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Could Cancer Initiate From Bone Marrow Progenitors?

AUTHORS

Hmed Ben Nasr 1 , * , Serria Turky Hammami 1 , Khaled Zeghal 1

1 Dept. of Pharmacology, Medicine Faculty, Sfax University, Rue Magida Boulila, Sfax, Tunisia

How to Cite: Ben Nasr H , Turky Hammami S, Zeghal K. Could Cancer Initiate From Bone Marrow Progenitors?, Int J Cancer Manag. 2013 ; 6(2):e80411.

ARTICLE INFORMATION

International Journal of Cancer Management: 6 (2); e80411
Published Online: June 30, 2013
Article Type: Review Article
Received: February 11, 2013
Accepted: April 09, 2013

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Abstract

Background: Defining cancer stem cells and their origins is of much controversy, and constitutes a challenged knockout for cell targeting- anticancer drugs. Herein, we put forward a hypothetic model for cancer stem cells initiation from bone marrow stem cells. These later, will differentiate into an ancestral progenitor that activates a memorial program – the black box cassette- that is responsible of abnormal neo-organogenesis in the form of tumors and metastases. To approve this model, we assume that characterizing and investigating the most primitive forms of the bone marrow progenitors is required; both inside their niche and in circulation of cancer patients.

Keywords

Bone marrow Progenitors Neoplasm Origin

© 2013, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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