Breast Cancer Biomarker Discovery: Proteomics and Genomics Approaches

AUTHORS

Akram Safaei 1 , Mostafa Rezaei‐Tavirani 1 , Sara Sobhi 2 , MohammadEsmaeil Akbari 2 , *

1 Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2 Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

How to Cite: Safaei A, Rezaei‐Tavirani M, Sobhi S, Akbari M. Breast Cancer Biomarker Discovery: Proteomics and Genomics Approaches, Int J Cancer Manag. 2013 ; 6(Supplement):e80465.

ARTICLE INFORMATION

International Journal of Cancer Management: 6 (Supplement); e80465
Published Online: December 30, 2013
Article Type: Review Article
Received: September 27, 2012
Accepted: November 19, 2012

Crossmark

CHEKING

READ FULL TEXT
Abstract

Breast cancer is one of the major health problems of the Eastern world. Regardless of the survival rate improvement with progression in screening and adjuvant systemic therapies, still one – third of the patients with primary breast cancer have recurrence of micro metastasis after 10 years. It is important to discover a reliable biomarker for detection of breast cancer. The underlying molecular mechanism of the disease needs to be better understood. Allied to genomics, proteomics technologies promise to be valuable for identifying new markers that improve screening, early diagnosis, prognosis and prediction of therapeutic response or toxicity, as well as the identification of new therapeutic targets. In this review, we present proteomic and genomic sciences have been used for differential analysis of breast cancer to find molecular changes of cancer for detection candidate biomarkers.

Keywords

Breast cancer Biological Markers Proteomics Genomics

© 2013, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

Fulltext

The Full text is available in PDF.

COMMENTS

LEAVE A COMMENT HERE: