International Journal of Cancer Management

Published by: Kowsar

Outcomes of Neoadjuvant Radiochemotherapy of Locally Advanced Rectal Adenocarcinoma: Results of 8 Year Experience in Iran Cancer Institute

Mahdi Aghili 1 , Farshid Farhan 1 , Mohammad Babaei 2 , Reza Ghalehtaki 3 , * , Maysa Yamrali 4 , Borna Farazmand 4 , Nima Mousavi Darzikolaei 5 , Esmaeil Asadi Khameneh 6 , Mandana Seyyed Soleymani 7 , Mohammadsadegh Fazeli 8 , Amir Keshvari 8 , Mohammadkazem Nouritaromlou 8 and Peiman Haddad 9
Authors Information
1 MD, Associate Professor, Radiation Oncology Research Center (RORC), Cancer Institute, Tehran University of Medical Sciences, Tehran, IR Iran
2 MD, Assistant Professor, Radiation Oncology Research Center (RORC), Cancer Institute, Tehran University of Medical Sciences, Tehran, IR Iran
3 MD, Resident, Radiation Oncology Research Center (RORC), Cancer Institute, Tehran University of Medical Sciences, Tehran, IR Iran
4 MD, Resident, Department of Radiation Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, IR Iran
5 MD, Department of Radiation Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, IR Iran
6 MD, Medical Student, School of Medicine, Tehran University of Medical Sciences, Tehran, IR Iran
7 Radiation Oncology Research Center (RORC), Cancer Institute, Tehran University of Medical Sciences, Tehran, IR Iran
8 MD, Colorectal Research Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, IR Iran
9 MD, Professor, Radiation Oncology Research Center (RORC), Cancer Institute, Tehran University of Medical Sciences, Tehran, IR Iran
Article information
  • International Journal of Cancer Management: December 2017, 10 (12); e12339
  • Published Online: December 31, 2017
  • Article Type: Research Article
  • Received: May 15, 2017
  • Revised: July 18, 2017
  • Accepted: December 16, 2017
  • DOI: 10.5812/ijcm.12339

To Cite: Aghili M, Farhan F, Babaei M, Ghalehtaki R, Yamrali M, et al. Outcomes of Neoadjuvant Radiochemotherapy of Locally Advanced Rectal Adenocarcinoma: Results of 8 Year Experience in Iran Cancer Institute, Int J Cancer Manag. 2017 ;10(12):e12339. doi: 10.5812/ijcm.12339.

