Hedgehog Signalling Pathway: Carcinogenesis and Targeted Therapy

AUTHORS

Abdolali Ebrahimi 1 , * , L Larijani 2 , A Moradi 2 , MR Ebrahimi 3

1 Dept. of Pathology, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2 Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

3 Red Crescent Society of Islamic Republic of Iran, Tehran, Iran

How to Cite: Ebrahimi A, Larijani L, Moradi A, Ebrahimi M. Hedgehog Signalling Pathway: Carcinogenesis and Targeted Therapy, Int J Cancer Manag. 2013 ; 6(1):e80384.

ARTICLE INFORMATION

International Journal of Cancer Management: 6 (1); e80384
Published Online: March 30, 2013
Article Type: Review Article
Received: April 22, 2012
Accepted: July 24, 2012

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Abstract

Hedgehog signalling pathway has not only a critical role in cell proliferation, differentiation and tissue polarity at embryonic period but also has a vital role in stem cell proliferation, tissue healing and carcinogenesis. Recent research has increased our understanding of this pathway and its relation to other signalling pathways. In addition, a large number of studies confirmed the alteration of Hh signalling pathway in various types of human malignancies including basal cell carcinomas, medulloblastomas, lung, gastrointestinal, ovarian, breast, prostate cancers and leukemia. More than 50 small biomolecules have been introduced which have inhibitory effects on Hh signalling pathway. Although, in many tumors some acceptable results have been showed in phase I clinical trial, closer studies are required to improve drug bioavailability, to decrease the side effects and to find the right small molecules for specific types of cancers, considering patients overall benefits as well.

Keywords

Hedgehog Neoplasm Molecular targeted therapy

© 2013, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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