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Association of Interleukin‐10 Promoter Polymorphism   (‐1082 G/A) and Gastric Cancer in Andhra Pradesh Population of South India 

AUTHORS

Amar Chand‐Bhaya 1 , Devulapalli Krishnaveni 1 , Kondadasula Pandu‐Ranga‐Rao 2 , Boddu Prabhakar 2 , Abbagani Vidyasagar 3 , Bal Murali‐Krishna 2 , Penchikala Anita 2 , Akka Jyothy 1 , Pratibha Nallari 4 , Ananthapur Venkateshwari 1 , *

1 Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad, India

2 Dept. of Gastroenterology, Osmania General Hospital, Dr. NTR University of Health Sciences, Hyderabad, India

3 Dept. of Gastroenterology, Gandhi Hospital, Dr. NTR University of Health Sciences, Sec-bad, India

4 Dept. of Genetics, Osmania University, Hyderabad, India

How to Cite: Chand‐Bhaya A, Krishnaveni D, Pandu‐Ranga‐Rao K, Prabhakar B, Vidyasagar A, et al. Association of Interleukin‐10 Promoter Polymorphism   (‐1082 G/A) and Gastric Cancer in Andhra Pradesh Population of South India , Int J Cancer Manag. 2012 ; 5(3):e80812.

ARTICLE INFORMATION

International Journal of Cancer Management: 5 (3); e80812
Published Online: September 30, 2012
Article Type: Research Article
Received: January 18, 2012
Accepted: April 07, 2012

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Abstract

Background: Gastric Cancer (GC) is one of the most commonly diagnosed malignancies. Genetic variation in genes encoding cytokines and their receptors, determine the intensity of the inflammatory response, which may contribute to individual differences in the outcome and severity of the disease. Interleukin-10 (IL-10) is a multifunctional cytokine with both immunosuppressive and antiangiogenic functions. Polymorphisms in the IL-10 gene promoter genetically determine inter-individual differences in IL-10 production. In the present study, we investigated the association between the IL-10 –1082 G/A polymorphism and the susceptibility to gastric cancer in a South Indian population from Andhra Pradesh.

Methods: We genotyped 100 patients diagnosed with gastric cancer and 132 healthy control subjects for -1082G/A single nucleotide polymorphism by Amplification Refractory Mutation System-Polymerase Chain Reaction (ARMS-PCR) method followed by agarose gel electrophoresis.

Results: The distribution of IL-10 genotypes at -1082 G/A were GG 18 %, GA 35% and AA 47 % in gastric cancer patients and GG 31.82 %, GA 37.88 % and AA 30.3% in control subjects. The allelic frequencies of G and A were 0.355 and 0.645 in GC patients and 0.508 and 0.492 in control subjects respectively. The IL-10 -1082 A allele was associated with risk of gastric cancer (OR=1.873, 95%CI-1.285-2.73and P= 0.001048**).

Conclusion: Our study indicates that allele A of IL-10-1082 G/A polymorphism may be considered as one of the important risk factor in the etiology of gastric cancer

Keywords

Cytokines Interleukin-10 Gastric cancer Polymorphism

© 2012, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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