International Journal of Cancer Management

Published by: Kowsar

A Literature Survey on Cost-Effectiveness of Proton Beam Therapy in the Management of Breast Cancer Patients

Reza Reiazi 1 , * , Amir Norozi 1 and Maryam Etedadialiabadi 2
Authors Information
1 Health Insurance Research Office, Armed Forces Insurance Organization of Islamic Republic of Iran, Tehran, IR Iran
2 Radiology Department, Milad Hospital, Tehran, IR Iran
Article information
  • Iranian Journal of Cancer Prevention: December 28, 2015, 8 (6); e4373
  • Published Online: December 23, 2015
  • Article Type: Review Article
  • Received: October 20, 2015
  • Accepted: November 4, 2015
  • DOI: 10.17795/ijcp-4373

To Cite: Reiazi R, Norozi A, Etedadialiabadi M. A Literature Survey on Cost-Effectiveness of Proton Beam Therapy in the Management of Breast Cancer Patients, Int J Cancer Manag. 2015 ; 8(6):e4373. doi: 10.17795/ijcp-4373.

Copyright © 2015, Iranian Journal of Cancer Prevention.This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Context
2. Evidence Acquisition
3. Results
4. Conclusions
  • 1. Darby SC, Ewertz M, McGale P, Bennet AM, Blom-Goldman U, Bronnum D, et al. Risk of ischemic heart disease in women after radiotherapy for breast cancer. N Engl J Med. 2013; 368(11): 987-98[DOI][PubMed]
  • 2. Giordano SH, Kuo YF, Freeman JL, Buchholz TA, Hortobagyi GN, Goodwin JS. Risk of cardiac death after adjuvant radiotherapy for breast cancer. J Natl Cancer Inst. 2005; 97(6): 419-24[DOI][PubMed]
  • 3. Chargari C. The issue of radiation-induced cardiovascular toxicity: preclinical highlights and perspectives on preventive strategies. Biomed J. 2013; 36(3): 150-1[DOI][PubMed]
  • 4. MacDonald SM, Jimenez R, Paetzold P, Adams J, Beatty J, DeLaney TF, et al. Proton radiotherapy for chest wall and regional lymphatic radiation; dose comparisons and treatment delivery. Radiat Oncol. 2013; 8: 71[DOI][PubMed]
  • 5. MacDonald SM, Patel SA, Hickey S, Specht M, Isakoff SJ, Gadd M, et al. Proton therapy for breast cancer after mastectomy: early outcomes of a prospective clinical trial. Int J Radiat Oncol Biol Phys. 2013; 86(3): 484-90[DOI][PubMed]
  • 6. Larsson B, Leksell L, Rexed B, Sourander P, Mair W, Andersson B. The high-energy proton beam as a neurosurgical tool. Nature. 1958; 182(4644): 1222-3[PubMed]
  • 7. Levin WP, Kooy H, Loeffler JS, DeLaney TF. Proton beam therapy. Br J Cancer. 2005; 93(8): 849-54[DOI][PubMed]
  • 8. Goitein M, Jermann M. The relative costs of proton and X-ray radiation therapy. Clin Oncol (R Coll Radiol). 2003; 15(1)-50[PubMed]
  • 9. Lievens Y, Pijls-Johannesma M. Health economic controversy and cost-effectiveness of proton therapy. Semin Radiat Oncol. 2013; 23(2): 134-41[DOI][PubMed]
  • 10. Mailhot Vega RB, Kim J, Bussiere M, Hattangadi J, Hollander A, Michalski J, et al. Cost effectiveness of proton therapy compared with photon therapy in the management of pediatric medulloblastoma. Cancer. 2013; 119(24): 4299-307[DOI][PubMed]
  • 11. Peeters A, Grutters JP, Pijls-Johannesma M, Reimoser S, De Ruysscher D, Severens JL, et al. How costly is particle therapy? Cost analysis of external beam radiotherapy with carbon-ions, protons and photons. Radiother Oncol. 2010; 95(1): 45-53[DOI][PubMed]
  • 12. Pijls-Johannesma M, Pommier P, Lievens Y. Cost-effectiveness of particle therapy: current evidence and future needs. Radiother Oncol. 2008; 89(2): 127-34[DOI][PubMed]
  • 13. Epstein K. Is spending on proton beam therapy for cancer going too far, too fast? BMJ. 2012; 344[DOI][PubMed]
  • 14. Taghian AG, Kozak KR, Katz A, Adams J, Lu HM, Powell SN, et al. Accelerated partial breast irradiation using proton beams: Initial dosimetric experience. Int J Radiat Oncol Biol Phys. 2006; 65(5): 1404-10[DOI][PubMed]
  • 15. Lundkvist J, Ekman M, Ericsson SR, Isacsson U, Jonsson B, Glimelius B. Economic evaluation of proton radiation therapy in the treatment of breast cancer. Radiother Oncol. 2005; 75(2): 179-85[DOI][PubMed]
  • 16. Lundkvist J, Ekman M, Ericsson SR, Jonsson B, Glimelius B. Proton therapy of cancer: potential clinical advantages and cost-effectiveness. Acta Oncol. 2005; 44(8): 850-61[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments