International Journal of Cancer Management

Published by: Kowsar

Cytotoxic Effect of Emodin on Growth of SKBR3 Breast Cancer Cells

Maryam Rezapour Kalkhoran 1 , Faranak Kazerouni 1 , * , Mir Davood Omrani 3 , Ali Rahimipour 1 , Mehrnoosh Shanaki 1 , Nasrin Dehghan-Nayeri 4 , Farzaneh Ahmadi 2 , Ommolbanin Younesian 1 and Fatemeh Cheshmi 1
Authors Information
1 Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
2 Department of Biostatistics, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
3 Department of Medical Genetics, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
4 Proteomics Research Center, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
Article information
  • International Journal of Cancer Management: April 2017, 10 (4); e8094
  • Published Online: March 26, 2017
  • Article Type: Research Article
  • Received: August 9, 2016
  • Revised: September 11, 2016
  • Accepted: March 14, 2017
  • DOI: 10.5812/ijcm.8094

To Cite: Rezapour Kalkhoran M, Kazerouni F, Omrani M D, Rahimipour A, Shanaki M, et al. Cytotoxic Effect of Emodin on Growth of SKBR3 Breast Cancer Cells, Int J Cancer Manag. 2017 ; 10(4):e8094. doi: 10.5812/ijcm.8094.

