The Association between Polymorphismsin Insulin and Obesity Related Genesand Risk of Colorectal Cancer

AUTHORS

Mostafa Rezaei Tavirani 1 , * , Akram Safaei 2 , Mohammad Reza Zali 2

1 Proteomics Research Center, Faculty of Paramedical Sciences, Shahid BeheshtiUniversity of Medical Sciences, Tehran, Iran

2 Gastroentrology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

How to Cite: Rezaei Tavirani M , Safaei A, Zali M R. The Association between Polymorphismsin Insulin and Obesity Related Genesand Risk of Colorectal Cancer, Int J Cancer Manag. 2013 ; 6(4):e80463.

ARTICLE INFORMATION

International Journal of Cancer Management: 6 (4); e80463
Published Online: December 30, 2013
Article Type: Review Article
Received: June 17, 2013
Accepted: July 02, 2013

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Abstract

Colon cancer is the cancer of the large intestine (colon), which is located in the lower part of digestive system. Colon cancer is the third most common cancer in men and the second in women worldwide. Genetic background is thought to play a role in modulating individual risks of this cancer. Many studies support an association between insulin pathway gene polymorphisms and regulation of tumor cell biology in colorectal cancer. This review examines the role of polymorphisms of insulin and obesity pathway genes (IGFs, INS, INSR, ADIPOQ, ADIPOQR, LEP and LEPR) in development of colorectal cancer.

Keywords

Insulin Obesity Colorectal cancer

© 2013, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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