OCT-4, an Embryonic Stem Cell Marker Expressed in Breast, Brain and Thyroid Carcinomas Compared to Testicular Carcinoma

AUTHORS

Zahra Madjd 1 , * , F Hashemi 2 , N Shayanfar 3 , E Farahani 4 , AH Zarnani 5 , AM Sharifi 6 , ME Akbari 7

1 Dep Pathology, Iran University of Medical Sciences; Cellular Molecular Research Centre, Iran University of Medical Sciences; Oncopathology Research Centre, Iran University of Medical Sciences; Cancer Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2 Dep Pathology, Iran University of Medical Sciences; Oncopathology Research Centre, Iran University of Medical Sciences, Tehran, Iran

3 Dep Pathology, Iran University of Medical Sciences, Tehran, Iran

4 Oncopathology Research Centre, Iran University of Medical Sciences, Tehran, Iran

5 Nanotechnology Research Center, Avicenna Research Institute, ACECR; Immunology Research Center, Iran University of Medical Sciences, Tehran, Iran

6 Cellular Molecular Research Centre, Iran University of Medical Sciences; Dep of Pharmacology, Iran University of Medical Sciences, Tehran, Iran, Iran

7 Cancer Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran

How to Cite: Madjd Z, Hashemi F, Shayanfar N, Farahani E, Zarnani A, et al. OCT-4, an Embryonic Stem Cell Marker Expressed in Breast, Brain and Thyroid Carcinomas Compared to Testicular Carcinoma , Int J Cancer Manag. 2009 ; 2(4):e80635.

ARTICLE INFORMATION

International Journal of Cancer Management: 2 (4); e80635
Published Online: December 30, 2009
Article Type: Research Article
Received: October 19, 2009
Accepted: November 24, 2009

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Abstract

Introduction: Cancer stem cells are a small subpopulation of cells within a tumor which are responsible for maintaining the tumor mass. A number of factors such as OCT-4 that govern the fate of adult stem cells also play a role in malignant cell transformation. OCT-4 is a key regulator of self-renewal in embryonic stem cells; its expression is potentially correlated with tumorigenesis and can affect some aspects of tumor behavior such as tumor recurrence or resistance to therapies.

Methods: We have investigated the potential expression of OCT-4 on a panel of tumors including breast, brain, thyroid and testicular carcinomas, using immunohistochemistry. The level of expression of OCT-4 was then compared to different tumor types and degree of differentiation.

Results: OCT-4 was expressed at the highest levels on nuclear site of seminoma compared with other tumors. The expression of OCT-4 was detectable in both nucleus and the cytoplasm of almost all breast tumors, but it was detectable at much lower level in normal breast tissues. OCT-4 expression was noted on poorly differentiated papillary carcinoma of thyroid compared to normal follicles of thyroid gland adjacent to the tumor.

Conclusion: Breast carcinomas and papillary carcinomas of thyroid express elevated levels of embryonic stem cell gene OCT-4, suggesting that these tumors may contain cells indicative of embryonic-like stem cells. Identification of cancer stem cells in different malignant tumors may be useful for prognostic evaluation and administration of a new treatment which target this sub-population of tumor cells.

Keywords

cancer stem cells Breast Cancer seminoma oct-4

© 2009, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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