International Journal of Cancer Management

Published by: Kowsar

Treatment Compliance and Outcome in Geriatric Patients with Locally Advanced Non-Small Cell Lung Cancer: Experience from India

Sushmita Pathy 1 , * , Soumyajit Roy 1 , Prabhat Singh Malik 2 , Bidhu Kalyan Mohanti 1 and Vinod Raina 2
Authors Information
1 Departments of Radiation Oncology, Dr. BRA Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India
2 Departments of Medical Oncology, Dr. BRA Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India
Article information
  • Iranian Journal of Cancer Prevention: December 2016, 9 (6); e5481
  • Published Online: December 7, 2016
  • Article Type: Research Article
  • Received: January 25, 2016
  • Revised: April 1, 2016
  • Accepted: December 3, 2016
  • DOI: 10.17795/ijcp-5481

To Cite: Pathy S, Roy S, Malik P S, Mohanti B K, Raina V. Treatment Compliance and Outcome in Geriatric Patients with Locally Advanced Non-Small Cell Lung Cancer: Experience from India, Int J Cancer Manag. 2016 ; 9(6):e5481. doi: 10.17795/ijcp-5481.

Copyright © 2016, Iranian Journal of Cancer Prevention. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Introduction and Background
2. Methods
3. Results
4. Discussion
  • 1. Smith BD, Smith GL, Hurria A, Hortobagyi GN, Buchholz TA. Future of cancer incidence in the United States: burdens upon an aging, changing nation. J Clin Oncol. 2009; 27(17): 2758-65[DOI][PubMed]
  • 2. Owonikoko TK, Ragin CC, Belani CP, Oton AB, Gooding WE, Taioli E, et al. Lung cancer in elderly patients: an analysis of the surveillance, epidemiology, and end results database. J Clin Oncol. 2007; 25(35): 5570-7[DOI][PubMed]
  • 3. Mallath MK, Taylor DG, Badwe RA, Rath GK, Shanta V, Pramesh CS, et al. The growing burden of cancer in India: epidemiology and social context. Lancet Oncol. 2014; 15(6)-12[DOI][PubMed]
  • 4. Singh N, Aggarwal AN, Gupta D, Behera D, Jindal SK. Unchanging clinico-epidemiological profile of lung cancer in north India over three decades. Cancer Epidemiol. 2010; 34(1): 101-4[DOI][PubMed]
  • 5. Malik PS, Sharma MC, Mohanti BK, Shukla NK, Deo S, Mohan A, et al. Clinico-pathological profile of lung cancer at AIIMS: a changing paradigm in India. Asian Pac J Cancer Prev. 2013; 14(1): 489-94[PubMed]
  • 6. Auperin A, Le Pechoux C, Rolland E, Curran WJ, Furuse K, Fournel P. Meta-analysis of concomitant versus sequential radiochemotherapy in locally advanced non-small-cell lung cancer. J Clin Oncol. 2010; 28(13): 2181-90
  • 7. Curran WJ, Paulus R, Langer CJ, Komaki R, Lee JS, Hauser S, et al. Sequential vs. concurrent chemoradiation for stage III non-small cell lung cancer: randomized phase III trial RTOG 9410. J Natl Cancer Inst. 2011; 103(19): 1452-60[DOI][PubMed]
  • 8. Penson RT, Daniels KJ, Lynch TJ. Too old to care? Oncologist. 2004; 9(3): 343-52[PubMed]
  • 9. Goodwin JS, Hunt WC, Humble CG, Key CR, Samet JM. Cancer treatment protocols. Who gets chosen? Arch Intern Med. 1988; 148(10): 2258-60[PubMed]
  • 10. Hutchins LF, Unger JM, Crowley JJ, Coltman CJ, Albain KS. Underrepresentation of patients 65 years of age or older in cancer-treatment trials. N Engl J Med. 1999; 341(27): 2061-7[DOI][PubMed]
  • 11. Gridelli C, Perrone F, Gallo C, Cigolari S, Rossi A, Piantedosi F, et al. Chemotherapy for elderly patients with advanced non-small-cell lung cancer: the Multicenter Italian Lung Cancer in the Elderly Study (MILES) phase III randomized trial. J Natl Cancer Inst. 2003; 95(5): 362-72[PubMed]
  • 12. Sharma A, Madan R, Kumar R, Sagar P, Kamal VK, Thakar A, et al. Compliance to therapy-elderly head and neck carcinoma patients. Can Geriatr J. 2014; 17(3): 83-7[DOI][PubMed]
  • 13. Pepe C, Hasan B, Winton TL, Seymour L, Graham B, Livingston RB, et al. Adjuvant vinorelbine and cisplatin in elderly patients: National Cancer Institute of Canada and Intergroup Study JBR.10. J Clin Oncol. 2007; 25(12): 1553-61[DOI][PubMed]
