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Prevalence of Anti‐EBV Antibodies in Adult Patients with Nasopharyngeal Carcinoma During 2003‐2007 In Isfahan, Iran

AUTHORS

M Mokhtari 1 , M Hashemi Jazi 2 , Amir Hosein Ddavarpanah Jaz 3 , *

1 Associate Professor of Pathology, Department of pathology, Isfahan University of Medical Sciences (IUMS), Iran

2 Assistant Professor of ENT Department of ENT, Isfahan University of Medical Sciences (IUMS), Iran

3 Talented Development Office, Isfahan University of Medical Science (IUMS), Iran

How to Cite: Mokhtari M, Hashemi Jazi M, Ddavarpanah Jaz A H . Prevalence of Anti‐EBV Antibodies in Adult Patients with Nasopharyngeal Carcinoma During 2003‐2007 In Isfahan, Iran, Int J Cancer Manag. 2008 ; 1(4):e80603.

ARTICLE INFORMATION

International Journal of Cancer Management: 1 (4); e80603
Published Online: December 31, 2008
Article Type: Research Article
Received: December 31, 2008
Accepted: December 31, 2008

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Abstract

Background: Nasopharyngeal carcinoma (NPC) is a nonlymphomatous squamous cell carcinoma (SCC) that occurs in the epithelial lining of the nasopharynx. Viral, geographic, and ethnic factors are responsible for its multifactorial futures. Previous studies have showed the role of Epstein-Barr virus (EBV) in the pathogenesis of NPC but no study has been conducted on the Iranian population to assess the etiology of NPC and to investigate the role of EBV in carcinogenesis of nasopharyngeal carcinoma.

Methods: We collected 87 paraffin wax embedded blocks of NPC (n=34) and Laryngeal SCC patients (n=53) operated in Isfahan Hospitals during 2003-2007 from the archives of the department of pathology and then sera of patients were provided. We measured the titers of early antigen (anti-EA) and Epstein-Barr virus nuclear antigen (anti-EBNA) antibodies by means of ELISA method in sera of patients.

Results: Our data showed a significant association between elevated titer of these antibodies and the presence of NPC (P value =0.016 for anti-EBNA and 0.001 for anti-EA antibodies); however, we did not find such a relationship about Laryngeal SCC.

Conclusion: The prevalence of EBV infection in patient with NPC is significantly higher than the control group. Further studies should investigate the value of serum markers of EBV infection in the follow up or early diagnosis of NPC in high risk patients.

Keywords

nasopharyngeal carcinoma Epstein-Barr virus squamous cell carcinoma

© 2008, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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