International Journal of Cancer Management

Published by: Kowsar

Hypoxia Response Elements Can Cause the Overexpression of the BAX mRNA Under Hypoxic Condition

Ali Ghanbariasad 1 , Mojgan Bandehpour 1 , 2 , 3 and Bahram Kazemi 1 , 2 , 3 , *
Authors Information
1 Department of Biotechnology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
2 Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
3 Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
Article information
  • Iranian Journal of Cancer Prevention: October 2016, 9 (5); e4554
  • Published Online: October 5, 2016
  • Article Type: Research Article
  • Received: October 31, 2015
  • Revised: December 22, 2015
  • Accepted: September 24, 2016
  • DOI: 10.17795/ijcp-4554

To Cite: Ghanbariasad A, Bandehpour M, Kazemi B. Hypoxia Response Elements Can Cause the Overexpression of the BAX mRNA Under Hypoxic Condition, Int J Cancer Manag. 2016 ; 9(5):e4554. doi: 10.17795/ijcp-4554.

Abstract
Copyright © 2016, Iranian Journal of Cancer Prevention. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Methods
3. Results
4. Discussion
Acknowledgements
Footnotes
References
  • 1. Yang WS, Park SO, Yoon AR, Yoo JY, Kim MK, Yun CO, et al. Suicide cancer gene therapy using pore-forming toxin, streptolysin O. Mol Cancer Ther. 2006; 5(6): 1610-9[DOI][PubMed]
  • 2. Huang J, Gao J, Lv X, Li G, Hao D, Yao X, et al. Target gene therapy of glioma: overexpression of BAX gene under the control of both tissue-specific promoter and hypoxia-inducible element. Acta Biochim Biophys Sin (Shanghai). 2010; 42(4): 274-80[PubMed]
  • 3. Lowe SL, Rubinchik S, Honda T, McDonnell TJ, Dong JY, Norris JS. Prostate-specific expression of Bax delivered by an adenoviral vector induces apoptosis in LNCaP prostate cancer cells. Gene Ther. 2001; 8(18): 1363-71[DOI][PubMed]
  • 4. Pirocanac EC, Nassirpour R, Yang M, Wang J, Nardin SR, Gu J, et al. Bax-induction gene therapy of pancreatic cancer. J Surg Res. 2002; 106(2): 346-51[PubMed]
  • 5. Majumdar AS, Hughes DE, Lichtsteiner SP, Wang Z, Lebkowski JS, Vasserot AP. The telomerase reverse transcriptase promoter drives efficacious tumor suicide gene therapy while preventing hepatotoxicity encountered with constitutive promoters. Gene Ther. 2001; 8(7): 568-78[DOI][PubMed]
  • 6. Garg H, Salcedo R, Trinchieri G, Blumenthal R. Improved nonviral cancer suicide gene therapy using survivin promoter-driven mutant Bax. Cancer Gene Ther. 2010; 17(3): 155-63[DOI][PubMed]
  • 7. Lee M. Hypoxia targeting gene expression for breast cancer gene therapy. Adv Drug Deliv Rev. 2009; 61(10): 842-9[DOI][PubMed]
  • 8. Chen PY, Ho YR, Wu MJ, Huang SP, Chen PK, Tai MH, et al. Cytoprotective effects of fisetin against hypoxia-induced cell death in PC12 cells. Food Funct. 2015; 6(1): 287-96[DOI][PubMed]
  • 9. Binley K, Askham Z, Martin L, Spearman H, Day D, Kingsman S, et al. Hypoxia-mediated tumour targeting. Gene Ther. 2003; 10(7): 540-9[DOI][PubMed]
  • 10. Lu CS, Hsieh JL, Lin CY, Tsai HW, Su BH, Shieh GS, et al. Potent antitumor activity of Oct4 and hypoxia dual-regulated oncolytic adenovirus against bladder cancer. Gene Ther. 2015; 22(4): 305-15[DOI][PubMed]
  • 11. Brown JM, Giaccia AJ. The unique physiology of solid tumors: opportunities (and problems) for cancer therapy. Cancer Res. 1998; 58(7): 1408-16[PubMed]
  • 12. Manohar SM, Padgaonkar AA, Jalota-Badhwar A, Sonawane V, Rathos MJ, Kumar S, et al. A novel inhibitor of hypoxia-inducible factor-1alpha P3155 also modulates PI3K pathway and inhibits growth of prostate cancer cells. BMC Cancer. 2011; 11: 338[DOI][PubMed]
  • 13. Ryu YK, Lee JW, Moon EY. Thymosin Beta-4, Actin-Sequestering Protein Regulates Vascular Endothelial Growth Factor Expression via Hypoxia-Inducible Nitric Oxide Production in HeLa Cervical Cancer Cells. Biomol Ther (Seoul). 2015; 23(1): 19-25[DOI][PubMed]
  • 14. Miyazaki K, Kawamoto T, Tanimoto K, Nishiyama M, Honda H, Kato Y. Identification of functional hypoxia response elements in the promoter region of the DEC1 and DEC2 genes. J Biol Chem. 2002; 277(49): 47014-21[DOI][PubMed]