  • 14. Hsu CL, Chen JH, Chen KY, Shih JY, Yang JC, Yu CJ, et al. Advanced non-small cell lung cancer in the elderly: the impact of age and comorbidities on treatment modalities and patient prognosis. J Geriatr Oncol. 2015; 6(1): 38-45[DOI][PubMed]
  • 15. Mohan A, Singh P, Kumar S, Mohan C, Pathak AK, Pandey RM, et al. Effect of change in symptoms, respiratory status, nutritional profile and quality of life on response to treatment for advanced non-small cell lung cancer. Asian Pac J Cancer Prev. 2008; 9(4): 557-62[PubMed]
  • 16. Blanchon F, Grivaux M, Asselain B, Lebas FX, Orlando JP, Piquet J, et al. 4-year mortality in patients with non-small-cell lung cancer: development and validation of a prognostic index. Lancet Oncol. 2006; 7(10): 829-36[DOI][PubMed]
  • 17. Werner-Wasik M, Scott C, Cox JD, Sause WT, Byhardt RW, Asbell S, et al. Recursive partitioning analysis of 1999 Radiation Therapy Oncology Group (RTOG) patients with locally-advanced non-small-cell lung cancer (LA-NSCLC): identification of five groups with different survival. Int J Radiat Oncol Biol Phys. 2000; 48(5): 1475-82[PubMed]
  • 18. Movsas B, Scott C, Sause W, Byhardt R, Komaki R, Cox J, et al. The benefit of treatment intensification is age and histology-dependent in patients with locally advanced non-small cell lung cancer (NSCLC): a quality-adjusted survival analysis of radiation therapy oncology group (RTOG) chemoradiation studies. Int J Radiat Oncol Biol Phys. 1999; 45(5): 1143-9[PubMed]
  • 19. Rocha Lima CM, Herndon J2, Kosty M, Clamon G, Green MR. Therapy choices among older patients with lung carcinoma: an evaluation of two trials of the Cancer and Leukemia Group B. Cancer. 2002; 94(1): 181-7[PubMed]
  • 20. Schild SE, Stella PJ, Geyer SM, Bonner JA, McGinnis WL, Mailliard JA, et al. The outcome of combined-modality therapy for stage III non-small-cell lung cancer in the elderly. J Clin Oncol. 2003; 21(17): 3201-6[DOI][PubMed]
  • 21. Peake MD, Thompson S, Lowe D, Pearson MG, Participating C. Ageism in the management of lung cancer. Age Ageing. 2003; 32(2): 171-7[PubMed]
  • 22. de Rijke JM, Schouten LJ, ten Velde GP, Wanders SL, Bollen EC, Lalisang RI, et al. Influence of age, comorbidity and performance status on the choice of treatment for patients with non-small cell lung cancer; results of a population-based study. Lung Cancer. 2004; 46(2): 233-45[DOI][PubMed]
  • 23. Extermann M, Aapro M, Bernabei R, Cohen HJ, Droz JP, Lichtman S, et al. Use of comprehensive geriatric assessment in older cancer patients: recommendations from the task force on CGA of the International Society of Geriatric Oncology (SIOG). Crit Rev Oncol Hematol. 2005; 55(3): 241-52[DOI][PubMed]
  • 24. Balducci L. Geriatric oncology. Crit Rev Oncol Hematol. 2003; 46(3): 211-20[DOI]
  • 25. Vigg A, Mantri S, Vigg A, Vigg A. Pattern of lung cancer in elderly. J Assoc Physicians India. 2003; 51: 963-6[PubMed]
  • 26. Ingle GK, Nath A. Geriatric health in India: concerns and solutions. Indian J Community Med. 2008; 33(4): 214-8[DOI][PubMed]
  • 27. Sarkar A, Shahi U. Assessment of cancer care in Indian elderly cancer patients: A single center study. South Asian J Cancer. 2013; 2(4): 202-8[DOI][PubMed]
  • 28. Singh N, Aggarwal AN, Behera D, Jindal SK. Intercycle delays during chemotherapy of non-small cell lung cancer in a health care resource-constrained setting and their effect on overall survival. J Thorac Oncol. 2010; 5(2): 236-9[DOI][PubMed]
  • 29. Dehdashti F, Mintun MA, Lewis JS, Bradley J, Govindan R, Laforest R, et al. In vivo assessment of tumor hypoxia in lung cancer with 60Cu-ATSM. Eur J Nucl Med Mol Imaging. 2003; 30(6): 844-50[DOI][PubMed]
  • 30. Pramesh CS, Badwe RA, Borthakur BB, Chandra M, Raj EH, Kannan T, et al. Delivery of affordable and equitable cancer care in India. Lancet Oncol. 2014; 15(6)-33[DOI][PubMed]
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