International Journal of Cancer Management

Published by: Kowsar

No Detection of Streptococcus gallolyticus and Helicobacter pylori in Colorectal Cancer Tissue Samples in Shiraz, Iran

Shahab Mahmoudvand 1 , Khosrow Zamani 1 , Akbar Safaei 2 , Reza Khashei 1 , Mohammad Motamedifar 3 , Zohre Azizi 1 and Jamal Sarvari 1 , 4 , *
Authors Information
1 Department of Bacteriology & Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
2 Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
3 Shiraz HIV/AIDS Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran
4 Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Article information
  • Iranian Journal of Cancer Prevention: January 2017, 10 (1); e6337
  • Published Online: January 23, 2017
  • Article Type: Research Article
  • Received: April 11, 2016
  • Revised: July 17, 2016
  • Accepted: January 3, 2017
  • DOI: 10.17795/ijcp-6337

To Cite: Mahmoudvand S, Zamani K, Safaei A, Khashei R, Motamedifar M, et al. No Detection of Streptococcus gallolyticus and Helicobacter pylori in Colorectal Cancer Tissue Samples in Shiraz, Iran, Int J Cancer Manag. 2017 ; 10(1):e6337. doi: 10.17795/ijcp-6337.

Copyright © 2017, Iranian Journal of Cancer Prevention. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Antonic V, Stojadinovic A, Kester KE, Weina PJ, Brucher BL, Protic M, et al. Significance of infectious agents in colorectal cancer development. J Cancer. 2013; 4(3): 227-40[DOI][PubMed]
  • 2. Salehi Z, Miri M, Aminian K, Mansour-Ghanaei F. Helicobacter pylori infection and colorectal cancer in Guilan province of Iran. Ann Biol Res. 2011; 2(1): 32-9
  • 3. Sadjadi A, Malekzadeh R, Derakhshan MH, Sepehr A, Nouraie M, Sotoudeh M, et al. Cancer occurrence in Ardabil: results of a population-based cancer registry from Iran. Int J Cancer. 2003; 107(1): 113-8[DOI][PubMed]
  • 4. Azadeh S, Moghimi-Dehkordi B, Fatem SR, Pourhoseingholi MA, Ghiasi S, Zali MR. Colorectal cancer in Iran: an epidemiological study. Asian Pac J Cancer Prev. 2008; 9(1): 123-6[PubMed]
  • 5. Cummins J, Tangney M. Bacteria and tumours: causative agents or opportunistic inhabitants? Infect Agent Cancer. 2013; 8(1): 11[DOI][PubMed]
  • 6. Sarvari J, Mojtahedi Z, Kuramitsu Y, Fattahi MR, Ghaderi A, Nakamura K, et al. Comparative Proteomics of Sera From HCC Patients With Different Origins. Hepat Mon. 2014; 14(1): 13103[DOI][PubMed]
  • 7. Collins D, Hogan AM, Winter DC. Microbial and viral pathogens in colorectal cancer. Lancet Oncol. 2011; 12(5): 504-12[DOI][PubMed]
  • 8. Mantzaris GJ. Helicobacter pylori and colorectal cancer: Is there any link? Ann Gastroenterol. 2004; 17(1): 17-8
  • 9. Nishizawa T, Suzuki H. Gastric Carcinogenesis and Underlying Molecular Mechanisms: Helicobacter pylori and Novel Targeted Therapy. Biomed Res Int. 2015; 2015: 794378[DOI][PubMed]
  • 10. Atkin WS, Morson BC, Cuzick J. Long-term risk of colorectal cancer after excision of rectosigmoid adenomas. N Engl J Med. 1992; 326(10): 658-62[DOI][PubMed]
  • 11. Hosseini E, Poursina F, de Wiele TV, Safaei HG, Adibi P. Helicobacter pylori in Iran: A systematic review on the association of genotypes and gastroduodenal diseases. J Res Med Sci. 2012; 17(3): 280-92[PubMed]
  • 12. Bazargani A, Khoramrooz SS, Kamali-Sarvestani E, Taghavi SA, Saberifiroozi M. Association between peroxisome proliferator-activated receptor-gamma gene polymorphism (Pro12Ala) and Helicobacter pylori infection in gastric carcinogenesis. Scand J Gastroenterol. 2010; 45(10): 1162-7[DOI][PubMed]
  • 13. Hong SN, Lee SM, Kim JH, Lee TY, Kim JH, Choe WH, et al. Helicobacter pylori infection increases the risk of colorectal adenomas: cross-sectional study and meta-analysis. Dig Dis Sci. 2012; 57(8): 2184-94[DOI][PubMed]
