International Journal of Cancer Management

Published by: Kowsar

Effects of Two Common Promoter Polymorphisms of Transforming Growth Factor-β1 on Breast Cancer Risks in Ahvaz, West South of Iran

Somayeh Parvizi 1 , Ghorban Mohammadzadeh 2 , * , Maryam Karimi 3 , Mozhgan Noorbehbahani 3 and Alireza Jafary 3
Authors Information
1 Department of Biology, Faculty of Basic Science, Islamic Azad University, Science and Research Branch, Tehran, IR Iran
2 Department of Biochemistry, Faculty of Medicine, Hyperlipidemia Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran
3 Department of Biochemistry, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran
Article information
  • Iranian Journal of Cancer Prevention: February 2016, 9 (1); e5266
  • Published Online: February 24, 2016
  • Article Type: Research Article
  • Received: January 4, 2016
  • Accepted: January 27, 2016
  • DOI: 10.17795/ijcp-5266

To Cite: Parvizi S, Mohammadzadeh G, Karimi M, Noorbehbahani M, Jafary A. Effects of Two Common Promoter Polymorphisms of Transforming Growth Factor-β1 on Breast Cancer Risks in Ahvaz, West South of Iran, Int J Cancer Manag. 2016 ; 9(1):e5266. doi: 10.17795/ijcp-5266.