Abstract
Copyright © 2017, International Journal of Cancer Management. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
Acknowledgements
Footnotes
References
  • 1. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin. 2012; 62(1): 10-29[DOI][PubMed]
  • 2. Jazayeri SB, Saadat S, Ramezani R, Kaviani A. Incidence of primary breast cancer in Iran: Ten-year national cancer registry data report. Cancer Epidemiol. 2015; 39(4): 519-27[DOI][PubMed]
  • 3. Hosseini A, Ghorbani A. Cancer therapy with phytochemicals: evidence from clinical studies. Avicenna J Phytomed. 2015; 5(2): 84-97[PubMed]
  • 4. Wu TS, Jiang ZS, Meng CY. Pharmacosomes of Emodin in Improving Paraplegia in Traumatic Spinal Cord Injury Rat Model. J Biomaterials Tissue Engin. 2015; 5(12): 991-5[DOI]
  • 5. Wei WT, Lin SZ, Liu DL, Wang ZH. The distinct mechanisms of the antitumor activity of emodin in different types of cancer (Review). Oncol Rep. 2013; 30(6): 2555-62[DOI][PubMed]
  • 6. Kurebayashi J. Biological and clinical significance of HER2 overexpression in breast cancer. Breast Cancer. 2001; 8(1): 45-51[PubMed]
  • 7. Thacker PC, Karunagaran D. Curcumin and emodin down-regulate TGF-beta signaling pathway in human cervical cancer cells. PLoS One. 2015; 10(3)[DOI][PubMed]
  • 8. Liu B, Yuan B, Zhang L, Mu W, Wang C. ROS/p38/p53/Puma signaling pathway is involved in emodin-induced apoptosis of human colorectal cancer cells. Int J Clin Exp Med. 2015; 8(9): 15413-22[PubMed]
  • 9. Ying J, Xu H, Wu D, Wu X. Emodin induces apoptosis of human osteosarcoma cells via mitochondria- and endoplasmic reticulum stress-related pathways. Int J Clin Exp Pathol. 2015; 8(10): 12837-44[PubMed]
  • 10. Wang C, Dai X, Liu H, Yi H, Zhou D, Liu C, et al. Involvement of PPARgamma in emodin-induced HK-2 cell apoptosis. Toxicol In Vitro. 2015; 29(1): 228-33[DOI][PubMed]
  • 11. Xie MJ, Ma YH, Miao L, Wang Y, Wang HZ, Xing YY, et al. Emodin-provoked oxidative stress induces apoptosis in human colon cancer HCT116 cells through a p53-mitochondrial apoptotic pathway. Asian Pac J Cancer Prev. 2014; 15(13): 5201-5[PubMed]
  • 12. Agnihotri AK, Aruoma OI, Bahorun T. Cancer: Global health perspectives. Arch Med Biomed Res. 2014; 1(1): 1-9
  • 13. Liao GS, Apaya MK, Shyur LF. Herbal medicine and acupuncture for breast cancer palliative care and adjuvant therapy. Evid Based Complement Alternat Med. 2013; 2013: 437948[DOI][PubMed]
  • 14. Richard TS, Kamdje AHN, Mukhtar F. Medicinal plants in breast cancer therapy. J Dis Med Plants. 2015; 1: 19-23
  • 15. Chen YC, Shen SC, Lee WR, Hsu FL, Lin HY, Ko CH, et al. Emodin induces apoptosis in human promyeloleukemic HL-60 cells accompanied by activation of caspase 3 cascade but independent of reactive oxygen species production. Biochem Pharmacol. 2002; 64(12): 1713-24[PubMed]
  • 16. Su YT, Chang HL, Shyue SK, Hsu SL. Emodin induces apoptosis in human lung adenocarcinoma cells through a reactive oxygen species-dependent mitochondrial signaling pathway. Biochem Pharmacol. 2005; 70(2): 229-41[DOI][PubMed]
  • 17. Debatin KM. Apoptosis pathways in cancer and cancer therapy. Cancer Immunol Immunother. 2004; 53(3): 153-9[DOI][PubMed]
  • 18. Westhoff MA, Karpel-Massler G, Bruhl O, Enzenmuller S, La Ferla-Bruhl K, Siegelin MD, et al. A critical evaluation of PI3K inhibition in Glioblastoma and Neuroblastoma therapy. Mol Cell Ther. 2014; 2: 32[DOI][PubMed]
  • 19. Liu DL, Bu H, Li H, Chen H, Guo HC, Wang ZH, et al. Emodin reverses gemcitabine resistance in pancreatic cancer cells via the mitochondrial apoptosis pathway in vitro. Int J Oncol. 2012; 40(4): 1049-57[DOI][PubMed]
  • 20. Zu C, Zhang M, Xue H, Cai X, Zhao L, He A, et al. Emodin induces apoptosis of human breast cancer cells by modulating the expression of apoptosis-related genes. Oncol Lett. 2015; 10(5): 2919-24[DOI][PubMed]
  • 21. Yu CX, Zhang XQ, Kang LD, Zhang PJ, Chen WW, Liu WW, et al. Emodin induces apoptosis in human prostate cancer cell LNCaP. Asian J Androl. 2008; 10(4): 625-34[DOI][PubMed]
  • 22. Chun-Guang W, Jun-Qing Y, Bei-Zhong L, Dan-Ting J, Chong W, Liang Z, et al. Anti-tumor activity of emodin against human chronic myelocytic leukemia K562 cell lines in vitro and in vivo. Eur J Pharmacol. 2010; 627(1-3): 33-41[DOI][PubMed]
  • 23. Ma L, Li W. Emodin inhibits LOVO colorectal cancer cell proliferation via the regulation of the Bcl-2/Bax ratio and cytochrome c. Exp Ther Med. 2014; 8(4): 1225-8[DOI][PubMed]
  • 24. Miyata Y, Sakai H. Predictive Markers for the Recurrence of Nonmuscle Invasive Bladder Cancer Treated with Intravesical Therapy. Dis Markers. 2015; 2015: 857416[DOI][PubMed]
  • 25. Giotakis AI, Kontos CK, Manolopoulos LD, Sismanis A, Konstadoulakis MM, Scorilas A. High BAX/BCL2 mRNA ratio predicts favorable prognosis in laryngeal squamous cell carcinoma, particularly in patients with negative lymph nodes at the time of diagnosis. Clin Biochem. 2016; 49(12): 890-6[DOI][PubMed]
  • 26. Anvari K, Seilanian Toussi M, Kalantari M, Naseri S, Karimi Shahri M, Ahmadnia H, et al. Expression of Bcl-2 and Bax in advanced or metastatic prostate carcinoma. Urol J. 2012; 9(1): 381-8[PubMed]
  • 27. Wang C, Wu X, Chen M, Duan W, Sun L, Yan M, et al. Emodin induces apoptosis through caspase 3-dependent pathway in HK-2 cells. Toxicology. 2007; 231(2-3): 120-8[DOI][PubMed]
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