International Journal of Cancer Management

Published by: Kowsar

Changes in pH and Sodium Salivary Bicarbonate Among Patients with Acute Myeloid Leukemia Before and After Chemotherapy

Shamsoulmolouk Najafi 1 , Mina Khayamzadeh 2 , Soheila Manifar 1 , Asma Khaki 3 and Narges Gholizadeh ORCID 1 , *
Authors Information
1 Department of Oral and Maxillofacial Disease, Tehran University of Medical Sciences, Tehran, Iran
2 Department of Oral and Maxillofacial Disease, International Campus, Tehran University of Medical Sciences, Tehran, Iran
3 Dentist, Tehran, Iran
Article information
  • International Journal of Cancer Management: 12 (2); e83449
  • Published Online: February 26, 2019
  • Article Type: Research Article
  • Received: August 19, 2018
  • Revised: January 19, 2019
  • Accepted: January 26, 2019
  • DOI: 10.5812/ijcm.83449

How to Cite: Najafi S , Khayamzadeh M, Manifar S , Khaki A, Gholizadeh N. Changes in pH and Sodium Salivary Bicarbonate Among Patients with Acute Myeloid Leukemia Before and After Chemotherapy, Int J Cancer Manag. Online ahead of Print ; 12(2):e83449. doi: 10.5812/ijcm.83449.

