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Human Papilloma Virus in Head and Neck Squamous Cell Cancer

AUTHORS

I Asvadi Kermani 1 , Sharareh Seifi 1 , * , R Dolatkhah 1 , E Sakhinia 2 , S Dastgiri 3 , A Ebrahimi 1 , A Lotfy 4 , HA Esmaeili 5 , G Mohammadi 4 , M Naderpour 4 , SH Hajalipour 4 , A Asghari Haggi 1 , M Nadri 1

1 Haematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

2 Dept. of Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

3 Dept. of Social Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

4 Dept. of ENT, Tabriz University of Medical Sciences, Tabriz, Iran

5 Dept. of Pathology, Tabriz University of Medical Sciences, Tabriz, Iran

How to Cite: Asvadi Kermani I, Seifi S , Dolatkhah R, Sakhinia E, Dastgiri S, et al. Human Papilloma Virus in Head and Neck Squamous Cell Cancer, Int J Cancer Manag. 2012 ; 5(1):e80792.

ARTICLE INFORMATION

International Journal of Cancer Management: 5 (1); e80792
Published Online: March 31, 2012
Article Type: Research Article
Received: November 02, 2011
Accepted: December 03, 2011

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Abstract

Background: Epidemiologic and molecular evidences have established a strong link between high risk types of Human Papilloma Virus and a subgroup of Head and Neck Squamous Cell Carcinomas (HNSCC). We evaluated the frequency of HPV positivity in HNSCC and its relationship to demographic and some risk factor variables in an open casecontrol study.

Methods: Fourteen recently diagnosed patients with squamous cell cancer of oropharynx, hypopharynx and larynx aged 18-50 years were examined from 2008-2010 in Tabriz, Iran. HPV DNA was extracted from paraffin-embedded blocks of each patient's sample for PCR evaluation. Saliva samples of 94 control cancer-free subjects were collected for DNA analysis. Multivariable logistic regression method was used to calculate odds ratio for case-control comparisons.

Results: High risk HPV was detected in 6(42.8%) patients, and 6(5.3%) control subjects which was statistically significant (p<0.0001). HPV-18 was the most frequent type both in the cases and controls. HPV-16 DNA was detected in two patients of the case group, but it was not detected in any of the controls. The relation between demographic and risk factor variables was not statistically significant.

Conclusion: HPV infection has a significant impact on HNSCC. Despite HPV-16 stronger impact, HPV-18 is more likely to cause malignant degeneration in such cancers amongst some communities. It is vital to introduce and conduct immunization schedules in health care systems to protect communities to some extent.

Keywords

Head and Neck Neoplasms Squamous Cell Carcinoma Human Papilloma Virus 16 Human Papilloma Virus 18 Sex

© 2012, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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