International Journal of Cancer Management

Published by: Kowsar

Investigation of the Association of HOTAIR Single Nucleotide Polymorphisms and Risk of Breast Cancer in an Iranian Population

Hamid Reza Khorshidi 1 , Mohammad Taheri 2 , Rezvan Noroozi 2 , Mohammad Soudyab 3 , Arezou Sayad 2 , * and Soudeh Ghafouri-Fard 2 , *
Authors Information
1 Department of Surgery, Hamadan University of Medical sciences, Hamadan, Iran
2 Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3 Department of Medical Genetics, Mashhad University of Medical Sciences, Mashhad, Iran
Corresponding Authors:
Article information
  • International Journal of Cancer Management: May 2017, 10 (5); e7498
  • Published Online: May 3, 2017
  • Article Type: Research Article
  • Received: June 11, 2016
  • Revised: July 13, 2016
  • Accepted: April 29, 2017
  • DOI: 10.5812/ijcm.7498

To Cite: Khorshidi H R, Taheri M, Noroozi R, Soudyab M, Sayad A, et al. Investigation of the Association of HOTAIR Single Nucleotide Polymorphisms and Risk of Breast Cancer in an Iranian Population, Int J Cancer Manag. 2017 ; 10(5):e7498. doi: 10.5812/ijcm.7498.

Copyright © 2017, International Journal of Cancer Management. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Soudyab M, Iranpour M, Ghafouri-Fard S. The Role of Long Non-Coding RNAs in Breast Cancer. Arch Iran Med. 2016; 19(7): 508-17[PubMed]
  • 2. Haghighat S, Akbari ME, Yavari P, Javanbakht M, Ghaffari S. Cost-Effectiveness of Three Rounds of Mammography Breast Cancer Screening in Iranian Women. Iran J Cancer Prev. 2016; 9(1): 5443[DOI][PubMed]
  • 3. Iranpour M, Soudyab M, Geranpayeh L, Mirfakhraie R, Azargashb E, Movafagh A, et al. Expression analysis of four long noncoding RNAs in breast cancer. Tumour Biol. 2016; 37(3): 2933-40[DOI][PubMed]
  • 4. Bayram S, Sumbul AT, Batmaci CY, Genc A. Effect of HOTAIR rs920778 polymorphism on breast cancer susceptibility and clinicopathologic features in a Turkish population. Tumour Biol. 2015; 36(5): 3863-70[DOI][PubMed]
  • 5. Tabarestani S, Ghafouri-Fard S. Cancer stem cells and response to therapy. Asian Pac J Cancer Prev. 2012; 13(12): 5951-8[PubMed]
  • 6. Rinn JL, Kertesz M, Wang JK, Squazzo SL, Xu X, Brugmann SA, et al. Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell. 2007; 129(7): 1311-23[DOI][PubMed]
  • 7. Gupta RA, Shah N, Wang KC, Kim J, Horlings HM, Wong DJ, et al. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature. 2010; 464(7291): 1071-6[DOI][PubMed]
  • 8. Tsai MC, Manor O, Wan Y, Mosammaparast N, Wang JK, Lan F, et al. Long noncoding RNA as modular scaffold of histone modification complexes. Science. 2010; 329(5992): 689-93[DOI][PubMed]
  • 9. Axelsdottir E. The rna hotair promotes chromatin alteration in cancer. Undergraguate Res J. 2014;
  • 10. Nikpayam E, Tasharrofi B, Sarrafzadeh S, Ghafouri-Fard S. The Role of Long Non-Coding RNAs in Ovarian Cancer. Iran Biomed J. 2017; 21(1): 3-15[DOI][PubMed]
  • 11. Qiu H, Liu Q, Li J, Wang X, Wang Y, Yuan Z, et al. Analysis of the association of HOTAIR single nucleotide polymorphism (rs920778) and risk of cervical cancer. APMIS. 2016; 124(7): 567-73[DOI][PubMed]
  • 12. Zhang X, Zhou L, Fu G, Sun F, Shi J, Wei J, et al. The identification of an ESCC susceptibility SNP rs920778 that regulates the expression of lncRNA HOTAIR via a novel intronic enhancer. Carcinogenesis. 2014; 35(9): 2062-7[DOI][PubMed]
  • 13. Bayram S, Sumbul AT, Dadas E. A functional HOTAIR rs12826786 C>T polymorphism is associated with breast cancer susceptibility and poor clinicopathological characteristics in a Turkish population: a hospital-based case-control study. Tumour Biol. 2016; 37(4): 5577-84[DOI][PubMed]
  • 14. Yan R, Cao J, Song C, Chen Y, Wu Z, Wang K, et al. Polymorphisms in lncRNA HOTAIR and susceptibility to breast cancer in a Chinese population. Cancer Epidemiol. 2015; 39(6): 978-85[DOI][PubMed]
  • 15. Zhang H, Cai K, Wang J, Wang X, Cheng K, Shi F, et al. MiR-7, inhibited indirectly by lincRNA HOTAIR, directly inhibits SETDB1 and reverses the EMT of breast cancer stem cells by downregulating the STAT3 pathway. Stem Cells. 2014; 32(11): 2858-68[DOI][PubMed]
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