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Association between Genetic Polymorphism of Methylenetetrahydrofolate Reductase with Non Familial Colorectal Cancer in Iranian Population

AUTHORS

Mahdi Montazer Haghighi 1 , * , R Radpour 2 , M Vahedi 3 , SR Mohebbi 3 , F Khatami 3 , F Derakhshan 3 , H Atarian 4 , MR Zali 3

1 Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University (MC), Taleghani Hospital; Department of Genetics, Faculty of Science, Islamic Azad University, East of Tehran branch, Iran

2 Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University (MC), Taleghani Hospital, Tehran, Iran; Laborenatal Medicine, Department of Obstetrics Gynecology and Oncology, University oatory for Prf Basel, Switzerland

3 Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University (MC), Taleghani Hospital, Iran

4 Department of Oncology, , Shahid Beheshti University (MC), Taleghani Hospital, Iran

How to Cite: Montazer Haghighi M, Radpour R, Vahedi M, Mohebbi S, Khatami F, et al. Association between Genetic Polymorphism of Methylenetetrahydrofolate Reductase with Non Familial Colorectal Cancer in Iranian Population, Int J Cancer Manag. 2008 ; 1(3):e80489.

ARTICLE INFORMATION

International Journal of Cancer Management: 1 (3); e80489
Published Online: September 30, 2008
Article Type: Research Article
Received: September 30, 2008
Accepted: September 30, 2008

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Abstract

Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme regulating folate metabolism, which affects DNA methylation and synthesis. One of the most important polymorphisms identified in the MTHFR gene is C677T. MTHFR activity is lowered in individuals with 677TT genotype. Using pyrosequencing, we analyzed the MTHFR genotypes in 118 colorectal cancer patients and 189 normal matched controls. Whereas the CC, CT and TT genotypes of MTHFR among the colorectal cancer patients were 51.7%, 28.0 % and 20.3% respectively, we were able to find 47.1% of 677CC, 27.0% of 677CT and 25.9% of 677TT in normal controls. An inverse association was observed between the risk of colorectal cancer and TT genotype with the odds ratios (OR) of 1, 0.94 and 0.71 for CC, CT, and TT genotypes, respectively. This association was similar in both sexes, but in patients with high levels of folate intake. Our study corroborates previous findings of an inverse association between MTHFR 677TT genotype and colorectal cancer, especially at high levels of folate.

Keywords

non familial colorectal cancer methylenetetrahydrofolate reductase pyrosequencing polymorphism

© 2008, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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