Abstract
Copyright © 2017, Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Methods
3. Results
4. Discussion
Acknowledgements
Footnotes
References
  • 1. Jemal A, Center MM, DeSantis C, Ward EM. Global patterns of cancer incidence and mortality rates and trends. Cancer Epidemiol Biomarkers Prev. 2010;19(8):1893-907. doi: 10.1158/1055-9965.EPI-10-0437. [PubMed: 20647400].
  • 2. Esna Ashari F, Sohrabi MR, Abadi AR, Mehrabian AA, Kolahi AA, Yavari P, et al. Colorectal cancer prevalence according to survival data in Iran in 2007. Res Med. 2008;32:221–5.
  • 3. Davis DM, Marcet JE, Frattini JC, Prather AD, Mateka JJ, Nfonsam VN. Is it time to lower the recommended screening age for colorectal cancer?. J Am Coll Surg. 2011;213(3):352-61. doi: 10.1016/j.jamcollsurg.2011.04.033. [PubMed: 21737316].
  • 4. Parkin DM, Pisani P, Ferlay J. Global cancer statistics. CA Cancer J Clin. 1999;49(1):33-64. 1. [PubMed: 10200776].
  • 5. Malekzadeh R, Bishehsari F, Mahdavinia M, Ansari R. Epidemiology and molecular genetics of colorectal cancer in iran: a review. Arch Iran Med. 2009;12(2):161-9. [PubMed: 19249887].
  • 6. Siegel R, Desantis C, Jemal A. Colorectal cancer statistics, 2014. CA Cancer J Clin. 2014;64(2):104-17. doi: 10.3322/caac.21220. [PubMed: 24639052].
  • 7. van Gijn W, Marijnen CA, Nagtegaal ID, Kranenbarg EM, Putter H, Wiggers T, et al. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer: 12-year follow-up of the multicentre, randomised controlled TME trial. Lancet Oncol. 2011;12(6):575-82. doi: 10.1016/S1470-2045(11)70097-3. [PubMed: 21596621].
  • 8. Sauer R, Becker H, Hohenberger W, Rodel C, Wittekind C, Fietkau R, et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med. 2004;351(17):1731-40. doi: 10.1056/NEJMoa040694. [PubMed: 15496622].
  • 9. Safaee A, Fatemi SR, Ashtari S, Vahedi M, Moghimi-Dehkordi B, Zali MR. Four years incidence rate of colorectal cancer in Iran: a survey of national cancer registry data - implications for screening. Asian Pac J Cancer Prev. 2012;13(6):2695-8. [PubMed: 22938443].
  • 10. Azadeh S, Moghimi-Dehkordi B, Fatem SR, Pourhoseingholi MA, Ghiasi S, Zali MR. Colorectal cancer in Iran: an epidemiological study. Asian Pac J Cancer Prev. 2008;9(1):123-6. [PubMed: 18439090].
  • 11. Pahlavan PS, Kanthan R. The epidemiology and clinical findings of colorectal cancer in Iran. J Gastrointestin Liver Dis. 2006;15(1):15-9. [PubMed: 16680227].
  • 12. Ansari R, Mahdavinia M, Sadjadi A, Nouraie M, Kamangar F, Bishehsari F, et al. Incidence and age distribution of colorectal cancer in Iran: results of a population-based cancer registry. Cancer Lett. 2006;240(1):143-7. doi: 10.1016/j.canlet.2005.09.004. [PubMed: 16288832].
  • 13. Abdifard E, Amini S, Bab S, Masroor N, Khachian A, Heidari M. Incidence trends of colorectal cancer in Iran during 2000-2009: A population-based study. Med J Islam Repub Iran. 2016;30:382. [PubMed: 27493926].
  • 14. Hosseini SV, Izadpanah A, Yarmohammadi H. Epidemiological changes in colorectal cancer in Shiraz, Iran: 1980-2000. ANZ J Surg. 2004;74(7):547-9. doi: 10.1111/j.1445-2197.2004.03064.x. [PubMed: 15230787].
  • 15. Gerard JP, Azria D, Gourgou-Bourgade S, Martel-Laffay I, Hennequin C, Etienne PL, et al. Comparison of two neoadjuvant chemoradiotherapy regimens for locally advanced rectal cancer: results of the phase III trial ACCORD 12/0405-Prodige 2. J Clin Oncol. 2010;28(10):1638-44. doi: 10.1200/JCO.2009.25.8376. [PubMed: 20194850].
  • 16. Marechal R, Vos B, Polus M, Delaunoit T, Peeters M, Demetter P, et al. Short course chemotherapy followed by concomitant chemoradiotherapy and surgery in locally advanced rectal cancer: a randomized multicentric phase II study. Ann Oncol. 2012;23(6):1525-30. doi: 10.1093/annonc/mdr473. [PubMed: 22039087].
  • 17. Perez K, Pricolo V, Vrees M, DiPetrillo TA, Oldenberg N, Klipfel A, et al. A phase II study of complete neoadjuvant therapy in rectal cancer (CONTRE), the brown university oncology group. J Clin Oncol. 2013;31(4):335. doi: 10.1200/jco.2013.31.4_suppl.335.