  • 14. Uemura N, Okamoto S, Yamamoto S, Matsumura N, Yamaguchi S, Yamakido M, et al. Helicobacter pylori infection and the development of gastric cancer. N Engl J Med. 2001; 345(11): 784-9[DOI][PubMed]
  • 15. Waisberg JMC, Pimenta J. Infectious endocarditis from Streptococcus bovis associated with colonic carcinoma: Case report and literature review. Arq Gastroenterol. 2002; 39(3): 177-80[DOI]
  • 16. Alexander DD, Cushing CA, Lowe KA, Sceurman B, Roberts MA. Meta-analysis of animal fat or animal protein intake and colorectal cancer. Am J Clin Nutr. 2009; 89(5): 1402-9[DOI][PubMed]
  • 17. Abdulamir AS, Hafidh RR, Bakar FA. Molecular detection, quantification, and isolation of Streptococcus gallolyticus bacteria colonizing colorectal tumors: inflammation-driven potential of carcinogenesis via IL-1, COX-2, and IL-8. Mol Cancer. 2010; 9: 249[DOI][PubMed]
  • 18. Mahmoudvand S, Safaei A, Erfani N, Sarvari J. Presence of Human Papillomavirus DNA in Colorectal Cancer Tissues in Shiraz, Southwest Iran. Asian Pac J Cancer Prev. 2015; 16(17): 7883-7[DOI][PubMed]
  • 19. Potter MA, Cunliffe NA, Smith M, Miles RS, Flapan AD, Dunlop MG. A prospective controlled study of the association of Streptococcus bovis with colorectal carcinoma. J Clin Pathol. 1998; 51(6): 473-4[PubMed]
  • 20. Norfleet RG, Mitchell PD. Streptococcus bovis does not selectively colonize colorectal cancer and polyps. J Clin Gastroenterol. 1993; 17(1): 25-8[DOI][PubMed]
  • 21. Darjee R, Gibb AP. Serological investigation into the association between Streptococcus bovis and colonic cancer. J Clin Pathol. 1993; 46(12): 1116-9[DOI][PubMed]
  • 22. Al-Jashamy K, Murad A, Zeehaida M, Rohaini M, Hasnan J. Prevalence of colorectal cancer associated with Streptococcus bovis among inflammatory bowel and chronic gastrointestinal tract disease patients. Asian Pac J Cancer Prev. 2010; 11(6): 1765-8[PubMed]
  • 23. Abdulamir AS, Hafidh RR, Mahdi LK, Al-jeboori T, Abubaker F. Investigation into the controversial association of Streptococcus gallolyticus with colorectal cancer and adenoma. BMC Cancer. 2009; 9: 403[DOI][PubMed]
  • 24. Bulajic M, Stimec B, Jesenofsky R, Kecmanovic D, Ceranic M, Kostic N, et al. Helicobacter pylori in colorectal carcinoma tissue. Cancer Epidemiol Biomarkers Prev. 2007; 16(3): 631-3[DOI][PubMed]
  • 25. Sameer AS, Abdullah S, Nissar S, Rasool R, Mudassir Baba S, Siddiqi MA. Helicobacter pylori in colorectal neoplasms of Kashmiri patients: What is the prevalence? Clin Cancer Investig J. 2012; 1(1): 23-5[DOI]
  • 26. Grahn N, Hmani-Aifa M, Fransen K, Soderkvist P, Monstein HJ. Molecular identification of Helicobacter DNA present in human colorectal adenocarcinomas by 16S rDNA PCR amplification and pyrosequencing analysis. J Med Microbiol. 2005; 54: 1031-5[DOI][PubMed]
  • 27. Fireman Z, Trost L, Kopelman Y, Segal A, Sternberg A. Helicobacter pylori: seroprevalence and colorectal cancer. Isr Med Assoc J. 2000; 2(1): 6-9[PubMed]
  • 28. Siddheshwar RK, Muhammad KB, Gray JC, Kelly SB. Seroprevalence of Helicobacter pylori in patients with colorectal polyps and colorectal carcinoma. Am J Gastroenterol. 2001; 96(1): 84-8[DOI][PubMed]
  • 29. Zhang Y, Hoffmeister M, Weck MN, Chang-Claude J, Brenner H. Helicobacter pylori infection and colorectal cancer risk: evidence from a large population-based case-control study in Germany. Am J Epidemiol. 2012; 175(5): 441-50[DOI][PubMed]
  • 30. Zumkeller N, Brenner H, Chang-Claude J, Hoffmeister M, Nieters A, Rothenbacher D. Helicobacter pylori infection, interleukin-1 gene polymorphisms and the risk of colorectal cancer: evidence from a case-control study in Germany. Eur J Cancer. 2007; 43(8): 1283-9[DOI][PubMed]
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