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Obesity as an Important Risk Factor for Certain Types of Cancer

AUTHORS

Sayed Hossain Davoodi 1 , Talieh Malek-Shahabi 2 , Ali Malekshahi-Moghadam 3 , Roghieh Shahbazi 1 , Saeideh Esmaeili 4 , *

1 Dept. of Clinical Nutrition and Dietetics, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences, Food Science and Technology, Shahid Beheshti University of Medical Sciences,Tehran, Iran

2 Dept. of Molecular genetics, Shahid Beheshti University, Tehran, Iran

3 Faculty of Veterinary Medicine, Tehran University , Tehran, Iran

4 Dept. of Food Technology Research, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran

How to Cite: Davoodi S H, Malek-Shahabi T, Malekshahi-Moghadam A, Shahbazi R, Esmaeili S. Obesity as an Important Risk Factor for Certain Types of Cancer, Int J Cancer Manag. 2013 ; 6(4):e80466.

ARTICLE INFORMATION

International Journal of Cancer Management: 6 (4); e80466
Published Online: December 30, 2013
Article Type: Review Article
Received: August 19, 2013
Accepted: September 28, 2013

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Abstract

Cancer could be described as the uncontrolled and unrestricted growth of malignant cells in any place of the body. It is a multifactorial disease which either heredity or environmental factors (such as nutrition, physical inactivity, alcohol, obesity, exposure to sun, environmental pollutants, infections) chip in incidence of cancer. In recent years, several researchers have focused on obesity as a potent cancer risk factor. Scientificevidences have suggested that obesity has associated with increased risk for a plenty of different types of cancer. The evidences are the most consistent for endometrial cancer, breast cancer between the postmenopausal women, and renal cell cancer. More contradictoryresults have reported about the colorectal, prostate, and pancreatic cancer. Although numerous studies have done according to the obesity and cancer relation or joint, but the molecular mechanisms in which obesity could increase the risks of cancer, have been poorly understood.

Keywords

Neoplasms Obesity Adipocyte Adipokines Adiponectin

© 2013, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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