Risk Factors of Developing a Second Malignancy Following Treatment of a First Primary Breast Cancer

AUTHORS

Ahmad Rezazadeh Mafi 1 , Shadi Babazadeh 2 , Fatemeh Homaee Shandiz 3 , Zahra Razzaghi 1 , Morteza Tabatabaeefar 4 , Sara Sobhi 1 , Mohammad Esmaeil Akbari 1 , *

1 Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2 Dept. of Radiation Oncology, Isfahan University of Medical Sciences, Isfahan, Iran

3 Cancer Research Center, Omid Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

4 Jorjani Cancer Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

How to Cite: Rezazadeh Mafi A, Babazadeh S, Homaee Shandiz F, Razzaghi Z, Tabatabaeefar M, et al. Risk Factors of Developing a Second Malignancy Following Treatment of a First Primary Breast Cancer, Int J Cancer Manag. 2013 ; 6(Supplement):e80453.

ARTICLE INFORMATION

International Journal of Cancer Management: 6 (Supplement); e80453
Published Online: December 30, 2013
Article Type: Research Article
Received: October 17, 2012
Accepted: December 06, 2012

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Abstract

Background: Breast cancer is the most prevalent cancer among Iranian women, and is the fifth cause of cancer-related death in Iran. Most studies have reported an overall excess of 20–30% chance for a second primary cancer to develop in individuals with a first breast cancer. In this study, we evaluated different factors might have a role in increasing the incidence of a second malignancy after a first primary breast cancer in Iran.

Methods: We considered 980 breast cancer patients from three cancer research centers in Tehran, Mashad and Isfahan from Sep 1995 till Sep 2010.

Results: Overall, 94 second primary neoplasms observed. This analysis showed the existence of a modest excess in several neoplasms occurring after breast cancer. Some treatment related factors, including radiotherapy or mastectomy, had statistically significant relation with development a secondary cancer. However, sub-analysis failed to prove such a relationship.

Conclusion: Therefore, we can concluded that the risk of developing a second cancer is more dependent on genetic and environmental factors that caused the first primary cancer, rather than being dependent on type of treatment and other factors mentioned in this study.

Keywords

Breast cancer Second primary Therapy Iran

© 2013, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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