Copyright © 2016, Iranian Journal of Cancer Prevention. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Imamura T, Hikita A, Inoue Y. The roles of TGF-beta signaling in carcinogenesis and breast cancer metastasis. Breast Cancer. 2012; 19(2): 118-24[DOI][PubMed]
  • 2. Massague J. TGFbeta in Cancer. Cell. 2008; 134(2): 215-30[DOI][PubMed]
  • 3. Padua D, Massague J. Roles of TGFbeta in metastasis. Cell Res. 2009; 19(1): 89-102[DOI][PubMed]
  • 4. Jakowlew SB. Transforming growth factor-beta in cancer and metastasis. Cancer Metastasis Rev. 2006; 25(3): 435-57[DOI][PubMed]
  • 5. Welm AL. TGFbeta primes breast tumor cells for metastasis. Cell. 2008; 133(1): 27-8[DOI][PubMed]
  • 6. Lebrun JJ. The Dual Role of TGFβ in Human Cancer: From Tumor Suppression to Cancer Metastasis. ISRN Molecul Biol. 2012; 7: 1-28[DOI]
  • 7. Shin A, Shu XO, Cai Q, Gao YT, Zheng W. Genetic polymorphisms of the transforming growth factor-beta1 gene and breast cancer risk: a possible dual role at different cancer stages. Cancer Epidemiol Biomarkers Prev. 2005; 14(6): 1567-70[DOI][PubMed]
  • 8. Pardali K, Moustakas A. Actions of TGF-b as tumor suppressor and prometastatic factor in human cancer. Biochim Biophys Acta. 2007; 1775: 21-62
  • 9. Inman GJ. Switching TGFbeta from a tumor suppressor to a tumor promoter. Curr Opin Genet Dev. 2011; 21(1): 93-9[DOI][PubMed]
  • 10. Mishra L, Derynck R, Mishra B. Transforming growth factor-beta signaling in stem cells and cancer. Science. 2005; 310(5745): 68-71[DOI][PubMed]
  • 11. Watabe T, Miyazono K. Roles of TGF-beta family signaling in stem cell renewal and differentiation. Cell Res. 2009; 19(1): 103-15[DOI][PubMed]
  • 12. Buck MB, Knabbe C. TGF-beta signaling in breast cancer. Ann N Y Acad Sci. 2006; 1089: 119-26[DOI][PubMed]
  • 13. Dumont N, Arteaga CL. Targeting the TGFβ signaling network in human neoplasia. Cancer Cell. 2003; 3(6): 531-6[DOI]
  • 14. Pinkas J, Teicher BA. TGF-beta in cancer and as a therapeutic target. Biochem Pharmacol. 2006; 72(5): 523-9[DOI][PubMed]
  • 15. Nagaraj NS, Datta PK. Targeting the transforming growth factor-beta signaling pathway in human cancer. Expert Opin Investig Drugs. 2010; 19(1): 77-91[DOI][PubMed]
  • 16. Connolly EC, Freimuth J, Akhurst RJ. Complexities of TGF-beta targeted cancer therapy. Int J Biol Sci. 2012; 8(7): 964-78[DOI][PubMed]
  • 17. Bhola NE, Balko JM, Dugger TC, Kuba MG, Sanchez V, Sanders M, et al. TGF-beta inhibition enhances chemotherapy action against triple-negative breast cancer. J Clin Invest. 2013; 123(3): 1348-58[DOI][PubMed]
  • 18. Nacif M, Shaker O. Targeting Transforming Growth Factor-β (TGF-β) in Cancer and Non-Neoplastic Diseases. J Cancer Ther. 2014; 5(7): 735-47[DOI]
  • 19. Kelly RJ, Morris JC. Transforming growth factor-beta: a target for cancer therapy. J Immunotoxicol. 2010; 7(1): 15-26[DOI][PubMed]
  • 20. Clezardin P. Therapeutic targets for bone metastases in breast cancer. Breast Cancer Res. 2011; 13(2): 207[DOI][PubMed]
  • 21. Meulmeester E, Ten Dijke P. The dynamic roles of TGF-beta in cancer. J Pathol. 2011; 223(2): 205-18[DOI][PubMed]
  • 22. Zheng W. Genetic polymorphisms in the transforming growth factor-beta signaling pathways and breast cancer risk and survival. Methods Mol Biol. 2009; 472: 265-77[DOI][PubMed]
  • 23. Sheen-Chen SM, Chen HS, Sheen CW, Eng HL, Chen WJ. Serum levels of transforming growth factor beta1 in patients with breast cancer. Arch Surg. 2001; 136(8): 937-40[PubMed]
  • 24. Blobe GC, Schiemann WP, Lodish HF. Role of transforming growth factor beta in human disease. N Engl J Med. 2000; 342(18): 1350-8[DOI][PubMed]
  • 25. Scaglione R, Di Chiara T, Argano C, Duro G, Colomba D, Licata G. The Relationship between the Transforming Growth Factor Beta1 T29c Gene Polymorphism and Left Ventricular Geometry and Function in Hypertensive Subjects. J Hypertens. 2010; 28: 1-7[DOI]
  • 26. Cambien F, Ricard S, Troesch A, Mallet C, Generenaz L, Evans A, et al. Polymorphisms of the transforming growth factor-beta 1 gene in relation to myocardial infarction and blood pressure. The Etude Cas-Temoin de l'Infarctus du Myocarde (ECTIM) Study. Hypertension. 1996; 28(5): 881-7[PubMed]
  • 27. Grainger DJ, Heathcote K, Chiano M, Snieder H, Kemp PR, Metcalfe JC, et al. Genetic control of the circulating concentration of transforming growth factor type beta1. Hum Mol Genet. 1999; 8(1): 93-7[PubMed]
  • 28. Syrris P, Carter ND, Metcalfe JC, Kemp PR, Grainger DJ, Kaski JC, et al. Transforming growth factor-beta1 gene polymorphisms and coronary artery disease. Clin Sci (Lond). 1998; 95(6): 659-67[PubMed]
  • 29. Jin Q, Hemminki K, Grzybowska E, Klaes R, Soderberg M, Zientek H, et al. Polymorphisms and haplotype structures in genes for transforming growth factor beta1 and its receptors in familial and unselected breast cancers. Int J Cancer. 2004; 112(1): 94-9[DOI][PubMed]
  • 30. Cox DG, Penney K, Guo Q, Hankinson SE, Hunter DJ. TGFB1 and TGFBR1 polymorphisms and breast cancer risk in the Nurses' Health Study. BMC Cancer. 2007; 7: 175[DOI][PubMed]
  • 31. Mu L, Katsaros D, Lu L, Preti M, Durando A, Arisio R, et al. TGF-beta1 genotype and phenotype in breast cancer and their associations with IGFs and patient survival. Br J Cancer. 2008; 99(8): 1357-63[DOI][PubMed]
  • 32. Colleran G, McInerney N, Rowan A, Barclay E, Jones AM, Curran C, et al. The TGFBR1*6A/9A polymorphism is not associated with differential risk of breast cancer. Breast Cancer Res Treat. 2010; 119(2): 437-42[DOI][PubMed]
  • 33. Mohammadzadeh G, Ghaffari MA, Bafandeh A, Hosseini SM. Effect of leptin receptor Q223R polymorphism on breast cancer risk. Iran J Basic Med Sci . 2014; 17: 588-94[PubMed]
  • 34. Mohammadzadeh G, Ghaffari MA, Bafandeh A, Hosseini SM. Association of serum soluble leptin receptor and leptin levels with breast cancer. J Res Med Sci. 2014; 19(5): 433-8[PubMed]
  • 35. Vinod C, Jyothy A, Vijay kumar M, Raman R, Nallari P, Venkateshwari A. A Common SNP of IL-10 (-1082A/G) is Associated with Increased Risk of Premenopausal Breast Cancer in South Indian Women. Iran J Cancer Preven. 2015; 8(4)[PubMed]
  • 36. Rejali L, Poopak B, Hasanzad M, Sheikhsofla F, Varnoosfaderani AS, Safari N, Rabieipoor S. Characterizing of Four Common BCR-ABL Kinase Domain Mutations (T315I, Y253H, M351T and E255K) in Iranian Chronic Myelogenous Leukemia Patients with Imatinib Resistance. Iran J Cancer Preven. 2005; 8(3)[PubMed]
  • 37. Kim SJ, Glick A, Sporn MB, Roberts AB. Characterization of the promoter region of the human transforming growth factor-beta 1 gene. J Biol Chem. 1989; 264(1): 402-8[PubMed]
  • 38. Shah R, Hurley CK, Posch PE. A molecular mechanism for the differential regulation of TGF-beta1 expression due to the common SNP -509C-T (c. -1347C > T). Hum Genet. 2006; 120(4): 461-9[DOI][PubMed]
  • 39. Zhang Y, Zhang J, Huang J, Li X, He C, Tian C, et al. Polymorphisms in the transforming growth factor-beta1 gene and the risk of asthma: A meta-analysis. Respirology. 2010; 15(4): 643-50[DOI][PubMed]
  • 40. Huang Y, Hao Y, Li B, Xie J, Qian J, Chao C, et al. Lack of significant association between TGF-beta1-590C/T polymorphism and breast cancer risk: a meta-analysis. Med Oncol. 2011; 28(2): 424-8[DOI][PubMed]
  • 41. Lee HJ, Kim H, Ku SY, Kim SH, Kim JG. Transforming growth factor-beta1 gene polymorphisms in Korean women with endometriosis. Am J Reprod Immunol. 2011; 66(5): 428-34[DOI][PubMed]
  • 42. Wang Y, Chu X, Meng X, Zou F. Association of TGF-beta1 -509C/T polymorphisms with breast cancer risk: evidence from an updated meta-analysis. Tumour Biol. 2014; 35(2): 935-42[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments