International Journal of Cancer Management

Published by: Kowsar

Inhibitory Effects of Cichorium Intybus Root Extract on the Proliferation and Lipogenesis of the SKBR3 Cells

Reza Mehrandish 1 , Nasrin Dehghan-Nayeri 2 , Aliasghar Rahimian 1 , Ali Toutounchi 3 and Ali Mellati 1 , *
Authors Information
1 Zanjan Metabolic Diseases Research Center and Biochemistry Department, Zanjan University of Medical Sciences, Zanjan, Iran
2 Proteomics Research Center, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3 Department of Clinical Biochemistry, Tehran University of Medical Sciences, Tehran, Iran
Article information
  • International Journal of Cancer Management: April 2018, 11 (4); e9436
  • Published Online: April 30, 2018
  • Article Type: Research Article
  • Received: October 22, 2016
  • Revised: April 15, 2017
  • Accepted: February 27, 2018
  • DOI: 10.5812/ijcm.9436

To Cite: Mehrandish R, Dehghan-Nayeri N, Rahimian A, Toutounchi A, Mellati A. Inhibitory Effects of Cichorium Intybus Root Extract on the Proliferation and Lipogenesis of the SKBR3 Cells, Int J Cancer Manag. 2018 ; 11(4):e9436. doi: 10.5812/ijcm.9436.

Copyright © 2018, Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Tian WX. Inhibition of fatty acid synthase by polyphenols. Curr Med Chem. 2006;13(8):967-77. [PubMed: 16611078].
  • 2. Street RA, Sidana J, Prinsloo G. Cichorium intybus: Traditional Uses, Phytochemistry, Pharmacology, and Toxicology. Evid Based Complement Alternat Med. 2013;2013:579319. doi: 10.1155/2013/579319. [PubMed: 24379887].
  • 3. Berndt J, Kovacs P, Ruschke K, Kloting N, Fasshauer M, Schon MR, et al. Fatty acid synthase gene expression in human adipose tissue: association with obesity and type 2 diabetes. Diabetologia. 2007;50(7):1472-80. doi: 10.1007/s00125-007-0689-x. [PubMed: 17492427].
  • 4. Wakil SJ, Stoops JK, Joshi VC. Fatty acid synthesis and its regulation. Annu Rev Biochem. 1983;52:537-79. doi: 10.1146/ [PubMed: 6137188].
  • 5. Vazquez-Martin A, Colomer R, Brunet J, Menendez JA. Pharmacological blockade of fatty acid synthase (FASN) reverses acquired autoresistance to trastuzumab (Herceptin by transcriptionally inhibiting 'HER2 super-expression' occurring in high-dose trastuzumab-conditioned SKBR3/Tzb100 breast cancer cells. Int J Oncol. 2007;31(4):769-76. [PubMed: 17786307].
  • 6. Cairns RA, Harris IS, Mak TW. Regulation of cancer cell metabolism. Nat Rev Cancer. 2011;11(2):85-95. doi: 10.1038/nrc2981. [PubMed: 21258394].
  • 7. Sugino T, Baba K, Hoshi N, Aikawa K, Yamaguchi O, Suzuki T. Overexpression of fatty acid synthase in human urinary bladder cancer and combined expression of the synthase and Ki-67 as a predictor of prognosis of cancer patients. Med Mol Morphol. 2011;44(3):146-50. doi: 10.1007/s00795-010-0517-0. [PubMed: 21922386].
  • 8. Alo PL, Visca P, Marci A, Mangoni A, Botti C, Di Tondo U. Expression of fatty acid synthase (FAS) as a predictor of recurrence in stage I breast carcinoma patients. Cancer. 1996;77(3):474-82. [PubMed: 8630954].
  • 9. Dehghan-Nayeri N, Gharehbaghian A, Goudarzi Pour K, Eshghi P. Over expression of the fatty acid synthase is a strong predictor of poor prognosis and contributes to glucocorticoid resistance in b-cell acute lymphoblastic leukemia. World Canc Res J. 2016;3(3).
  • 10. Chuang HY, Chang YF, Hwang JJ. Antitumor effect of orlistat, a fatty acid synthase inhibitor, is via activation of caspase-3 on human colorectal carcinoma-bearing animal. Biomed Pharmacother. 2011;65(4):286-92. doi: 10.1016/j.biopha.2011.02.016. [PubMed: 21723078].
  • 11. Brusselmans K, Vrolix R, Verhoeven G, Swinnen JV. Induction of cancer cell apoptosis by flavonoids is associated with their ability to inhibit fatty acid synthase activity. J Biol Chem. 2005;280(7):5636-45. doi: 10.1074/jbc.M408177200. [PubMed: 15533929].
  • 12. Saleem M, Abbas K, Naseer F, Ahmad M, Javed F, Hussain K, et al. Anticancer activity of n-hexane extract of Cichorium intybus on lymphoblastic leukemia cells (Jurkat cells). Afr J Plant Sci. 2014;8(6):315-9.
  • 13. Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 2001;29(9). e45. [PubMed: 11328886].
  • 14. Mehrandish R, Mellati AA, Rahimipour A, Dehghan Nayeri N. Anti-Cancer activity of methanol extracts of Cichorium intybus on Human Breast Cancer SKBR3 Cell Line (2016). Razavi Int J Med.
  • 15. Menendez JA, Lupu R. Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat Rev Cancer. 2007;7(10):763-77. doi: 10.1038/nrc2222. [PubMed: 17882277].
  • 16. Fonseca-Alaniz MH, Takada J, Alonso-Vale MI, Lima FB. Adipose tissue as an endocrine organ: from theory to practice. J Pediatr (Rio J). 2007;83(5 Suppl):S192-203. doi: 10.2223/JPED.1709. [PubMed: 17989837].
  • 17. Tavasoli M, Ghaedi K, Tavasoli Z, Sadeghi M. Signal transduction for cancer treatment. Genetics in the Third Millennium. 2007;4(4). Persian.
  • 18. Esmaeilbeig M, Kouhpayeh SA, Amirghofran Z. An Investigation of the Growth Inhibitory Capacity of Several Medicinal Plants From Iran on Tumor Cell Lines. Iran J Cancer Prev. 2015;8(5). e4032. doi: 10.17795/ijcp-4032. [PubMed: 26634114].
  • 19. Gospodinova Z, Krasteva M. Cichorium intybus L. from Bulgaria inhibits viability of human breast cancer cells in vitro. Genet Plant Physiol. 2015;5(1):15-22.
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