Copyright © 2019, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Agha-Hosseini F, Mirzaii-Dizgah I, Mansourian A, Zabihi-Akhtechi G. Serum and stimulated whole saliva parathyroid hormone in menopausal women with oral dry feeling. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;107(6):806-10. doi: 10.1016/j.tripleo.2009.01.024. [PubMed: 19386515].
  • 2. Agha-Hosseini F, Mirzaii-Dizgah I, Mansourian A, Khayamzadeh M. Relationship of stimulated saliva 17beta-estradiol and oral dryness feeling in menopause. Maturitas. 2009;62(2):197-9. doi: 10.1016/j.maturitas.2008.10.016. [PubMed: 19144478].
  • 3. Kaplan JB. Biofilm dispersal: Mechanisms, clinical implications, and potential therapeutic uses. J Dent Res. 2010;89(3):205-18. doi: 10.1177/0022034509359403. [PubMed: 20139339]. [PubMed Central: PMC3318030].
  • 4. Frenkel ES, Ribbeck K. Salivary mucins in host defense and disease prevention. J Oral Microbiol. 2015;7:29759. doi: 10.3402/jom.v7.29759. [PubMed: 26701274]. [PubMed Central: PMC4689954].
  • 5. Frenkel ES, Ribbeck K. Salivary mucins protect surfaces from colonization by cariogenic bacteria. Appl Environ Microbiol. 2015;81(1):332-8. doi: 10.1128/AEM.02573-14. [PubMed: 25344244]. [PubMed Central: PMC4272720].
  • 6. Nunes LA, Brenzikofer R, Macedo DV. Reference intervals for saliva analytes collected by a standardized method in a physically active population. Clin Biochem. 2011;44(17-18):1440-4. doi: 10.1016/j.clinbiochem.2011.09.012. [PubMed: 21986592].
  • 7. Liu J, Duan Y. Saliva: A potential media for disease diagnostics and monitoring. Oral Oncol. 2012;48(7):569-77. doi: 10.1016/j.oraloncology.2012.01.021. [PubMed: 22349278].
  • 8. Lee YH, Wong DT. Saliva: An emerging biofluid for early detection of diseases. Am J Dent. 2009;22(4):241-8. [PubMed: 19824562]. [PubMed Central: PMC2860957].
  • 9. de Oliveira Lula EC, de Oliveira Lula CE, Alves CM, Lopes FF, Pereira AL. Chemotherapy-induced oral complications in leukemic patients. Int J Pediatr Otorhinolaryngol. 2007;71(11):1681-5. doi: 10.1016/j.ijporl.2007.07.006. [PubMed: 17850887].
  • 10. Jawed M, Shahid SM, Qader SA, Azhar A. Dental caries in diabetes mellitus: Role of salivary flow rate and minerals. J Diabetes Complications. 2011;25(3):183-6. doi: 10.1016/j.jdiacomp.2010.07.001. [PubMed: 20801061].
  • 11. Jakubovics NS. Saliva as the sole nutritional source in the development of multispecies communities in dental plaque. Microbiol Spectr. 2015;3(3). doi: 10.1128/microbiolspec.MBP-0013-2014. [PubMed: 26185065].
  • 12. de Almeida Pdel V, Gregio AM, Machado MA, de Lima AA, Azevedo LR. Saliva composition and functions: A comprehensive review. J Contemp Dent Pract. 2008;9(3):72-80. [PubMed: 18335122].
  • 13. Sulkala M, Wahlgren J, Larmas M, Sorsa T, Teronen O, Salo T, et al. The effects of MMP inhibitors on human salivary MMP activity and caries progression in rats. J Dent Res. 2001;80(6):1545-9. doi: 10.1177/00220345010800061301. [PubMed: 11499510].
  • 14. Liukkonen J, Gursoy UK, Kononen E, Gursoy M, Metso J, Salminen A, et al. Salivary biomarkers in association with periodontal parameters and the periodontitis risk haplotype. Innate Immun. 2018;24(7):439-47. doi: 10.1177/1753425918796207. [PubMed: 30176756].
  • 15. Vuotila T, Ylikontiola L, Sorsa T, Luoto H, Hanemaaijer R, Salo T, et al. The relationship between MMPs and pH in whole saliva of radiated head and neck cancer patients. J Oral Pathol Med. 2002;31(6):329-38. doi: 10.1034/j.1600-0714.2002.310603.x. [PubMed: 12190815].
  • 16. Rojas de Morales T, Navas R, Viera N, Alvarez CJ, Chaparro N, Griman D. pH and salivary sodium bicarbonate during the administration protocol for methotrexate in children with leukemia. Med Oral Patol Oral Cir Bucal. 2007;12(6):E435-9. [PubMed: 17909509].
  • 17. Bardow A, Moe D, Nyvad B, Nauntofte B. The buffer capacity and buffer systems of human whole saliva measured without loss of CO2. Arch Oral Biol. 2000;45(1):1-12. doi: 10.1016/S0003-9969(99)00119-3. [PubMed: 10669087].
  • 18. Aranibar Quiroz EM, Alstad T, Campus G, Birkhed D, Lingstrom P. Relationship between plaque pH and different caries-associated variables in a group of adolescents with varying caries prevalence. Caries Res. 2014;48(2):147-53. doi: 10.1159/000355614. [PubMed: 24401692].
  • 19. Chifor I, Badea I, Chifor R, Popa D, Staniste L, Tarmure D, et al. Saliva characteristics, diet and carioreceptivity in dental students. Clujul Med. 2014;87(1):34-9. doi: 10.15386/cjm.2014.8872.871.ic1ib2. [PubMed: 26527994]. [PubMed Central: PMC4462414].
  • 20. Ertugrul F, Elbek-Cubukcu C, Sabah E, Mir S. The oral health status of children undergoing hemodialysis treatment. Turk J Pediatr. 2003;45(2):108-13. [PubMed: 12921296].
  • 21. Al-Nowaiser A, Roberts GJ, Trompeter RS, Wilson M, Lucas VS. Oral health in children with chronic renal failure. Pediatr Nephrol. 2003;18(1):39-45. doi: 10.1007/s00467-002-0999-7. [PubMed: 12488989].
  • 22. Mealina R, Moran E, Regalado M, Bergado G. La saliva comomedio de diagnostico de HIV. Rev Cubana Estomatol. 2000;37:146-56.
  • 23. Kaufman E, Lamster IB. The diagnostic applications of saliva--a review. Crit Rev Oral Biol Med. 2002;13(2):197-212. doi: 10.1177/154411130201300209. [PubMed: 12097361].
  • 24. Vissink A, Jansma J, Spijkervet FK, Burlage FR, Coppes RP. Oral sequelae of head and neck radiotherapy. Crit Rev Oral Biol Med. 2003;14(3):199-212. doi: 10.1177/154411130301400306. [PubMed: 12799323].
  • 25. Gholizadeh N, Mehdipour M, Chavoshi SH, Kahani S, Sadrzadeh-Afshar MS. The effect of orally-administered zinc in the prevention of chemotherapy-induced oral mucositis in patients with acute myeloid leukemia. Int J Cancer Manag. 2017;10(8). e9252. doi: 10.5812/ijcm.9252.
  • 26. Kawahara M, Pandolfi A, Bartholdy B, Barreyro L, Will B, Roth M, et al. H2.0-like homeobox regulates early hematopoiesis and promotes acute myeloid leukemia. Cancer Cell. 2012;22(2):194-208. doi: 10.1016/j.ccr.2012.06.027. [PubMed: 22897850]. [PubMed Central: PMC3422691].
  • 27. Kumar CC. Genetic abnormalities and challenges in the treatment of acute myeloid leukemia. Genes Cancer. 2011;2(2):95-107. doi: 10.1177/1947601911408076. [PubMed: 21779483]. [PubMed Central: PMC3111245].
  • 28. Juarez-Lopez MLA, Solano-Silva MN, Fragoso-Rios R, Murrieta-Pruneda F. Oral diseases in children with acute lymphoblastic leukemia with chemotherapy treatment. Rev Med Inst Mex Seguro Soc. 2018;56(2):132-5. [PubMed: 29901909].
  • 29. Dobbs J, Barrett A, Ash D. Practical radiotherapy planning. London: Arnold; 1999. p. 2407-13.
  • 30. Schubert MM, Izutsu KT. Iatrogenic causes of salivary gland dysfunction. J Dent Res. 1987;66 Spec No:680-8. doi: 10.1177/00220345870660S213. [PubMed: 3305644].
  • 31. Taheri M, Najafi MH, Salehi MH. [Clinical evaluation of the effects of radiotherapy on oral mucosa and gingival health in radiotherapy of Ghaem Hospital]. J Mashhad Dent Sch. 2006;30(1-2):87-98. Persian.
  • 32. Ghavam M. [Oral lesions following radiation therapy and their preventive considerations]. J Dent Tehran Univ Med Sci. 2001;14(27):60-7. Persian.
  • 33. Navazesh M, Kumar SK, University of Southern California School of D. Measuring salivary flow: Challenges and opportunities. J Am Dent Assoc. 2008;139 Suppl:35S-40S. doi: 10.14219/jada.archive.2008.0353. [PubMed: 18460678].
  • 34. Gonsalves WC, Wrightson AS, Henry RG. Common oral conditions in older persons. Am Fam Physician. 2008;78(7):845-52. [PubMed: 18841733].
  • 35. Rojas-Morales T, Navas R, Viera N, Alvarez CJ, Chaparro N. pH and salivary sodium bicarbonate in cancer patients: Correlation with seric concentration. Med Oral Patol Oral Cir Bucal. 2008;13(7):E456-9. [PubMed: 18587311].
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