International Journal of Cancer Management

Published by: Kowsar

Preventing and Therapeutic Effect of Propolis in Radiotherapy Induced Mucositis of Head and Neck Cancers: A Triple-Blind, Randomized, Placebo-Controlled Trial

Abbas Javadzadeh Bolouri 1 , Atessa Pakfetrat 1 , Arghavan Tonkaboni 2 , * , Seyed Amir Aledavood 3 , Mohsen Fathi Najafi 4 , Zahra Delavarian 5 , Mohammad Taghi Shakeri 6 and Azade Mohtashami 3
Authors Information
1 Department of Oral Medicine, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, IR Iran
2 Department of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences, Tehran, IR Iran
3 Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, IR Iran
4 Department of Veterinary Research and Biotechnology, Razi Vaccine and Serum Research Institute, Mashhad, IR Iran
5 Department of Oral Medicine, Oral and Maxillofacial Diseases Research Center, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, IR Iran
6 Department of Community Med and Public Health, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, IR Iran
Article information
  • Iranian Journal of Cancer Prevention: October 28, 2015, 8 (5); e4019
  • Published Online: October 27, 2015
  • Article Type: Research Article
  • Received: September 7, 2015
  • Accepted: September 22, 2015
  • DOI: 10.17795/ijcp-4019

To Cite: Javadzadeh Bolouri A, Pakfetrat A, Tonkaboni A, Aledavood S A, Fathi Najafi M, et al. Preventing and Therapeutic Effect of Propolis in Radiotherapy Induced Mucositis of Head and Neck Cancers: A Triple-Blind, Randomized, Placebo-Controlled Trial, Int J Cancer Manag. 2015 ; 8(5):e4019. doi: 10.17795/ijcp-4019.

Abstract
Copyright © 2015, Iranian Journal of Cancer Prevention.This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Method
4. Results
5. Discussion
Acknowledgements
Footnotes
References
  • 1. Little JW. Dental management of the medically compromised patient. 1997;
  • 2. Stewart BW, Kleihues P, International Agency for Research on Cancer . World cancer report. 2003;
  • 3. Silveira A, Gonçalves J, Sequeira T, Ribeiro C, Lopes C, Monteiro E, et al. Oncologia de Cabeça e Pescoço: enquadramento epidemiológico e clínico na avaliação da Qualidade de Vida Relacionada com a Saúde. Revista Brasileira de Epidemiologia. 2012; 15(1): 38-48[DOI]
  • 4. Petersen PE. The World Oral Health Report 2003: continuous improvement of oral health in the 21st century--the approach of the WHO Global Oral Health Programme. Community Dent Oral Epidemiol. 2003; 31 Suppl 1: 3-23[PubMed]
  • 5. Scully C, Epstein JB. Oral health care for the cancer patient. Eur J Cancer B Oral Oncol. 1996; 32B(5): 281-92[PubMed]
  • 6. Vissink A, Burlage FR, Spijkervet FKL, Jansma J, Coppes RP. Prevention and Treatment of the Consequences of Head and Neck Radiotherapy. Crit Rev Oral Biol Med. 2003; 14(3): 213-25[DOI]
  • 7. Suemaru K, Cui R, Li B, Watanabe S, Okihara K, Hashimoto K, et al. Topical application of royal jelly has a healing effect for 5-fluorouracil-induced experimental oral mucositis in hamsters. Methods Find Exp Clin Pharmacol. 2008; 30(2): 103-6[DOI][PubMed]
  • 8. Berger AM, Fall-Dickson Jane M. Devita: Principles and practice of oncology. 2005; : 2523-35
  • 9. Burket LW, Greenberg MS, Glick M, Ship JA. Burket's oral medicine. 2008;
  • 10. Vera-Llonch M, Oster G, Hagiwara M, Sonis S. Oral mucositis in patients undergoing radiation treatment for head and neck carcinoma. Cancer. 2006; 106(2): 329-36[DOI][PubMed]
  • 11. Hall EJ, Giaccia AJ. Radiobiology for the Radiologist. 2006;
  • 12. Farrell CL, Bready JV, Rex KL, Chen JN, DiPalma CR, Whitcomb KL, et al. Keratinocyte growth factor protects mice from chemotherapy and radiation-induced gastrointestinal injury and mortality. Cancer Res. 1998; 58(5): 933-9[PubMed]
  • 13. Khalil ML. Biological activity of bee propolis in health and disease. Asian Pac J Cancer Prev. 2006; 7(1): 22-31[PubMed]
  • 14. Kukreja B, Dodwad V. Propolis mouthwash: A new beginning. J Indian Soc Periodontol. 2011; 15(2): 121[DOI]
  • 15. Scheller S, Gazda G, Krol W, Czuba Z, Zajusz A, Gabrys J, et al. The ability of ethanolic extract of propolis (EEP) to protect mice against gamma irradiation. Z Naturforsch C. 1989; 44(11-12): 1049-52[PubMed]
  • 16. Orsolic N, Benkovic V, Horvat-Knezevic A, Kopjar N, Kosalec I, Bakmaz M, et al. Assessment by survival analysis of the radioprotective properties of propolis and its polyphenolic compounds. Biol Pharm Bull. 2007; 30(5): 946-51[PubMed]
  • 17. You WC, Hsieh CC, Huang JT. Effect of Extracts from Indigowood Root (Isatis indigotica Fort.) on Immune Responses in Radiation-Induced Mucositis. J Alternat Complement Med. 2009; 15(7): 771-8[DOI]
  • 18. Lee SH, Kim TH, Kim JY, Park SY, Pyo HR, Shin KH, et al. Evaluation of parotid gland function following intensity modulated radiation therapy for head and neck cancer. Cancer Res Treat. 2006; 38(2): 84-91[DOI][PubMed]
  • 19. Benderli Cihan Y, Deniz K. [Effect of propolis against radiation-induced oral mucositis in rats]. Kulak Burun Bogaz Ihtis Derg. 2011; 21(1): 32-41[PubMed]
  • 20. Ghassemi L, Zabihi E, Mahdavi R, Seyedmajidi M, Akram S, Motallebnejad M. The effect of ethanolic extract of propolis on radiation-induced mucositis in rats. Saudi Med J. 2010; 31(6): 622-6[PubMed]
  • 21. Olaitan PB, Adeleke OE, Ola IO. Honey: a reservoir for microorganisms and an inhibitory agent for microbes. Afr Health Sci. 2007; 7(3): 159-65[DOI][PubMed]
  • 22. Benkovic V, Orsolic N, Knezevic AH, Ramic S, Dikic D, Basic I, et al. Evaluation of the radioprotective effects of propolis and flavonoids in gamma-irradiated mice: the alkaline comet assay study. Biol Pharm Bull. 2008; 31(1): 167-72[PubMed]
  • 23. Benkovic V, Knezevic AH, Dikic D, Lisicic D, Orsolic N, Basic I, et al. Radioprotective effects of quercetin and ethanolic extract of propolis in gamma-irradiated mice. Arh Hig Rada Toksikol. 2009; 60(2): 129-38[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiation Alert
via Google Reader

Readers' Comments