHORS

Sona Dalilan 1 , Mostafa Rezaei Tavirani 2 , * , Mohammad Nabiuni 3 , Saeed Heidari-Keshel 2 , Mona Zamanian Azodi 2 , Hakimeh Zali 2

1 Science and Research Branch, Islamic Azad University, Tehran, Iran

2 Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

3 Dept. of Biology, Faculty of Basic Sciences, Tarbiat Moallem University, Tehran, Iran

How to Cite: Dalilan S, Rezaei Tavirani M , Nabiuni M, Heidari-Keshel S, Zamanian Azodi M, et al. Aqueous Extract of Lavender Angustifolia Inhibits Lymphocytes Proliferation of Hodgkin's Lymphoma Patients, Int J Cancer Manag. 2013 ; 6(4):e80471.

ARTICLE INFORMATION

International Journal of Cancer Management: 6 (4); e80471
Published Online: December 30, 2013
Article Type: Research Article
Received: June 01, 2013
Accepted: July 02, 2013

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Abstract

Background: There are several types of cancer, which cause millions of deaths worldwide every year. Many studies have confirmed that plants are adequate natural sources to be examined as anti-cancer drugs with fewer side effects than chemotherapy and radiotherapy. In this study the anti-cancer properties of Lavender aqueous extract on lymphocytes derived from patients with Hodgkin's lymphoma has been studied.

Methods: In order to determine the cytotoxic effects of the extract on lymphocytes of patients in stages III and IV of Hodgkin's lymphoma and two different cell lines in the presence of different concentrations of aqueous extract of Lavender, MTT colorimetric assay and flow cytometry analysis were used.

Results: Findings indicated that Lavender inhibited cell proliferation in both lymphocytes and cell lines with different effects. The effective concentration of Lavender that decreased viability of Hodgkin's lymphoma cells below Lethal Concentration 50 (LC50) value was 100 µg/ml and this was half of the therapeutic dose. In addition, apoptosis was the main mechanism the Hodgkin's lymphoma cell encountered when exposed to the aqueous extract of Lavender.

Conclusion: This experiment proposes that aqueous Lavender extract can be regarded as a potential anti-cancer agent in future studies.

Keywords

Lavandula Lymphocytes Hodgkin's lymphoma Cytotoxicity Cell lines

© 2013, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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