  • 18. Wolthuis AM, Penninckx F, Haustermans K, De Hertogh G, Fieuws S, Van Cutsem E, et al. Impact of interval between neoadjuvant chemoradiotherapy and TME for locally advanced rectal cancer on pathologic response and oncologic outcome. Ann Surg Oncol. 2012;19(9):2833-41. doi: 10.1245/s10434-012-2327-1. [PubMed: 22451236].
  • 19. Rodel C, Liersch T, Becker H, Fietkau R, Hohenberger W, Hothorn T, et al. Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initial results of the German CAO/ARO/AIO-04 randomised phase 3 trial. Lancet Oncol. 2012;13(7):679-87. doi: 10.1016/S1470-2045(12)70187-0. [PubMed: 22627104].
  • 20. Ferrari L, Fichera A. Neoadjuvant chemoradiation therapy and pathological complete response in rectal cancer. Gastroenterol Rep (Oxf). 2015;3(4):277-88. doi: 10.1093/gastro/gov039. [PubMed: 26290512].
  • 21. Kim NK, Baik SH, Seong JS, Kim H, Roh JK, Lee KY, et al. Oncologic outcomes after neoadjuvant chemoradiation followed by curative resection with tumor-specific mesorectal excision for fixed locally advanced rectal cancer: Impact of postirradiated pathologic downstaging on local recurrence and survival. Ann Surg. 2006;244(6):1024-30. doi: 10.1097/01.sla.0000225360.99257.73. [PubMed: 17122629].
  • 22. de Campos-Lobato LF, Stocchi L, da Luz Moreira A, Geisler D, Dietz DW, Lavery IC, et al. Pathologic complete response after neoadjuvant treatment for rectal cancer decreases distant recurrence and could eradicate local recurrence. Ann Surg Oncol. 2011;18(6):1590-8. doi: 10.1245/s10434-010-1506-1. [PubMed: 21207164].
  • 23. Habr Gama A, Perez RO, Proscurshim I, Gama Rodrigues J, Sabbaga J, Nadalin W, et al. Watch and wait strategy for distal rectal cancer after neoadjuvant CRT, a single institution's experience of 15 years in complete tumor regression without surgery. J Am Coll Surg. 2008;207(3):20. doi: 10.1016/j.jamcollsurg.2008.06.026.
  • 24. Moradi A, Khayamzadeh M, Guya M, Mirzaei HR, Salmanian R, Rakhsha A, et al. Survival of colorectal cancer in Iran. Asian Pac J Cancer Prev. 2009;10(4):583-6. [PubMed: 19827873].
  • 25. Ebrahim Hajizadeh MRA, Ghanbari Motlagh A . Comparison of colon and rectum cancer: survival and prognostic factors. Gastroenterol Hepatol Bed Bench. 2010;3:177–86. doi: 10.22037/ghfbb.v3i4.117.
  • 26. Rodel C, Arnold D, Becker H, Fietkau R, Ghadimi M, Graeven U, et al. Induction chemotherapy before chemoradiotherapy and surgery for locally advanced rectal cancer : is it time for a randomized phase III trial?. Strahlenther Onkol. 2010;186(12):658-64. doi: 10.1007/s00066-010-2194-2. [PubMed: 21136027].
  • 27. Boland PM, Fakih M. The emerging role of neoadjuvant chemotherapy for rectal cancer. J Gastrointest Oncol. 2014;5(5):362-73. doi: 10.3978/j.issn.2078-6891.2014.060. [PubMed: 25276409].
  • 28. Fernandez-Martos C, Pericay C, Aparicio J, Salud A, Safont M, Massuti B, et al. Phase II, randomized study of concomitant chemoradiotherapy followed by surgery and adjuvant capecitabine plus oxaliplatin (CAPOX) compared with induction CAPOX followed by concomitant chemoradiotherapy and surgery in magnetic resonance imaging-defined, locally advanced rectal cancer: Grupo cancer de recto 3 study. J Clin Oncol. 2010;28(5):859-65. doi: 10.1200/JCO.2009.25.8541. [PubMed: 20065174].
  • 29. Benson AB. NCCN clinical practice guidelines in oncology (NCCN Guidelines), rectal cancer, version 2. 2016. Washington: NCCN Clin Pract Guidel Oncol; 2016.
  • 30. Garcia-Aguilar J, Smith DD, Avila K, Bergsland EK, Chu P, Krieg RM, et al. Optimal timing of surgery after chemoradiation for advanced rectal cancer: preliminary results of a multicenter, nonrandomized phase II prospective trial. Ann Surg. 2011;254(1):97-102. doi: 10.1097/SLA.0b013e3182196e1f. [PubMed: 21494121].
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiation Alert
via Google Reader

Readers' Comments