  • 15. Coulet F, Nadaud S, Agrapart M, Soubrier F. Identification of hypoxia-response element in the human endothelial nitric-oxide synthase gene promoter. J Biol Chem. 2003; 278(47): 46230-40[DOI][PubMed]
  • 16. Park J, Park SY, Shin E, Lee SH, Kim YS, Lee DH, et al. Hypoxia inducible factor-1alpha directly regulates nuclear clusterin transcription by interacting with hypoxia response elements in the clusterin promoter. Mol Cells. 2014; 37(2): 178-86[DOI][PubMed]
  • 17. Fink T, Kazlauskas A, Poellinger L, Ebbesen P, Zachar V. Identification of a tightly regulated hypoxia-response element in the promoter of human plasminogen activator inhibitor-1. Blood. 2002; 99(6): 2077-83[PubMed]
  • 18. Ingram N, Porter CD. Transcriptional targeting of acute hypoxia in the tumour stroma is a novel and viable strategy for cancer gene therapy. Gene Ther. 2005; 12(13): 1058-69[DOI][PubMed]
  • 19. Collet G, Lamerant-Fayel N, Tertil M, El Hafny-Rahbi B, Stepniewski J, Guichard A, et al. Hypoxia-regulated overexpression of soluble VEGFR2 controls angiogenesis and inhibits tumor growth. Mol Cancer Ther. 2014; 13(1): 165-78[DOI][PubMed]
  • 20. Gao H, Huang Z, Shi C, Li H. Construction and detection of the tissue-specific pINV-HPV16 E6/7 vector. Oncol Lett. 2015; 9(2): 857-62[DOI][PubMed]
  • 21. Runtuwene J, Amitani H, Amitani M, Asakawa A, Cheng KC, Inui A. Hydrogen-water enhances 5-fluorouracil-induced inhibition of colon cancer. PeerJ. 2015; 3: 859[DOI][PubMed]
  • 22. Chang CC, Shieh GS, Wu P, Lin CC, Shiau AL, Wu CL. Oct-3/4 expression reflects tumor progression and regulates motility of bladder cancer cells. Cancer Res. 2008; 68(15): 6281-91[DOI][PubMed]
  • 23. Covello KL, Kehler J, Yu H, Gordan JD, Arsham AM, Hu CJ, et al. HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth. Genes Dev. 2006; 20(5): 557-70[DOI][PubMed]
  • 24. Petrella BL, Lohi J, Brinckerhoff CE. Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2 alpha in von Hippel-Lindau renal cell carcinoma. Oncogene. 2005; 24(6): 1043-52[DOI][PubMed]
  • 25. Wang V, Davis DA, Haque M, Huang LE, Yarchoan R. Differential gene up-regulation by hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha in HEK293T cells. Cancer Res. 2005; 65(8): 3299-306[DOI][PubMed]
  • 26. Rankin EB, Giaccia AJ. The role of hypoxia-inducible factors in tumorigenesis. Cell Death Differ. 2008; 15(4): 678-85[DOI][PubMed]
  • 27. Voss MJ, Moller MF, Powe DG, Niggemann B, Zanker KS, Entschladen F. Luminal and basal-like breast cancer cells show increased migration induced by hypoxia, mediated by an autocrine mechanism. BMC Cancer. 2011; 11: 158[DOI][PubMed]
  • 28. Harada H, Kizaka-Kondoh S, Itasaka S, Shibuya K, Morinibu A, Shinomiya K, et al. The combination of hypoxia-response enhancers and an oxygen-dependent proteolytic motif enables real-time imaging of absolute HIF-1 activity in tumor xenografts. Biochem Biophys Res Commun. 2007; 360(4): 791-6[DOI][PubMed]
  • 29. Fukui N, Kageyama Y, Higashi Y, Kihara K, Kizaka-Kondoh S, Hiraoka M, et al. Development of a novel interferon-alpha2b gene construct with a repetitive hypoxia-inducible factor binding site and its suppressive effects on human renal cell carcinoma cell lines in vitro. Int J Clin Oncol. 2014; 19(3): 497-504[DOI][PubMed]
  • 30. Koshikawa N, Takenaga K, Tagawa M, Sakiyama S. Therapeutic efficacy of the suicide gene driven by the promoter of vascular endothelial growth factor gene against hypoxic tumor cells. Cancer Res. 2000; 60(11): 2936-41[PubMed]
  • 31. Honda T, Kagawa S, Spurgers KB, Gjertsen BT, Roth JA, Fang B. A recombinant adenovirus expressing wild-type Bax induces apoptosis in prostate cancer cells independently of their Bcl-2 status and androgen sensitivity. . Cancer Biol Ther. 2002; 1(2): 163-7
  • 32. Ozawa T, Hu JL, Hu LJ, Kong EL, Bollen AW, Lamborn KR, et al. Functionality of hypoxia-induced BAX expression in a human glioblastoma xenograft model. Cancer Gene Ther. 2005; 12(5): 449-55[DOI][PubMed]
  • 33. Yang L, Cao Z, Li F, Post DE, Van Meir EG, Zhong H, et al. Tumor-specific gene expression using the survivin promoter is further increased by hypoxia. Gene Ther. 2004; 11(15): 1215-23[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiation Alert
via Google Reader

Readers' Comments