International Journal of Cancer Management

Published by: Kowsar

Opium Use and Risk of Lower Gastrointestinal Cancers: Population-Based Case-Control Study in South of Iran

Kamran B. lankarani 1 , Zahra Khosravizadegan 2 , Ahmad Naghibzadeh-Tahami 3 , Mojtaba Akbari 4 , Mahmoud Khodadost 5 , 6 , Behnam Honarvar 1 , Behnam Khodadost 7 , Forough Goodarzi 7 , Kimia Jokari 7 , Maryam Akbari 9 , Eghbal Sekhavati 8 and Reza Tabrizi 9 , *
Authors Information
1 Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, IR Iran
2 Department of Cancer Surveillance, Deputy of Health, Shiraz University of Medical Sciences, Shiraz, IR Iran
3 Physiology Research Center,Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
4 Department of Epidemiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IR Iran
5 Department of Epidemiology, Faculty of Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6 Department of Epidemiology, Faculty of Health, Iran University of Medical Sciences, Tehran, IR Iran
7 Department of Public Health, Faculty of Health, Shiraz University of Medical Sciences, Shiraz, IR Iran
8 Larestan School of Medical Sciences, Larestan, IR Iran
9 Health Policy Research Center, Institute of Health, Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
Article information
  • International Journal of Cancer Management: June 2017, 10 (6); e8227
  • Published Online: June 30, 2017
  • Article Type: Research Article
  • Received: August 12, 2016
  • Accepted: May 13, 2017
  • DOI: 10.5812/ijcm.8227

To Cite: lankarani K B, Khosravizadegan Z, Naghibzadeh-Tahami A, Akbari M, Khodadost M, et al. Opium Use and Risk of Lower Gastrointestinal Cancers: Population-Based Case-Control Study in South of Iran, Int J Cancer Manag. 2017 ; 10(6):e8227. doi: 10.5812/ijcm.8227.

Copyright © 2017, International Journal of Cancer Management. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Masoompour SM, Yarmohammadi H, Rezaianzadeh A, Lankarani KB. Cancer incidence in southern Iran, 1998-2002: results of population-based cancer registry. Cancer Epidemiol. 2011; 35(5)-7[DOI][PubMed]
  • 2. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010; 127(12): 2893-917[DOI][PubMed]
  • 3. Fakheri H, Janbabai GH, Bari Z, Eshqi F. The epidemiologic and clinical-pathologic characteristics of colorectal cancers from 1999 to 2007 in Sari, Iran. J Mazandaran Univ Med Sci. 2008; 18(67): 58-66
  • 4. Masoompour SM, Lankarani KB, Honarvar B, Tabatabaee SH, Moghadami M, Khosravizadegan Z. Changing Epidemiology of Common Cancers in Southern Iran, 2007-2010: A Cross Sectional Study. PLoS One. 2016; 11(5)[DOI][PubMed]
  • 5. Fateh SH, Amini M. An epidemiologic study of colorectal cancer in Arak during 1994-2004. Iran J Surg. 2008; 2(16): 11-7
  • 6. Mousavi SM, Gouya MM, Ramazani R, Davanlou M, Hajsadeghi N, Seddighi Z. Cancer incidence and mortality in Iran. Ann Oncol. 2009; 20(3): 556-63[DOI][PubMed]
  • 7. Bishehsari F, Mahdavinia M, Vacca M, Malekzadeh R, Mariani-Costantini R. Epidemiological transition of colorectal cancer in developing countries: environmental factors, molecular pathways, and opportunities for prevention. World J Gastroenterol. 2014; 20(20): 6055-72[DOI][PubMed]
  • 8. Malekzadeh R, Bishehsari F, Mahdavinia M, Ansari R. Epidemiology and molecular genetics of colorectal cancer in iran: a review. Arch Iran Med. 2009; 12(2): 161-9[PubMed]
  • 9. Roya N, Abbas B. Colorectal cancer trends in Kerman province, the largest province in Iran, with forecasting until 2016. Asian Pac J Cancer Prev. 2013; 14(2): 791-3[PubMed]
  • 10. Azadeh S, Moghimi-Dehkordi B, Fatem SR, Pourhoseingholi MA, Ghiasi S, Zali MR. Colorectal cancer in Iran: an epidemiological study. Asian Pac J Cancer Prev. 2008; 9(1): 123-6[PubMed]
  • 11. Semnani SH, Kazeminezhad V, Abd EN. The epidemiological aspect of colorectal cancer in Gorgan. J Gorgan Uni Med Sci. 2003; 5(2): 13-8
  • 12. Ansari R, Mahdavinia M, Sadjadi A, Nouraie M, Kamangar F, Bishehsari F, et al. Incidence and age distribution of colorectal cancer in Iran: results of a population-based cancer registry. Cancer Lett. 2006; 240(1): 143-7[DOI][PubMed]
  • 13. Fazeli MS, Adel MG, Lebaschi AH. Colorectal carcinoma: a retrospective, descriptive study of age, gender, subsite, stage, and differentiation in Iran from 1995 to 2001 as observed in Tehran University. Dis Colon Rectum. 2007; 50(7): 990-5[DOI][PubMed]
  • 14. Parkin DM. International variation. Oncogene. 2004; 23(38): 6329-40[DOI][PubMed]
  • 15. Hasanzadeh J, Hosseini Nezhad Z, Vardanjani M, Farahmand M. Gender differences in esophagus, stomach, colon and rectum cancers in fars, Iran, during 2009-2010: an epidemiological population based study. J Rafsanjan Univ Med Sci. 2013; 12(5): 333-42
  • 16. Doubeni CA, Major JM, Laiyemo AO, Schootman M, Zauber AG, Hollenbeck AR, et al. Contribution of behavioral risk factors and obesity to socioeconomic differences in colorectal cancer incidence. J Natl Cancer Inst. 2012; 104(18): 1353-62[DOI][PubMed]
  • 17. Doubeni CA, Laiyemo AO, Major JM, Schootman M, Lian M, Park Y, et al. Socioeconomic status and the risk of colorectal cancer: an analysis of more than a half million adults in the National Institutes of Health-AARP Diet and Health Study. Cancer. 2012; 118(14): 3636-44[DOI][PubMed]
  • 18. Botteri E, Iodice S, Raimondi S, Maisonneuve P, Lowenfels AB. Cigarette smoking and adenomatous polyps: a meta-analysis. Gastroenterology. 2008; 134(2): 388-95[DOI][PubMed]
  • 19. Chan DS, Lau R, Aune D, Vieira R, Greenwood DC, Kampman E, et al. Red and processed meat and colorectal cancer incidence: meta-analysis of prospective studies. PLoS One. 2011; 6(6)[DOI][PubMed]
  • 20. Chao A, Thun MJ, Connell CJ, McCullough ML, Jacobs EJ, Flanders WD, et al. Meat consumption and risk of colorectal cancer. JAMA. 2005; 293(2): 172-82[DOI][PubMed]
  • 21. Cho E, Smith-Warner SA, Ritz J, van den Brandt PA, Colditz GA, Folsom AR, et al. Alcohol intake and colorectal cancer: a pooled analysis of 8 cohort studies. Ann Intern Med. 2004; 140(8): 603-13[PubMed]
  • 22. Kamangar F, Shakeri R, Malekzadeh R, Islami F. Opium use: an emerging risk factor for cancer? Lancet Oncol. 2014; 15(2)-77[DOI][PubMed]
  • 23. Malekzadeh MM, Khademi H, Pourshams A, Etemadi A, Poustchi H, Bagheri M, et al. Opium use and risk of mortality from digestive diseases: a prospective cohort study. Am J Gastroenterol. 2013; 108(11): 1757-65[DOI][PubMed]
  • 24. Naghibzadeh Tahami A, Khanjani N, Yazdi Feyzabadi V, Varzandeh M, Haghdoost AA. Opium as a risk factor for upper gastrointestinal cancers: a population-based case-control study in Iran. Arch Iran Med. 2014; 17(1): 2-6[PubMed]
  • 25. Masjedi MR, Naghan PA, Taslimi S, Yousefifard M, Ebrahimi SM, Khosravi A, et al. Opium could be considered an independent risk factor for lung cancer: a case-control study. Respiration. 2013; 85(2): 112-8[DOI][PubMed]
  • 26. Mousavi MR, Damghani MA, Haghdoust AA, Khamesipour A. Opium and risk of laryngeal cancer. Laryngoscope. 2003; 113(11): 1939-43[PubMed]
  • 27. Akbari M, Naghibzadeh-Tahami A, Khanjani N, Baneshi MR, Kamali E, Hesampour M, et al. Opium as a Risk Factor for Bladder Cancer: A Population-based Case-control Study in Iran. Arch Iran Med. 2015; 18(9): 567-71[PubMed]
  • 28. Esophageal cancer studies in the Caspian littoral of Iran: results of population studies--a prodrome. Joint Iran-International Agency for Research on Cancer Study Group. J Natl Cancer Inst. 1977; 59(4): 1127-38[PubMed]
  • 29. Momtazi S, Rawson R. Substance abuse among Iranian high school students. Curr Opin Psychiatry. 2010; 23(3): 221-6[DOI][PubMed]
  • 30. Shakeri R, Malekzadeh R, Etemadi A, Nasrollahzadeh D, Aghcheli K, Sotoudeh M, et al. Opium: an emerging risk factor for gastric adenocarcinoma. Int J Cancer. 2013; 133(2): 455-61[DOI][PubMed]
  • 31. Bashardoost N, Tirani M. Prevalence of addiction in males: Isfahan 2003. ARYA Atheroscler. 2010; 1(2)
  • 32. Naghibzadeh-Tahami A, Feyzabadi VY, Khanjani N, Ashrafi-Asgarabad A, Alizaeh H, Borhaninejad VR, et al. Can Opium Use Contribute to a Higher Risk of Colorectal Cancers? A Matched Case-control Study in Iran. Iranian journal of public health. 2016; 45(10): 1322-31[PubMed]
  • 33. Abnet CC, Saadatian-Elahi M, Pourshams A, Boffetta P, Feizzadeh A, Brennan P, et al. Reliability and validity of opiate use self-report in a population at high risk for esophageal cancer in Golestan, Iran. Cancer Epidemiol Biomarkers Prev. 2004; 13(6): 1068-70[PubMed]
  • 34. Sadeghi A, Behmard S, Vesselinovitch SD. Opium: a potential urinary bladder carcinogen in man. Cancer. 1979; 43(6): 2315-21[PubMed]
  • 35. Baeg MK, Choi MG, Jung YD, Ko SH, Lim CH, Kim HH, et al. Esophageal Squamous Cell Carcinoma Patients Have an Increased Risk of Coexisting Colorectal Neoplasms. Gut Liver. 2016; 10(1): 76-82[DOI][PubMed]
  • 36. Friesen M, O'Neill IK, Malaveille C, Garren L, Hautefeuille A, Cabral JR, et al. Characterization and identification of 6 mutagens in opium pyrolysates implicated in oesophageal cancer in Iran. Mutat Res. 1985; 150(1-2): 177-91[PubMed]
  • 37. Perry PE, Thomson EJ, Evans HJ, Day NE, Bartsch H. Induction of SCE by opium pyrolysates in CHO cells and human peripheral blood lymphocytes. Carcinogenesis. 1983; 4(2): 227-30[PubMed]
  • 38. Hewer T, Rose E, Ghadirian P, Castegnaro M, Malaveille C, Bartsch H, et al. Ingested mutagens from opium and tobacco pyrolysis products and cancer of the oesophagus. Lancet. 1978; 2(8088): 494-6[PubMed]
  • 39. Lankarani KB. Opium, an oncogene or a marker of oncogenic behaviors? Am J Gastroenterol. 2014; 109(4): 600[DOI][PubMed]
  • 40. Jung YS, Ryu S, Chang Y, Yun KE, Park JH, Kim HJ, et al. Risk factors for colorectal neoplasia in persons aged 30 to 39 years and 40 to 49 years. Gastrointest Endosc. 2015; 81(3): 637-645 e7[DOI][PubMed]
  • 41. Kim KS, Moon HJ, Choi CH, Baek EK, Lee SY, Cha BK, et al. The Frequency and Risk Factors of Colorectal Adenoma in Health-Check-up Subjects in South Korea: Relationship to Abdominal Obesity and Age. Gut Liver. 2010; 4(1): 36-42[DOI][PubMed]
  • 42. Moshfeghi K, Mohammad-Beigi A, Hamedi-Sanani D, Bahrami M. Evaluation the role of nutritional and individual factors in colorectal cancer. Zahedan J Res Med Sci. 2011; 13(4): 12-7
  • 43. Chen J, Ma J, Stampfer MJ, Hines LM, Selhub J, Hunter DJ. Alcohol dehydrogenase 3 genotype is not predictive for risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev. 2001; 10(12): 1303-4[PubMed]
  • 44. Tsong WH, Koh WP, Yuan JM, Wang R, Sun CL, Yu MC. Cigarettes and alcohol in relation to colorectal cancer: the Singapore Chinese Health Study. Br J Cancer. 2007; 96(5): 821-7[DOI][PubMed]
  • 45. Cross AJ, Ferrucci LM, Risch A, Graubard BI, Ward MH, Park Y, et al. A large prospective study of meat consumption and colorectal cancer risk: an investigation of potential mechanisms underlying this association. Cancer Res. 2010; 70(6): 2406-14[DOI][PubMed]
  • 46. Norat T, Bingham S, Ferrari P, Slimani N, Jenab M, Mazuir M, et al. Meat, fish, and colorectal cancer risk: the European Prospective Investigation into cancer and nutrition. J Natl Cancer Inst. 2005; 97(12): 906-16[DOI][PubMed]
  • 47. Shakeri R, Kamangar F, Nasrollahzadeh D, Nouraie M, Khademi H, Etemadi A, et al. Is opium a real risk factor for esophageal cancer or just a methodological artifact? Hospital and neighborhood controls in case-control studies. PLoS One. 2012; 7(3)[DOI][PubMed]
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