International Journal of Cancer Management

Published by: Kowsar

Genetic Variations in Leptin and Leptin Receptor and Susceptibility to Colorectal Cancer and Obesity

Touraj Mahmoudi 1 , * , Hamid Farahani 2 , Hossein Nobakht 3 , Reza Dabiri 3 and Mohammad Reza Zali 1
Authors Information
1 Department of Cancer, Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
2 Department of Physiology, School of Medicine, Qom University of Medical Sciences, Qom, IR Iran
3 Internal Medicine Department, Semnan University of Medical Sciences, Semnan, IR Iran
Article information
  • Iranian Journal of Cancer Prevention: June 2016, 9 (3); e7013
  • Published Online: June 13, 2016
  • Article Type: Research Article
  • Received: February 11, 2015
  • Accepted: April 15, 2016
  • DOI: 10.17795/ijcp-7013

To Cite: Mahmoudi T, Farahani H, Nobakht H, Dabiri R, Zali M R. Genetic Variations in Leptin and Leptin Receptor and Susceptibility to Colorectal Cancer and Obesity, Int J Cancer Manag. 2016 ; 9(3):e7013. doi: 10.17795/ijcp-7013.

Abstract
Copyright © 2016, Iranian Journal of Cancer Prevention. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
Acknowledgements
Footnotes
References
  • 1. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010; 127(12): 2893-917[DOI][PubMed]
  • 2. Caan BJ, Coates AO, Slattery ML, Potter JD, Quesenberry CJ, Edwards SM. Body size and the risk of colon cancer in a large case-control study. Int J Obes Relat Metab Disord. 1998; 22(2): 178-84[PubMed]
  • 3. Schoen RE, Tangen CM, Kuller LH, Burke GL, Cushman M, Tracy RP, et al. Increased blood glucose and insulin, body size, and incident colorectal cancer. J Natl Cancer Inst. 1999; 91(13): 1147-54[PubMed]
  • 4. Joshi RK, Lee SA. Obesity related adipokines and colorectal cancer: a review and meta-analysis. Asian Pac J Cancer Prev. 2014; 15(1): 397-405[PubMed]
  • 5. Trevisan M, Liu J, Muti P, Misciagna G, Menotti A, Fucci F, et al. Markers of insulin resistance and colorectal cancer mortality. Cancer Epidemiol Biomarkers Prev. 2001; 10(9): 937-41[PubMed]
  • 6. Falorni A, Bini V, Molinari D, Papi F, Celi F, Di Stefano G, et al. Leptin serum levels in normal weight and obese children and adolescents: relationship with age, sex, pubertal development, body mass index and insulin. Int J Obes Relat Metab Disord. 1997; 21(10): 881-90[PubMed]
  • 7. Zimmet PZ, Collins VR, de Courten MP, Hodge AM, Collier GR, Dowse GK, et al. Is there a relationship between leptin and insulin sensitivity independent of obesity? A population-based study in the Indian Ocean nation of Mauritius. Mauritius NCD Study Group. Int J Obes Relat Metab Disord. 1998; 22(2): 171-7[PubMed]
  • 8. Ahima RS, Flier JS. Leptin. Annu Rev Physiol. 2000; 62: 413-37[DOI][PubMed]
  • 9. Ogunwobi OO, Beales IL. The anti-apoptotic and growth stimulatory actions of leptin in human colon cancer cells involves activation of JNK mitogen activated protein kinase, JAK2 and PI3 kinase/Akt. Int J Colorectal Dis. 2007; 22(4): 401-9[DOI][PubMed]
  • 10. Hardwick JC, Van Den Brink GR, Offerhaus GJ, Van Deventer SJ, Peppelenbosch MP. Leptin is a growth factor for colonic epithelial cells. Gastroenterology. 2001; 121(1): 79-90[PubMed]
  • 11. Stattin P, Palmqvist R, Soderberg S, Biessy C, Ardnor B, Hallmans G, et al. Plasma leptin and colorectal cancer risk: a prospective study in Northern Sweden. Oncol Rep. 2003; 10(6): 2015-21[PubMed]
  • 12. Tamakoshi K, Toyoshima H, Wakai K, Kojima M, Suzuki K, Watanabe Y, et al. Leptin is associated with an increased female colorectal cancer risk: a nested case-control study in Japan. Oncology. 2005; 68(4-6): 454-61[DOI][PubMed]
  • 13. Stocks T, Lukanova A, Johansson M, Rinaldi S, Palmqvist R, Hallmans G, et al. Components of the metabolic syndrome and colorectal cancer risk; a prospective study. Int J Obes (Lond). 2008; 32(2): 304-14[DOI][PubMed]
  • 14. Slattery ML, Wolff RK, Herrick J, Caan BJ, Potter JD. Leptin and leptin receptor genotypes and colon cancer: gene-gene and gene-lifestyle interactions. Int J Cancer. 2008; 122(7): 1611-7[DOI][PubMed]
  • 15. Vasku A, Vokurka J, Bienertova-Vasku J. Obesity-related genes variability in Czech patients with sporadic colorectal cancer: preliminary results. Int J Colorectal Dis. 2009; 24(3): 289-94[DOI][PubMed]
  • 16. Pechlivanis S, Bermejo JL, Pardini B, Naccarati A, Vodickova L, Novotny J, et al. Genetic variation in adipokine genes and risk of colorectal cancer. Eur J Endocrinol. 2009; 160(6): 933-40[DOI][PubMed]
  • 17. Partida-Perez M, de la Luz Ayala-Madrigal M, Peregrina-Sandoval J, Macias-Gomez N, Moreno-Ortiz J, Leal-Ugarte E, et al. Association of LEP and ADIPOQ common variants with colorectal cancer in Mexican patients. Cancer Biomark. 2010; 7(3): 117-21[DOI][PubMed]
  • 18. He J, Xu G. LEP gene variant is associated with prostate cancer but not with colorectal cancer. Tumour Biol. 2013; 34(5): 3131-6[DOI][PubMed]
  • 19. Liu L, Zhong R, Wei S, Xiang H, Chen J, Xie D, et al. The leptin gene family and colorectal cancer: interaction with smoking behavior and family history of cancer. PLoS One. 2013; 8(4)[DOI][PubMed]
  • 20. Yiannakouris N, Yannakoulia M, Melistas L, Chan JL, Klimis-Zacas D, Mantzoros CS. The Q223R polymorphism of the leptin receptor gene is significantly associated with obesity and predicts a small percentage of body weight and body composition variability. J Clin Endocrinol Metab. 2001; 86(9): 4434-9[DOI][PubMed]
  • 21. Quinton ND, Lee AJ, Ross RJ, Eastell R, Blakemore AI. A single nucleotide polymorphism (SNP) in the leptin receptor is associated with BMI, fat mass and leptin levels in postmenopausal Caucasian women. Hum Genet. 2001; 108(3): 233-6[PubMed]
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